Genes for production of the enediyne antitumor antibiotic C-1027 in Streptomyces globisporus are clustered with the cagA gene that encodes the C-1027 apoprotein.
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Polyketide synthase chemistry does not direct biosynthetic divergence between 9- and 10-membered enediynesBiosynthesis of the enediyne antitumor antibiotic C-1027 involves a new branching point in chorismate metabolismCrystal Structure of the Acyltransferase Domain of the Iterative Polyketide Synthase in Enediyne BiosynthesisAntineoplastic agents from natural sources: achievements and future directions.Characterization of the saframycin A gene cluster from Streptomyces lavendulae NRRL 11002 revealing a nonribosomal peptide synthetase system for assembling the unusual tetrapeptidyl skeleton in an iterative manner.Characterization of the tautomycin biosynthetic gene cluster from Streptomyces spiroverticillatus unveiling new insights into dialkylmaleic anhydride and polyketide biosynthesis.Role of sgcR3 in positive regulation of enediyne antibiotic C-1027 production of Streptomyces globisporus C-1027Screening for genes coding for putative antitumor compounds, antimicrobial and enzymatic activities from haloalkalitolerant and haloalkaliphilic bacteria strains of Algerian Sahara SoilsImprovement of the enediyne antitumor antibiotic C-1027 production by manipulating its biosynthetic pathway regulation in Streptomyces globisporusFunctional characterization of TtnD and TtnF, unveiling new insights into tautomycetin biosynthesis.The radiomimetic enediyne, 20'-deschloro-C-1027 induces inter-strand DNA crosslinks in hypoxic cells and overcomes cytotoxic radioresistanceManipulation of pathway regulation in Streptomyces globisporus for overproduction of the enediyne antitumor antibiotic C-1027.Toward improvement of erythromycin A production in an industrial Saccharopolyspora erythraea strain via facilitation of genetic manipulation with an artificial attB site for specific recombination.Characterization of the tautomycetin biosynthetic gene cluster from Streptomyces griseochromogenes provides new insight into dialkylmaleic anhydride biosynthesis.Identification of the biosynthetic gene cluster and regulatory cascade for the synergistic antibacterial antibiotics griseoviridin and viridogrisein in Streptomyces griseoviridis.Expression of the platencin biosynthetic gene cluster in heterologous hosts yielding new platencin congeners.Pharmacokinetics of C-1027 in mice as determined by TCA-RA method.Medium optimization of Streptomyces sp. 17944 for tirandamycin B production and isolation and structural elucidation of tirandamycins H, I and J.Biosynthesis of enediyne antitumor antibioticsTransferable resistance to aminoglycosides by methylation of G1405 in 16S rRNA and to hydrophilic fluoroquinolones by QepA-mediated efflux in Escherichia coli.Engineered production of cancer targeting peptide (CTP)-containing C-1027 in Streptomyces globisporus and biological evaluationCrystal structure of SgcJ, an NTF2-like superfamily protein involved in biosynthesis of the nine-membered enediyne antitumor antibiotic C-1027Draft genome sequence of Streptomyces globisporus C-1027, which produces an antitumor antibiotic consisting of a nine-membered enediyne with a chromoprotein.The biosynthesis, molecular genetics and enzymology of the polyketide-derived metabolites.Genetic modulation of the overexpression of tailoring genes eryK and eryG leading to the improvement of erythromycin A purity and production in Saccharopolyspora erythraea fermentationCloning and characterization of the tetrocarcin A gene cluster from Micromonospora chalcea NRRL 11289 reveals a highly conserved strategy for tetronate biosynthesis in spirotetronate antibiotics.Characterization of the maduropeptin biosynthetic gene cluster from Actinomadura madurae ATCC 39144 supporting a unifying paradigm for enediyne biosynthesis.Predictable and unpredictable evolution of antibiotic resistance.C-1027, a radiomimetic enediyne anticancer drug, preferentially targets hypoxic cellsCharacterization of the SgcF epoxide hydrolase supporting an (R)-vicinal diol intermediate for enediyne antitumor antibiotic C-1027 biosynthesis.Draft Genome Sequence of an Anicemycin Producer, Streptomyces sp. TP-A0648.Molecular insights on the biosynthesis of antitumour compounds by actinomycetes.Iterative type I polyketide synthases involved in enediyne natural product biosynthesis.Cloning and sequencing of the kedarcidin biosynthetic gene cluster from Streptoalloteichus sp. ATCC 53650 revealing new insights into biosynthesis of the enediyne family of antitumor antibiotics.A novel application of radiomimetic compounds as antibiotic drugs.Identification and localization of the gene cluster encoding biosynthesis of the antitumor macrolactam leinamycin in Streptomyces atroolivaceus S-140.Identification and characterization of the ficellomycin biosynthesis gene cluster from Streptomyces ficellus.Binding of a biosynthetic intermediate to AtrA modulates the production of lidamycin by Streptomyces globisporus.
P2860
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P2860
Genes for production of the enediyne antitumor antibiotic C-1027 in Streptomyces globisporus are clustered with the cagA gene that encodes the C-1027 apoprotein.
description
2000 nî lūn-bûn
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2000 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2000年の論文
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2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
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2000年论文
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name
Genes for production of the en ...... encodes the C-1027 apoprotein.
@ast
Genes for production of the en ...... encodes the C-1027 apoprotein.
@en
type
label
Genes for production of the en ...... encodes the C-1027 apoprotein.
@ast
Genes for production of the en ...... encodes the C-1027 apoprotein.
@en
prefLabel
Genes for production of the en ...... encodes the C-1027 apoprotein.
@ast
Genes for production of the en ...... encodes the C-1027 apoprotein.
@en
P2860
P1476
Genes for production of the en ...... encodes the C-1027 apoprotein.
@en
P2860
P304
P356
10.1128/AAC.44.2.382-392.2000
P407
P577
2000-02-01T00:00:00Z