Adenomatous polyposis coli protein nucleates actin assembly and synergizes with the formin mDia1. - Wikidata - awgldk - TriplyDB

Adenomatous polyposis coli protein nucleates actin assembly and synergizes with the formin mDia1.

Adenomatous polyposis coli protein nucleates actin assembly and synergizes with the formin mDia1.

http://www.wikidata.org/entity/Q33950254

about

Messing up disorder: how do missense mutations in the tumor suppressor protein APC lead to cancer?Actin nucleators in the nucleus: an emerging theme Targeting and transport: how microtubules control focal adhesion dynamics Formins at a glance Common formin-regulating sequences in Smy1 and Bud14 are required for the control of actin cable assembly in vivo.Automated screening of microtubule growth dynamics identifies MARK2 as a regulator of leading edge microtubules downstream of Rac1 in migrating cells Cytoplasmic dynamics of the general nuclear import machinery in apically growing syncytial cells Microtubules as platforms for assaying actin polymerization in vivo Molecular Basis of Actin Nucleation Factor Cooperativity: CRYSTAL STRUCTURE OF THE SPIR-1 KINASE NON-CATALYTIC C-LOBE DOMAIN (KIND){middle dot}FORMIN-2 FORMIN SPIR INTERACTION MOTIF (FSI) COMPLEX Mechanism of actin filament nucleation by Vibrio VopL and implications for tandem W domain nucleation Structure of the formin-interaction domain of the actin nucleation-promoting factor Bud6 The Bacterial Effector VopL Organizes Actin into Filament-like Structures The F-BAR protein Hof1 tunes formin activity to sculpt actin cables during polarized growth.Ligand-induced activation of a formin-NPF pair leads to collaborative actin nucleation The APC tumor suppressor is required for epithelial cell polarization and three-dimensional morphogenesis Mitogen-activated protein kinase (MAPK/ERK) regulates adenomatous polyposis coli during growth-factor-induced cell extension Glyceraldehyde 3-phosphate dehydrogenase is required for band 3 (anion exchanger 1) membrane residency in the mammalian kidney An mDia1-INF2 formin activation cascade facilitated by IQGAP1 regulates stable microtubules in migrating cells.Actin-capping protein promotes microtubule stability by antagonizing the actin activity of mDia1 Tumorigenic fragments of APC cause dominant defects in directional cell migration in multiple model systems Rocket launcher mechanism of collaborative actin assembly defined by single-molecule imaging.Direct interaction between two actin nucleators is required in Drosophila oogenesis.Profilin connects actin assembly with microtubule dynamics.Dissecting regulatory networks of filopodia formation in a Drosophila growth cone model Cellular control of cortical actin nucleation.The tumor suppressor adenomatous polyposis coli controls the direction in which a cell extrudes from an epithelium E-cadherin and the cytoskeletal network in colorectal cancer development and metastasis.Self-association of the APC tumor suppressor is required for the assembly, stability, and activity of the Wnt signaling destruction complex.APC/β-catenin-rich complexes at membrane protrusions regulate mammary tumor cell migration and mesenchymal morphology New mechanisms and functions of actin nucleation Small molecule inhibitor of formin homology 2 domains (SMIFH2) reveals the roles of the formin family of proteins in spindle assembly and asymmetric division in mouse oocytes Mechanism and cellular function of Bud6 as an actin nucleation-promoting factor.Differential interactions of the formins INF2, mDia1, and mDia2 with microtubules.Molecular architecture of the Spire-actin nucleus and its implication for actin filament assembly Destruction complex function in the Wnt signaling pathway of Drosophila requires multiple interactions between Adenomatous polyposis coli 2 and Armadillo Structure of a Bud6/Actin Complex Reveals a Novel WH2-like Actin Monomer Recruitment Motif APC binds the Miro/Milton motor complex to stimulate transport of mitochondria to the plasma membrane APC binds intermediate filaments and is required for their reorganization during cell migration.Drosophila homologues of adenomatous polyposis coli (APC) and the formin diaphanous collaborate by a conserved mechanism to stimulate actin filament assembly.The WH2 Domain and Actin Nucleation: Necessary but Insufficient

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P2860

Adenomatous polyposis coli protein nucleates actin assembly and synergizes with the formin mDia1.

http://www.wikidata.org/entity/Q33950254

description

2010 nî lūn-bûn

@nan

2010 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հունիսին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

Adenomatous polyposis coli pro ...... ergizes with the formin mDia1.

@ast

Adenomatous polyposis coli pro ...... ergizes with the formin mDia1.

@en

type

label

Adenomatous polyposis coli pro ...... ergizes with the formin mDia1.

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Adenomatous polyposis coli pro ...... ergizes with the formin mDia1.

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prefLabel

Adenomatous polyposis coli pro ...... ergizes with the formin mDia1.

@ast

Adenomatous polyposis coli pro ...... ergizes with the formin mDia1.

@en

P1433

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P2860

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P1433

Journal of Cell Biology

P1476

Adenomatous polyposis coli pro ...... ergizes with the formin mDia1.

@en

P2093

Bruce L Goode

http://www.w3.org/2001/XMLSchema#string

Francesca Bartolini

http://www.w3.org/2001/XMLSchema#string

Gregg G Gundersen

http://www.w3.org/2001/XMLSchema#string

James B Moseley

http://www.w3.org/2001/XMLSchema#string

Kyoko Okada

http://www.w3.org/2001/XMLSchema#string

Zvonimir Dogic

http://www.w3.org/2001/XMLSchema#string

P2860

Asef, a link between the tumor suppressor APC and G-protein signaling

p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin.

APC binds to the novel protein EB1

p53-cofactor JMY is a multifunctional actin nucleation factor

Lack of adenomatous polyposis coli protein correlates with a decrease in cell migration and overall changes in microtubule stability

A conserved mechanism for Bni1- and mDia1-induced actin assembly and dual regulation of Bni1 by Bud6 and profilin

Coordinated regulation of actin filament turnover by a high-molecular-weight Srv2/CAP complex, cofilin, profilin, and Aip1.

Formin leaky cap allows elongation in the presence of tight capping proteins.

Coronin promotes the rapid assembly and cross-linking of actin filaments and may link the actin and microtubule cytoskeletons in yeast.

Leiomodin is an actin filament nucleator in muscle cells.

P304

1087-1096

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P31

scholarly article

P356

10.1083/JCB.201001016

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P407

P433

7

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P478

189

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P50

Alexandra M Deaconescu

Nikolaus Grigorieff

P577

2010-06-21T00:00:00Z

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44691151

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P698

20566685

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P932

2894447

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