Characterization of new mutations in pyrazinamide-resistant strains of Mycobacterium tuberculosis and identification of conserved regions important for the catalytic activity of the pyrazinamidase PncA - Wikidata - awgldk - TriplyDB

Characterization of new mutations in pyrazinamide-resistant strains of Mycobacterium tuberculosis and identification of conserved regions important for the catalytic activity of the pyrazinamidase PncA

Characterization of new mutations in pyrazinamide-resistant strains of Mycobacterium tuberculosis and identification of conserved regions important for the catalytic activity of the pyrazinamidase PncA

http://www.wikidata.org/entity/Q33977235

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Evolution of drug resistance in Mycobacterium tuberculosis: clinical and molecular perspective A balancing act: efflux/influx in mycobacterial drug resistance pncA mutations in clinical Mycobacterium tuberculosis isolates from Korea Systematic review of mutations in pyrazinamidase associated with pyrazinamide resistance in Mycobacterium tuberculosis clinical isolates A Global Perspective on Pyrazinamide Resistance: Systematic Review and Meta-Analysis Specificity and Mechanism ofAcinetobacter baumaniiNicotinamidase: Implications for Activation of the Front-Line Tuberculosis Drug Pyrazinamide Crystal Structure of the Pyrazinamidase of Mycobacterium tuberculosis: Insights into Natural and Acquired Resistance to Pyrazinamide pncA mutations as a major mechanism of pyrazinamide resistance in Mycobacterium tuberculosis: spread of a monoresistant strain in Quebec, Canada Study of the structure-activity relationships for the pyrazinamidase (PncA) from Mycobacterium tuberculosis Base-calling algorithm with vocabulary (BCV) method for analyzing population sequencing chromatograms Mechanisms of Pyrazinamide Action and Resistance Systematic analysis of pyrazinamide-resistant spontaneous mutants and clinical isolates of Mycobacterium tuberculosis.Surveillance of pyrazinamide susceptibility among multidrug-resistant Mycobacterium tuberculosis isolates from Siriraj Hospital, Thailand.Peruvian and globally reported amino acid substitutions on the Mycobacterium tuberculosis pyrazinamidase suggest a conserved pattern of mutations associated to pyrazinamide resistance.Pyrazinamide resistance-conferring mutations in pncA and the transmission of multidrug resistant TB in Georgia Phenotypic characterization of pncA mutants of Mycobacterium tuberculosis.Characteristics of pncA mutations in multidrug-resistant tuberculosis in Taiwan.Molecular epidemiological study of pyrazinamide-resistance in clinical isolates of mycobacterium tuberculosis from South India.Pyrazinamide resistance and pncA gene mutations in Mycobacterium tuberculosis Tuberculosis chemotherapy: the influence of bacillary stress and damage response pathways on drug efficacy.pncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis isolates in Portugal.Structure-Activity relationship in mutated pyrazinamidases from Mycobacterium tuberculosis.Widespread pyrazinamide-resistant Mycobacterium tuberculosis family in a low-incidence setting.Mechanistic analysis elucidating the relationship between Lys96 mutation in Mycobacterium tuberculosis pyrazinamidase enzyme and pyrazinamide susceptibility.Pyrazinoic acid efflux rate in Mycobacterium tuberculosis is a better proxy of pyrazinamide resistance.Role of metal ions on the activity of Mycobacterium tuberculosis pyrazinamidase.Temperature-mediated heteroduplex analysis for detection of pncA mutations associated with pyrazinamide resistance and differentiation between Mycobacterium tuberculosis and Mycobacterium bovis by denaturing high- performance liquid chromatography Modes and modulations of antibiotic resistance gene expression.Correlation between pyrazinamide activity and pncA mutations in Mycobacterium tuberculosis isolates in Taiwan.Effect of pyrazinamidase activity on pyrazinamide resistance in Mycobacterium tuberculosis Pyrazinamide susceptibility testing in Mycobacterium tuberculosis: a systematic review with meta-analyses.Enhanced expression of the multidrug efflux pumps AcrAB and AcrEF associated with insertion element transposition in Escherichia coli mutants Selected with a fluoroquinolone.Mycobacterium smegmatis has two pyrazinamidase enzymes, PncA and pzaA.Characterization of multi-drug resistant Mycobacterium tuberculosis from immigrants residing in the USA using Ion Torrent full-gene sequencing.Characterization of pncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis in Brazil.A comprehensive characterization of PncA polymorphisms that confer resistance to pyrazinamide.Detection by denaturing gradient gel electrophoresis of pncA mutations associated with pyrazinamide resistance in Mycobacterium tuberculosis isolates from the United States-Mexico border region Insight to pyrazinamide resistance in Mycobacterium tuberculosis by molecular docking.Spectrum of pncA mutations in multidrug-resistant Mycobacterium tuberculosis isolates obtained in Latvia.Kinetics and inhibition of nicotinamidase from Mycobacterium tuberculosis.

P2860

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P2860

Characterization of new mutations in pyrazinamide-resistant strains of Mycobacterium tuberculosis and identification of conserved regions important for the catalytic activity of the pyrazinamidase PncA

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P2860

Crystal structure analysis, refinement and enzymatic reaction mechanism of N-carbamoylsarcosine amidohydrolase from Arthrobacter sp. at 2.0 A resolution

Mutations in pncA, a gene encoding pyrazinamidase/nicotinamidase, cause resistance to the antituberculous drug pyrazinamide in tubercle bacillus

Molecular genetic basis of antimicrobial agent resistance in Mycobacterium tuberculosis: 1998 update

Characterization of pncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis

Insertion element IS987 from Mycobacterium bovis BCG is located in a hot-spot integration region for insertion elements in Mycobacterium tuberculosis complex strains.

Mutations associated with pyrazinamide resistance in pncA of Mycobacterium tuberculosis complex organisms

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