Requirement for the kinase activity of human DNA-dependent protein kinase catalytic subunit in DNA strand break rejoining
about
The role of DNA polymerase activity in human non-homologous end joiningKu recruits XLF to DNA double-strand breaksSynapsis of DNA ends by DNA-dependent protein kinaseKu recruits the XRCC4-ligase IV complex to DNA endsArtemis is a phosphorylation target of ATM and ATR and is involved in the G2/M DNA damage checkpoint responseStructural and functional interaction between the human DNA repair proteins DNA ligase IV and XRCC4Essential role for DNA-PKcs in DNA double-strand break repair and apoptosis in ATM-deficient lymphocytesThe leucine rich region of DNA-PKcs contributes to its innate DNA affinity.Terminal DNA structure and ATP influence binding parameters of the DNA-dependent protein kinase at an early step prior to DNA synapsis.Therapeutic Implications for Overcoming Radiation Resistance in Cancer TherapyBeyond DNA repair: DNA-PK function in cancerDNA-PK: a dynamic enzyme in a versatile DSB repair pathwayIdentification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase.Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks.Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair.The DNA-dependent protein kinase: A multifunctional protein kinase with roles in DNA double strand break repair and mitosisUbiquitylation, neddylation and the DNA damage responseWerner protein is a target of DNA-dependent protein kinase in vivo and in vitro, and its catalytic activities are regulated by phosphorylationRole of non-homologous end joining in V(D)J recombinationThe HINT1 tumor suppressor regulates both gamma-H2AX and ATM in response to DNA damageFunctional intersection of ATM and DNA-dependent protein kinase catalytic subunit in coding end joining during V(D)J recombinationPathways of DNA double-strand break repair during the mammalian cell cycleAutophosphorylation of DNA-PKCS regulates its dynamics at DNA double-strand breaks.Extensive ssDNA end formation at DNA double-strand breaks in non-homologous end-joining deficient cells during the S phaseBoth V(D)J recombination and radioresistance require DNA-PK kinase activity, though minimal levels suffice for V(D)J recombination.Thymoquinone induces telomere shortening, DNA damage and apoptosis in human glioblastoma cellsInhibition of homologous recombination by variants of the catalytic subunit of the DNA-dependent protein kinase (DNA-PKcs)Non-homologous end joining: emerging themes and unanswered questions.DNA-PKcs is critical for telomere cappingDNA-dependent protein kinase suppresses double-strand break-induced and spontaneous homologous recombination.Coincident In Vitro Analysis of DNA-PK-Dependent and -Independent Nonhomologous End Joining.Targeting nonhomologous end-joining through epidermal growth factor receptor inhibition: rationale and strategies for radiosensitization.Enhanced fidelity for rejoining radiation-induced DNA double-strand breaks in the G2 phase of Chinese hamster ovary cellsA single amino acid substitution in DNA-PKcs explains the novel phenotype of the CHO mutant, XR-C2.DNA double-strand break repair in Caenorhabditis elegansTelomeres, chromosome instability and cancerA structural model for regulation of NHEJ by DNA-PKcs autophosphorylationInvolvement of DNA-dependent protein kinase in normal cell cycle progression through mitosis.Differential role of DNA-PKcs phosphorylations and kinase activity in radiosensitivity and chromosomal instability.Scanning fluorescence correlation spectroscopy techniques to quantify the kinetics of DNA double strand break repair proteins after γ-irradiation and bleomycin treatment.
P2860
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P2860
Requirement for the kinase activity of human DNA-dependent protein kinase catalytic subunit in DNA strand break rejoining
description
1999 nî lūn-bûn
@nan
1999 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Requirement for the kinase act ...... in DNA strand break rejoining
@ast
Requirement for the kinase act ...... in DNA strand break rejoining
@en
type
label
Requirement for the kinase act ...... in DNA strand break rejoining
@ast
Requirement for the kinase act ...... in DNA strand break rejoining
@en
prefLabel
Requirement for the kinase act ...... in DNA strand break rejoining
@ast
Requirement for the kinase act ...... in DNA strand break rejoining
@en
P2093
P2860
P356
P1476
Requirement for the kinase act ...... in DNA strand break rejoining
@en
P2093
A Kurimasa
N V Boubnov
S R Peterson
P2860
P304
P356
10.1128/MCB.19.5.3877
P407
P577
1999-05-01T00:00:00Z