High-throughput kinase profiling: a more efficient approach toward the discovery of new kinase inhibitors.
about
Synthetic biology for pharmaceutical drug discoveryDiscovery of Type II Inhibitors of TGFβ-Activated Kinase 1 (TAK1) and Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2)Development of novel ACK1/TNK2 inhibitors using a fragment-based approachThe PIM kinases in hematological cancersPIM1 kinase as a target for cancer therapyACK1 tyrosine kinase: targeted inhibition to block cancer cell proliferationApplying ligands profiling using multiple extended electron distribution based field templates and feature trees similarity searching in the discovery of new generation of urea-based antineoplastic kinase inhibitorsCOTI-2, a novel small molecule that is active against multiple human cancer cell lines in vitro and in vivo.How chemoproteomics can enable drug discovery and developmentDevelopment of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors.Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.Identification and Characterization of Tyrosine Kinase Nonreceptor 2 Mutations in Leukemia through Integration of Kinase Inhibitor Screening and Genomic AnalysisActivation of HIPK2 Promotes ER Stress-Mediated Neurodegeneration in Amyotrophic Lateral Sclerosis.A guide to picking the most selective kinase inhibitor tool compounds for pharmacological validation of drug targets.The challenge to bring personalized cancer medicine from clinical trials into routine clinical practice: the case of the Institut Gustave Roussy.System-based drug discovery within the human kinome.Computational methods for analysis and inference of kinase/inhibitor relationships.Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinasesStudies of TAK1-centered polypharmacology with novel covalent TAK1 inhibitors.Development of Selective Covalent Janus Kinase 3 Inhibitors.Non-kinase targets of protein kinase inhibitors.A genome-wide RNA interference screen identifies new regulators of androgen receptor function in prostate cancer cellsUnprecedently Large-Scale Kinase Inhibitor Set Enabling the Accurate Prediction of Compound-Kinase Activities: A Way toward Selective Promiscuity by Design?Dclk1 Defines Quiescent Pancreatic Progenitors that Promote Injury-Induced Regeneration and Tumorigenesis.Photonic crystal kinase biosensor.Kinobead and Single-Shot LC-MS Profiling Identifies Selective PKD Inhibitors.Structure-guided development of covalent TAK1 inhibitors.Monitoring and inhibition of Plk1: amphiphilic porphyrin conjugated Plk1 specific peptides for its imaging and anti-tumor function.HIPK2-Mediated Transcriptional Control of NMDA Receptor Subunit Expression Regulates Neuronal Survival and Cell Death
P2860
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P2860
High-throughput kinase profiling: a more efficient approach toward the discovery of new kinase inhibitors.
description
2011 nî lūn-bûn
@nan
2011 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
High-throughput kinase profili ...... very of new kinase inhibitors.
@ast
High-throughput kinase profili ...... very of new kinase inhibitors.
@en
type
label
High-throughput kinase profili ...... very of new kinase inhibitors.
@ast
High-throughput kinase profili ...... very of new kinase inhibitors.
@en
prefLabel
High-throughput kinase profili ...... very of new kinase inhibitors.
@ast
High-throughput kinase profili ...... very of new kinase inhibitors.
@en
P2093
P2860
P50
P1476
High-throughput kinase profili ...... very of new kinase inhibitors.
@en
P2093
Chandrasekhar V Miduturu
Jiing-Dwan Lee
Juerg Schwaller
Laurent Brault
Nathanael S Gray
Nicholas Kwiatkowski
Patrick Zarrinkar
Sanna Herrgard
Wannian Yang
Xianming Deng
P2860
P304
P356
10.1016/J.CHEMBIOL.2011.05.010
P577
2011-07-01T00:00:00Z