Requirement for the kinase activity of human DNA-dependent protein kinase catalytic subunit in DNA strand break rejoining - Wikidata - awgldk - TriplyDB

Requirement for the kinase activity of human DNA-dependent protein kinase catalytic subunit in DNA strand break rejoining

Requirement for the kinase activity of human DNA-dependent protein kinase catalytic subunit in DNA strand break rejoining

http://www.wikidata.org/entity/Q33958394

about

The role of DNA polymerase activity in human non-homologous end joining Ku recruits XLF to DNA double-strand breaks Synapsis of DNA ends by DNA-dependent protein kinase Ku recruits the XRCC4-ligase IV complex to DNA ends Artemis is a phosphorylation target of ATM and ATR and is involved in the G2/M DNA damage checkpoint response Structural and functional interaction between the human DNA repair proteins DNA ligase IV and XRCC4 Essential role for DNA-PKcs in DNA double-strand break repair and apoptosis in ATM-deficient lymphocytes The leucine rich region of DNA-PKcs contributes to its innate DNA affinity.Terminal DNA structure and ATP influence binding parameters of the DNA-dependent protein kinase at an early step prior to DNA synapsis.Therapeutic Implications for Overcoming Radiation Resistance in Cancer Therapy Beyond DNA repair: DNA-PK function in cancer DNA-PK: a dynamic enzyme in a versatile DSB repair pathway Identification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase.Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks.Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair.The DNA-dependent protein kinase: A multifunctional protein kinase with roles in DNA double strand break repair and mitosis Ubiquitylation, neddylation and the DNA damage response Werner protein is a target of DNA-dependent protein kinase in vivo and in vitro, and its catalytic activities are regulated by phosphorylation Role of non-homologous end joining in V(D)J recombination The HINT1 tumor suppressor regulates both gamma-H2AX and ATM in response to DNA damage Functional intersection of ATM and DNA-dependent protein kinase catalytic subunit in coding end joining during V(D)J recombination Pathways of DNA double-strand break repair during the mammalian cell cycle Autophosphorylation of DNA-PKCS regulates its dynamics at DNA double-strand breaks.Extensive ssDNA end formation at DNA double-strand breaks in non-homologous end-joining deficient cells during the S phase Both V(D)J recombination and radioresistance require DNA-PK kinase activity, though minimal levels suffice for V(D)J recombination.Thymoquinone induces telomere shortening, DNA damage and apoptosis in human glioblastoma cells Inhibition of homologous recombination by variants of the catalytic subunit of the DNA-dependent protein kinase (DNA-PKcs)Non-homologous end joining: emerging themes and unanswered questions.DNA-PKcs is critical for telomere capping DNA-dependent protein kinase suppresses double-strand break-induced and spontaneous homologous recombination.Coincident In Vitro Analysis of DNA-PK-Dependent and -Independent Nonhomologous End Joining.Targeting nonhomologous end-joining through epidermal growth factor receptor inhibition: rationale and strategies for radiosensitization.Enhanced fidelity for rejoining radiation-induced DNA double-strand breaks in the G2 phase of Chinese hamster ovary cells A single amino acid substitution in DNA-PKcs explains the novel phenotype of the CHO mutant, XR-C2.DNA double-strand break repair in Caenorhabditis elegans Telomeres, chromosome instability and cancer A structural model for regulation of NHEJ by DNA-PKcs autophosphorylation Involvement of DNA-dependent protein kinase in normal cell cycle progression through mitosis.Differential role of DNA-PKcs phosphorylations and kinase activity in radiosensitivity and chromosomal instability.Scanning fluorescence correlation spectroscopy techniques to quantify the kinetics of DNA double strand break repair proteins after γ-irradiation and bleomycin treatment.

P2860

Q24291484-1FDC26BB-C8B7-45DF-8CE8-6DF371D3F6D5 Q24302301-8BA4C4F8-675E-4025-8C49-130ACE43E523 Q24536754-E6CD89E7-FF5C-4F4C-8DB2-FB4AD140B823 Q24554252-68952E3F-8182-4E43-BD83-49CA68E8796A Q24561444-9736FDFC-DE21-4048-BB8A-449EADDBA864 Q24644339-FEF53DC6-8D6E-470D-B688-1A41B669BC88 Q24649590-5556E6C9-10CA-41A6-BCE7-5596F0D0B0E2 Q24810597-99F8EFFA-4266-4E84-8942-0F44E4DDDF41 Q25257508-16D545AB-41F7-4BA6-A30F-8A9F7E3CCBC9 Q26777016-C617B4DA-ED1A-4F43-9E29-600C0AD91745 Q26827232-51EAC8FA-BFD9-4EB2-87E5-4FD9EBF39839 Q26866928-48D3C81E-9974-4E27-ABE1-15EA606DA850 Q27919628-4FF123B5-C712-43D9-9731-E92AFB0E5E17 Q27919629-6A71A5EE-831A-4240-AD86-E576C07BB471 Q27919641-1FCC12FF-08EA-48BF-BC9F-6B153948FD27 Q28081821-68EA2129-DC17-4C41-829C-55236489D149 Q28087342-0B69CA81-C54B-487C-A3CC-EC3816BF0EA4 Q28206293-CF99B68E-F6D3-4F6F-B183-48DF85C7D7EC Q28266265-9AAEADEE-554B-4424-ABA9-0867653E869D Q28385968-91F0C2D1-673A-49CA-9B45-FE0DA4F1CC3D Q28508673-AF940DF6-CA4F-4FF7-9082-850CF5844F2D Q28608969-A8680AD3-78FE-4275-A16D-1CBDED7A5E6C Q33282240-62DD1587-8A01-4FE5-961C-5E5678AE9D80 Q33304039-3E98ABCF-658F-40C1-9564-D7E5E0497F4B Q33616301-A6C091CD-01F9-469A-BACD-EAC1EC48264B Q33658587-72D8A4B9-3154-4E85-B81D-A4EE300170AF Q33818265-11BED33D-CBC4-44AA-9053-8593F4B34A27 Q33854272-ECD67DDC-185E-4C6C-86BC-3AD4420A9741 Q33952920-F0C858D8-629F-4113-8020-8F87AF120667 Q34020119-6ADA2B11-70AC-4E61-8DF8-A223D9322E04 Q34058485-D47A2BCF-6070-4363-BD01-FF976AC9ED1C Q34138796-EF559ABC-FA9A-4655-8864-EB82050C745B Q34333329-570F4F6B-4A95-41C4-BBDE-80BB206D0204 Q34396025-175BD68F-A0FF-4BF9-AB83-5B248C73B8B3 Q34525913-D2312D45-D49E-4221-A05D-C82B8E275F28 Q34595437-428580BC-0BE8-44AA-97AD-80EC789D9A13 Q34610477-210CB64D-DE08-48CF-B195-9237147A88F3 Q34752724-61D1464D-E02F-4A2E-BBBC-E17384363659 Q34775122-CC7CC75C-8996-440B-8B4A-8DAA6AD0E14E Q35020201-0E70833E-06BC-4547-8628-F71CD5C4789B

P2860

Requirement for the kinase activity of human DNA-dependent protein kinase catalytic subunit in DNA strand break rejoining

http://www.wikidata.org/entity/Q33958394

description

1999 nî lūn-bûn

@nan

1999 թուականի Մայիսին հրատարակուած գիտական յօդուած

@hyw

1999 թվականի մայիսին հրատարակված գիտական հոդված

@hy

1999年の論文

@ja

1999年論文

@yue

1999年論文

@zh-hant

1999年論文

@zh-hk

1999年論文

@zh-mo

1999年論文

@zh-tw

1999年论文

@wuu

name

Requirement for the kinase act ...... in DNA strand break rejoining

@ast

Requirement for the kinase act ...... in DNA strand break rejoining

@en

type

label

Requirement for the kinase act ...... in DNA strand break rejoining

@ast

Requirement for the kinase act ...... in DNA strand break rejoining

@en

prefLabel

Requirement for the kinase act ...... in DNA strand break rejoining

@ast

Requirement for the kinase act ...... in DNA strand break rejoining

@en

P1433

Q33958394-736446B0-FE36-4B26-944C-AB1C06578E4E

P1476

Q33958394-381250C8-87F3-460D-8A85-95DD5820BE0F

P2093

Q33958394-3E32FEAF-0C96-47FC-81D1-AA8C24C205B5

Q33958394-5D3930CC-BA0A-4921-9E72-4D06275905B0

Q33958394-697E4E92-54DC-4358-8C5E-7A4126AF9E8A

Q33958394-8527FF4F-4EA4-44F8-93D6-BEB030780E7C

Q33958394-9EC64581-69EB-439E-AAEF-8905B10EA0CB

Q33958394-C5401EE7-BB50-4D87-A648-3A09CAF6DB68

Q33958394-F5B35BC1-9C4A-4AF2-B261-3443E29B1C85

P2860

Q33958394-0001C91C-B6F0-4552-B81B-CED275830AC9

Q33958394-0A407416-959F-4411-81D7-D02F2C3FC253

Q33958394-0CF0F120-F610-43CB-9267-B70593C1A4EC

Q33958394-0DCDB8E2-7947-40AC-8D8E-6C4A37FF9742

Q33958394-13795217-A327-4368-BC06-270DC8754901

Q33958394-158B1EFB-7654-4814-83EA-CFD94A5483CB

Q33958394-17F496DD-0C04-4B65-B410-BE0CB49F3488

Q33958394-1DEFA0C6-4F67-46D4-BB50-49861929B6F0

Q33958394-22A81E3E-A831-4635-83A3-51FC7012D106

Q33958394-2B333E6B-C42A-41D2-AD4A-B08BCFFA1281

P304

Q33958394-018DB59C-BF35-4507-A87C-6DB871184BF1

P31

Q33958394-DFF6AD2E-677C-4BB9-84D7-20B9292379C7

P356

Q33958394-DD9B2C5D-D95E-4A50-8212-9C99991D6611

P407

Q33958394-B64E8CB0-0DCF-46F5-A0D7-142115611854

P433

Q33958394-19D818C4-D814-4B65-8535-54F853576575

P478

Q33958394-EBE335D9-47A0-4177-A90E-4AED077D1268

P577

Q33958394-FB352676-E3E5-48B5-A13F-2FD45230DE27

P698

Q33958394-F5B1B9EF-E9ED-40C7-A7DE-B12FAC7F0F8E

P932

Q33958394-56568F77-9AF4-447D-A669-88F15ADB9F20

P356

P1433

Molecular and Cellular Biology

P1476

Requirement for the kinase act ...... in DNA strand break rejoining

@en

P2093

A Kurimasa

http://www.w3.org/2001/XMLSchema#string

C S Tung

http://www.w3.org/2001/XMLSchema#string

D J Chen

http://www.w3.org/2001/XMLSchema#string

M D Story

http://www.w3.org/2001/XMLSchema#string

N V Boubnov

http://www.w3.org/2001/XMLSchema#string

S Kumano

http://www.w3.org/2001/XMLSchema#string

S R Peterson

http://www.w3.org/2001/XMLSchema#string

P2860

A single ataxia telangiectasia gene with a product similar to PI-3 kinase

DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product

A DNA-activated protein kinase from HeLa cell nuclei

Phosphotransferase and substrate binding mechanism of the cAMP-dependent protein kinase catalytic subunit from porcine heart as deduced from the 2.0 A structure of the complex with Mn2+ adenylyl imidodiphosphate and inhibitor peptide PKI(5-24)

PIK-related kinases: DNA repair, recombination, and cell cycle checkpoints.

Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair.

Cloning of cDNAs for Fanconi's anaemia by functional complementation

Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification

Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination

Binding of Ku and c-Abl at the kinase homology region of DNA-dependent protein kinase catalytic subunit

P304

3877-3884

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1128/MCB.19.5.3877

http://www.w3.org/2001/XMLSchema#string

P407

P433

5

http://www.w3.org/2001/XMLSchema#string

P478

19

http://www.w3.org/2001/XMLSchema#string

P577

1999-05-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

10207111

http://www.w3.org/2001/XMLSchema#string

P932

84245

http://www.w3.org/2001/XMLSchema#string