Analysis of genomic integrity and p53-dependent G1 checkpoint in telomerase-induced extended-life-span human fibroblasts.
about
Control of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1Human heterochromatin protein 1 isoforms HP1(Hsalpha) and HP1(Hsbeta) interfere with hTERT-telomere interactions and correlate with changes in cell growth and response to ionizing radiationTelomerase expression is sufficient for chromosomal integrity in cells lacking p53 dependent G1 checkpoint function.Strict control of telomerase activation using Cre-mediated inversion.Alternative pathways for the extension of cellular life span: inactivation of p53/pRb and expression of telomerase.The role of senescence and immortalization in carcinogenesis.Altered telomere nuclear matrix interactions and nucleosomal periodicity in ataxia telangiectasia cells before and after ionizing radiation treatmentHeterogeneous nuclear ribonucleoproteins C1 and C2 associate with the RNA component of human telomerase.Biallelic mutations in p16(INK4a) confer resistance to Ras- and Ets-induced senescence in human diploid fibroblastsTelomeres, aging and cancer: in search of a happy ending.Regulation of the human telomerase reverse transcriptase gene.ATM function and telomere stability.Telomere shortening alters the kinetics of the DNA damage response after ionizing radiation in human cells.Resistance to apoptosis, increased growth potential, and altered gene expression in cells that survived genotoxic hexavalent chromium [Cr(VI)] exposure.Invasion of normal human fibroblasts induced by v-Fos is independent of proliferation, immortalization, and the tumor suppressors p16INK4a and p53.Bloom syndrome cells undergo p53-dependent apoptosis and delayed assembly of BRCA1 and NBS1 repair complexes at stalled replication forks.p53 suppression overwhelms DNA polymerase eta deficiency in determining the cellular UV DNA damage responseSpectral karyotyping of human, mouse, rat and ape chromosomes--applications for genetic diagnostics and research.Immortality of cancers: a consequence of inherent karyotypic variations and selections for autonomy.Rs2853677 modulates Snail1 binding to the TERT enhancer and affects lung adenocarcinoma susceptibility.The Oncogenic Potential of Mesenchymal Stem Cells in the Treatment of Cancer: Directions for Future Research.Establishment of proliferative tetraploid cells from telomerase-immortalized normal human fibroblasts.MLH1 mediates PARP-dependent cell death in response to the methylating agent N-methyl-N-nitrosourea.Reconstitution of active telomerase in primary human foreskin fibroblasts: effects on proliferative characteristics and response to ionizing radiation.Poly(ADP-ribose) polymerase-1 is a positive regulator of the p53-mediated G1 arrest response following ionizing radiation.Evidence that high telomerase activity may induce a senescent-like growth arrest in human fibroblasts.Telomerase immortalization of human myometrial cells.Comparison of human mammary epithelial cells immortalized by simian virus 40 T-Antigen or by the telomerase catalytic subunit.Characterization of ataxia telangiectasia fibroblasts with extended life-span through telomerase expression.Extended lifespan of Barrett's esophagus epithelium transduced with the human telomerase catalytic subunit: a useful in vitro model.Telomere-independent cellular senescence in human fetal cardiomyocytes.Formation of functional tissue from transplanted adrenocortical cells expressing telomerase reverse transcriptase.
P2860
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P2860
Analysis of genomic integrity and p53-dependent G1 checkpoint in telomerase-induced extended-life-span human fibroblasts.
description
1999 nî lūn-bûn
@nan
1999 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի մարտին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Analysis of genomic integrity ...... d-life-span human fibroblasts.
@ast
Analysis of genomic integrity ...... d-life-span human fibroblasts.
@en
type
label
Analysis of genomic integrity ...... d-life-span human fibroblasts.
@ast
Analysis of genomic integrity ...... d-life-span human fibroblasts.
@en
prefLabel
Analysis of genomic integrity ...... d-life-span human fibroblasts.
@ast
Analysis of genomic integrity ...... d-life-span human fibroblasts.
@en
P2093
P2860
P356
P1476
Analysis of genomic integrity ...... d-life-span human fibroblasts.
@en
P2093
J A Squire
S Benchimol
T K Pandita
P2860
P304
P356
10.1128/MCB.19.3.2373
P407
P577
1999-03-01T00:00:00Z