On the importance of being zwitterionic: enzymatic catalysis of decarboxylation and deprotonation of cationic carbon.
about
Computer aided enzyme design and catalytic conceptsLactate racemase is a nickel-dependent enzyme activated by a widespread maturation systemEnzymatic Catalysis of Proton Transfer and Decarboxylation Reactions.Enzymatic catalysis of proton transfer at carbon: activation of triosephosphate isomerase by phosphite dianion.Wildtype and engineered monomeric triosephosphate isomerase from Trypanosoma brucei: partitioning of reaction intermediates in D2O and activation by phosphite dianion.Role of Lys-12 in catalysis by triosephosphate isomerase: a two-part substrate approach.Rescue of K12G triosephosphate isomerase by ammonium cations: the reaction of an enzyme in pieces.Structural insights into stereochemical inversion by diaminopimelate epimerase: an antibacterial drug target.Substituent effects on electrophilic catalysis by the carbonyl group: anatomy of the rate acceleration for PLP-catalyzed deprotonation of glycine.Kinetic isotope effects of L-Dopa decarboxylase.Enzyme architecture: optimization of transition state stabilization from a cation-phosphodianion pair.Extensive site-directed mutagenesis reveals interconnected functional units in the alkaline phosphatase active site.Orotidine 5'-monophosphate decarboxylase: transition state stabilization from remote protein-phosphodianion interactions.Covalent catalysis by pyridoxal: evaluation of the effect of the cofactor on the carbon acidity of glycineComputation of kinetic isotope effects for enzymatic reactions.Molecular dynamics simulations of the intramolecular proton transfer and carbanion stabilization in the pyridoxal 5'-phosphate dependent enzymes L-dopa decarboxylase and alanine racemase.Glycine enolates: the effect of formation of iminium ions to simple ketones on alpha-amino carbon acidity and a comparison with pyridoxal iminium ions.A substrate in pieces: allosteric activation of glycerol 3-phosphate dehydrogenase (NAD+) by phosphite dianion.Pyridoxal 5'-phosphate: electrophilic catalyst extraordinaire.In vitro immunogenic and immunostimulatory effects of zwitterionized 23-valent pneumococcal polysaccharide vaccine compared with nonzwitterionized vaccine.Mechanistic Imperatives for Deprotonation of Carbon Catalyzed by Triosephosphate Isomerase: Enzyme-Activation by Phosphite Dianion.The PLP cofactor: lessons from studies on model reactions.A paradigm for enzyme-catalyzed proton transfer at carbon: triosephosphate isomerase.Specificity in transition state binding: the Pauling model revisited.Catalysis in Enzymatic Decarboxylations: Comparison of Selected Cofactor-dependent and Cofactor-independent Examples.Enzyme architecture: on the importance of being in a protein cage.Tautomeric transition between wobble A·C DNA base mispair and Watson-Crick-like A·C* mismatch: microstructural mechanism and biological significance.Phosphate binding energy and catalysis by small and large molecules.Structure-Reactivity Effects on Intrinsic Primary Kinetic Isotope Effects for Hydride Transfer Catalyzed by Glycerol-3-phosphate Dehydrogenase.L-methionase: a therapeutic enzyme to treat malignancies.Recyclable nitrate-templated photochemical [2+2] cycloaddition reaction promoted by a tripodal receptor.Substituent Effects on Carbon Acidity in Aqueous Solution and at Enzyme Active Sites.
P2860
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P2860
On the importance of being zwitterionic: enzymatic catalysis of decarboxylation and deprotonation of cationic carbon.
description
2004 nî lūn-bûn
@nan
2004 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
On the importance of being zwi ...... rotonation of cationic carbon.
@ast
On the importance of being zwi ...... rotonation of cationic carbon.
@en
type
label
On the importance of being zwi ...... rotonation of cationic carbon.
@ast
On the importance of being zwi ...... rotonation of cationic carbon.
@en
prefLabel
On the importance of being zwi ...... rotonation of cationic carbon.
@ast
On the importance of being zwi ...... rotonation of cationic carbon.
@en
P1433
P1476
On the importance of being zwi ...... rotonation of cationic carbon.
@en
P2093
Tina L Amyes
P304
P356
10.1016/J.BIOORG.2004.05.002
P577
2004-10-01T00:00:00Z