Primary cilia can both mediate and suppress Hedgehog pathway-dependent tumorigenesis. - Wikidata - awgldk - TriplyDB

Primary cilia can both mediate and suppress Hedgehog pathway-dependent tumorigenesis.

Primary cilia can both mediate and suppress Hedgehog pathway-dependent tumorigenesis.

http://www.wikidata.org/entity/Q33954530

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OCRL localizes to the primary cilium: a new role for cilia in Lowe syndrome Autophagy promotes primary ciliogenesis by removing OFD1 from centriolar satellites Disruption of CEP290 microtubule/membrane-binding domains causes retinal degeneration Arsenic trioxide inhibits human cancer cell growth and tumor development in mice by blocking Hedgehog/GLI pathway The cilia-regulated proteasome and its role in the development of ciliopathies and cancer Ciliogenesis and the DNA damage response: a stressful relationship Cilia in autophagy and cancer Current topics of functional links between primary cilia and cell cycle ARPKD and early manifestations of ADPKD: the original polycystic kidney disease and phenocopies Cilia in vertebrate development and disease Crosstalk between Wnt/β-catenin and Hedgehog/Gli signaling pathways in colon cancer and implications for therapy Basal cell carcinoma - molecular biology and potential new therapies Primary cilium and sonic hedgehog signaling during neural tube patterning: role of GPCRs and second messengers Cell cycle progression by the repression of primary cilia formation in proliferating cells Scrutinizing ciliopathies by unraveling ciliary interaction networks The role of the cilium in normal and abnormal cell cycles: emphasis on renal cystic pathologies Single-molecule imaging of Hedgehog pathway protein Smoothened in primary cilia reveals binding events regulated by Patched1 Novel small molecules targeting ciliary transport of Smoothened and oncogenic Hedgehog pathway activation.Cilium assembly and disassembly IFT-Cargo Interactions and Protein Transport in Cilia Kif3a deficiency reverses the skeletal abnormalities in Pkd1 deficient mice by restoring the balance between osteogenesis and adipogenesis A novel synthetic smoothened antagonist transiently inhibits pancreatic adenocarcinoma xenografts in a mouse model Role of epidermal primary cilia in the homeostasis of skin and hair follicles Arl13b-regulated cilia activities are essential for polarized radial glial scaffold formation Planar cell polarity effector gene Intu regulates cell fate-specific differentiation of keratinocytes through the primary cilia A role for the primary cilium in Notch signaling and epidermal differentiation during skin development Primary cilia control hedgehog signaling during muscle differentiation and are deregulated in rhabdomyosarcoma A Group of ent-Kaurane Diterpenoids Inhibit Hedgehog Signaling and Induce Cilia Elongation Increased hedgehog signaling in postnatal kidney results in aberrant activation of nephron developmental programs Directional cell migration and chemotaxis in wound healing response to PDGF-AA are coordinated by the primary cilium in fibroblasts Functional analysis of limb transcriptional enhancers in the mouse The primary cilium: a signalling centre during vertebrate development The role of canonical and non-canonical Hedgehog signaling in tumor progression in a mouse model of small cell lung cancer.Trafficking to the primary cilium membrane.TLR2 activation inhibits embryonic neural progenitor cell proliferation Heterotrimeric kinesin-II is necessary and sufficient to promote different stepwise assembly of morphologically distinct bipartite cilia in Drosophila antenna.The Nek8 protein kinase, mutated in the human cystic kidney disease nephronophthisis, is both activated and degraded during ciliogenesis.Lineage specificity of primary cilia in the mouse embryo Primary ciliogenesis defects are associated with human astrocytoma/glioblastoma cells.Primary cilia respond to fluid shear stress and mediate flow-induced calcium deposition in osteoblasts.

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P2860

Primary cilia can both mediate and suppress Hedgehog pathway-dependent tumorigenesis.

http://www.wikidata.org/entity/Q33954530

description

2009 nî lūn-bûn

@nan

2009 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2009年の論文

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2009年論文

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2009年論文

@zh-hant

2009年論文

@zh-hk

2009年論文

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2009年論文

@zh-tw

2009年论文

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name

Primary cilia can both mediate and suppress Hedgehog pathway-dependent tumorigenesis.

@ast

Primary cilia can both mediate and suppress Hedgehog pathway-dependent tumorigenesis.

@en

type

label

Primary cilia can both mediate and suppress Hedgehog pathway-dependent tumorigenesis.

@ast

Primary cilia can both mediate and suppress Hedgehog pathway-dependent tumorigenesis.

@en

prefLabel

Primary cilia can both mediate and suppress Hedgehog pathway-dependent tumorigenesis.

@ast

Primary cilia can both mediate and suppress Hedgehog pathway-dependent tumorigenesis.

@en

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P1433

Nature Medicine

P1476

Primary cilia can both mediate and suppress Hedgehog pathway-dependent tumorigenesis.

@en

P2093

Alexandre N Ermilov

http://www.w3.org/2001/XMLSchema#string

Allen D Seol

http://www.w3.org/2001/XMLSchema#string

Andrzej A Dlugosz

http://www.w3.org/2001/XMLSchema#string

Christopher K Bichakjian

http://www.w3.org/2001/XMLSchema#string

Ervin H Epstein

http://www.w3.org/2001/XMLSchema#string

Jeremy F Reiter

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Po-Lin So

http://www.w3.org/2001/XMLSchema#string

Sunny Y Wong

http://www.w3.org/2001/XMLSchema#string

P2860

Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function

Activating Smoothened mutations in sporadic basal-cell carcinoma

Vertebrate Smoothened functions at the primary cilium.

Expression of the GLI2 oncogene and its isoforms in human basal cell carcinoma

Induction of sonic hedgehog mediators by transforming growth factor-beta: Smad3-dependent activation of Gli2 and Gli1 expression in vitro and in vivo

Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours

Missense mutations in SMOH in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system

Cilia and developmental signaling

GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis

Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors

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P304

1055-1061

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scholarly article

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10.1038/NM.2011

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P433

9

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P478

15

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P577

2009-08-23T00:00:00Z

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26761518

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19701205

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2895420

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