Adenovirus 12 E4orf6 inhibits ATR activation by promoting TOPBP1 degradation - Wikidata - awgldk - TriplyDB

Adenovirus 12 E4orf6 inhibits ATR activation by promoting TOPBP1 degradation

Adenovirus 12 E4orf6 inhibits ATR activation by promoting TOPBP1 degradation

http://www.wikidata.org/entity/Q33982295

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The structure and regulation of Cullin 2 based E3 ubiquitin ligases and their biological functions Viral Mimicry to Usurp Ubiquitin and SUMO Host Pathways Mechanisms of viral mutation The Adenovirus E4orf4 Protein Provides a Novel Mechanism for Inhibition of the DNA Damage Response Genome-Wide Estimation of the Spontaneous Mutation Rate of Human Adenovirus 5 by High-Fidelity Deep Sequencing Tip60 degradation by adenovirus relieves transcriptional repression of viral transcriptional activator EIA.SPOC1-mediated antiviral host cell response is antagonized early in human adenovirus type 5 infection ATR and ATRIP are recruited to herpes simplex virus type 1 replication compartments even though ATR signaling is disabled.E1B and E4 oncoproteins of adenovirus antagonize the effect of apoptosis inducing factor Efficient herpes simplex virus 1 replication requires cellular ATR pathway proteins Cullin E3 ligases and their rewiring by viral factors Proteomic analysis of ubiquitin-like posttranslational modifications induced by the adenovirus E4-ORF3 protein.Herpes simplex virus type 1 single strand DNA binding protein and helicase/primase complex disable cellular ATR signaling.Adenovirus precursor pVII protein stability is regulated by its propeptide sequence.The ATR signaling pathway is disabled during infection with the parvovirus minute virus of mice.TopBP1 interacts with BLM to maintain genome stability but is dispensable for preventing BLM degradation.TOPBP1 recruits TOP2A to ultra-fine anaphase bridges to aid in their resolution.Adenovirus replaces mitotic checkpoint controls.What's the damage? The impact of pathogens on pathways that maintain host genome integrity Changing the ubiquitin landscape during viral manipulation of the DNA damage response.Downregulation of Mdm2 and Mdm4 enhances viral gene expression during adenovirus infection.The α2 helix in the DNA ligase IV BRCT-1 domain is required for targeted degradation of ligase IV during adenovirus infection.Using the E4orf6-Based E3 Ubiquitin Ligase as a Tool To Analyze the Evolution of Adenoviruses.Viral takeover of the host ubiquitin system.Emerging roles for ubiquitin in adenovirus cell entry.Adenovirus degradation of cellular proteins.CRL Ubiquitin Ligases and DNA Damage Response.Design stars: how small DNA viruses remodel the host nucleus.Combining Oncolytic Adenovirus with Radiation-A Paradigm for the Future of Radiosensitization.Analysis of the Cullin binding sites of the E4orf6 proteins of human adenovirus E3 ubiquitin ligases.Levels of the E2 interacting protein TopBP1 modulate papillomavirus maintenance stage replication.Role of E1B55K in E4orf6/E1B55K E3 ligase complexes formed by different human adenovirus serotypes.Functional cooperation between human adenovirus type 5 early region 4, open reading frame 6 protein, and cellular homeobox protein HoxB7.The DNA translocase activity of FANCM protects stalled replication forks.Adenovirus E4orf3 targets transcriptional intermediary factor 1γ for proteasome-dependent degradation during infection.Serotype-specific inactivation of the cellular DNA damage response during adenovirus infection.The E4orf6/E1B55K E3 ubiquitin ligase complexes of human adenoviruses exhibit heterogeneity in composition and substrate specificity.Take your PIKK: tumour viruses and DNA damage response pathways.The Human Adenovirus Type 5 E4orf6/E1B55K E3 Ubiquitin Ligase Complex Enhances E1A Functional Activity.The Human Adenovirus Type 5 E4orf6/E1B55K E3 Ubiquitin Ligase Complex Can Mimic E1A Effects on E2F.

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Adenovirus 12 E4orf6 inhibits ATR activation by promoting TOPBP1 degradation

http://www.wikidata.org/entity/Q33982295

description

2010 nî lūn-bûn

@nan

2010 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հունիսին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

Adenovirus 12 E4orf6 inhibits ATR activation by promoting TOPBP1 degradation

@ast

Adenovirus 12 E4orf6 inhibits ATR activation by promoting TOPBP1 degradation

@en

type

label

Adenovirus 12 E4orf6 inhibits ATR activation by promoting TOPBP1 degradation

@ast

Adenovirus 12 E4orf6 inhibits ATR activation by promoting TOPBP1 degradation

@en

prefLabel

Adenovirus 12 E4orf6 inhibits ATR activation by promoting TOPBP1 degradation

@ast

Adenovirus 12 E4orf6 inhibits ATR activation by promoting TOPBP1 degradation

@en

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PNAS.0914605107

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Proceedings of the National Academy of Sciences of the United States of America

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Adenovirus 12 E4orf6 inhibits ATR activation by promoting TOPBP1 degradation

@en

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A Malcolm R Taylor

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Andrew N Blackford

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Andrew S Turnell

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Iain M Morgan

http://www.w3.org/2001/XMLSchema#string

Natalie A Forrester

http://www.w3.org/2001/XMLSchema#string

Peter Groitl

http://www.w3.org/2001/XMLSchema#string

Rakesh N Patel

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Roger J A Grand

http://www.w3.org/2001/XMLSchema#string

Thomas Dobner

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P2860

ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage

Analysis of the adenovirus E1B-55K-anchored proteome reveals its link to ubiquitination machinery.

The DNA-damage response in human biology and disease

Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation

An adenovirus type 5 (Ad5) amplicon-based packaging cell line for production of high-capacity helper-independent deltaE1-E2-E3-E4 Ad5 vectors.

Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

Function and regulation of cullin-RING ubiquitin ligases

ATR and ATRIP: partners in checkpoint signaling

Induction of APOBEC3G ubiquitination and degradation by an HIV-1 Vif-Cul5-SCF complex

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12251-12256

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scholarly article

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10.1073/PNAS.0914605107

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P433

27

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107

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Grant S Stewart

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2010-06-21T00:00:00Z

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44691311

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20566845

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2901489

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