Zerumbone, a Southeast Asian ginger sesquiterpene, markedly suppresses free radical generation, proinflammatory protein production, and cancer cell proliferation accompanied by apoptosis: the alpha,beta-unsaturated carbonyl group is a prerequisite.

Zerumbone, a Southeast Asian ginger sesquiterpene, markedly suppresses free radical generation, proinflammatory protein production, and cancer cell proliferation accompanied by apoptosis: the alpha,beta-unsaturated carbonyl group is a prerequisite.

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http://www.wikidata.org/entity/Q33959185

Q33959185

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Zerumbone induced apoptosis in liver cancer cells via modulation of Bax/Bcl-2 ratio Zingiber zerumbet (L.) Smith: A Review of Its Ethnomedicinal, Chemical, and Pharmacological Uses South Asian Medicinal Compounds as Modulators of Resistance to Chemotherapy and Radiotherapy Calpain and reactive oxygen species targets Bax for mitochondrial permeabilisation and caspase activation in zerumbone induced apoptosis.Non-specific protein modifications by a phytochemical induce heat shock response for self-defense In vitro ultramorphological assessment of apoptosis induced by zerumbone on (HeLa).Curcumol induces apoptosis via caspases-independent mitochondrial pathway in human lung adenocarcinoma ASTC-a-1 cells.Intracellular and extracellular factors influencing the genotoxicity of nitric oxide and reactive oxygen species.Biomedical properties of a natural dietary plant metabolite, zerumbone, in cancer therapy and chemoprevention trials.Notch2 activation is protective against anticancer effects of zerumbone in human breast cancer cells Zingiber zerumbet CYP71BA1 catalyzes the conversion of α-humulene to 8-hydroxy-α-humulene in zerumbone biosynthesis.A short-chain dehydrogenase involved in terpene metabolism from Zingiber zerumbet.Acute toxicity study of zerumbone-loaded nanostructured lipid carrier on BALB/c mice model Effects of selected food phytochemicals in reducing the toxic actions of TCDD and p,p'-DDT in U937 macrophages Dietary zerumbone prevents against ultraviolet B-induced cataractogenesis in the mouse.The AOM/DSS murine model for the study of colon carcinogenesis: From pathways to diagnosis and therapy studies Dietary zerumbone prevents mouse cornea from UVB-induced photokeratitis through inhibition of NF-κB, iNOS, and TNF-α expression and reduction of MDA accumulation.A 3-hydroxy β-end group in xanthophylls is preferentially oxidized to a 3-oxo ε-end group in mammals.(3E,5E)-3,5-Dibenzyl-idene-1-[3-(piperidin-1-yl)propano-yl]piperidin-4-one.Zerumbone increases oxidative stress in a thiol-dependent ROS-independent manner to increase DNA damage and sensitize colorectal cancer cells to radiation.Binding mode analysis of zerumbone to key signal proteins in the tumor necrosis factor pathway.Zerumbone induces mitochondria-mediated apoptosis via increased calcium, generation of reactive oxygen species and upregulation of soluble histone H2AX in K562 chronic myelogenous leukemia cells.(3E,5E)-3,5-Bis(naphthalen-1-yl-methyl-idene)piperidin-4-one.Inhibitory Effect of Curcumol on Jak2-STAT Signal Pathway Molecules of Fibroblast-Like Synoviocytes in Patients with Rheumatoid Arthritis Possible Contribution of Zerumbone-Induced Proteo-Stress to Its Anti-Inflammatory Functions via the Activation of Heat Shock Factor 1.Chemotherapeutic effect of Zerumbone on melanoma cells through mitochondria-mediated pathways.Expression of cyclooxygenase-2 and clinicopathologic features in human gastric adenocarcinoma.Chemopreventive herbal anti-oxidants: current status and future perspectives Zerumbone causes Bax- and Bak-mediated apoptosis in human breast cancer cells and inhibits orthotopic xenograft growth in vivo.From traditional Ayurvedic medicine to modern medicine: identification of therapeutic targets for suppression of inflammation and cancer.Cancer-preventive anti-oxidants that attenuate free radical generation by inflammatory cells.Herbal Formulation C168 Attenuates Proliferation and Induces Apoptosis in HCT 116 Human Colorectal Carcinoma Cells: Role of Oxidative Stress and DNA Damage.Chemical and biological mechanisms of phytochemical activation of Nrf2 and importance in disease prevention Zerumbone suppresses the motility and tumorigenecity of triple negative breast cancer cells via the inhibition of TGF-β1 signaling pathway Antitumour Effects of Isocurcumenol Isolated from Curcuma zedoaria Rhizomes on Human and Murine Cancer Cells.Zerumbone, a Phytochemical of Subtropical Ginger, Protects against Hyperglycemia-Induced Retinal Damage in Experimental Diabetic Rats Identification of Michael acceptor-centric pharmacophores with substituents that yield strong thioredoxin reductase inhibitory character correlated to antiproliferative activity.Zerumbone, a tropical ginger sesquiterpene, ameliorates streptozotocin-induced diabetic nephropathy in rats by reducing the hyperglycemia-induced inflammatory response Zerumbone enhances TRAIL-induced apoptosis through the induction of death receptors in human colon cancer cells: Evidence for an essential role of reactive oxygen species.Optimization of microwave-assisted extraction of zerumbone from Zingiber zerumbet L. rhizome and evaluation of antiproliferative activity of optimized extracts.

P2860

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P2860

Zerumbone, a Southeast Asian ginger sesquiterpene, markedly suppresses free radical generation, proinflammatory protein production, and cancer cell proliferation accompanied by apoptosis: the alpha,beta-unsaturated carbonyl group is a prerequisite.

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http://www.wikidata.org/entity/Q33959185

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2002 nî lūn-bûn

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2002 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2002年の論文

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