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DNA damage signaling assessed in individual cells in relation to the cell cycle phase and induction of apoptosisIn vitro anti-cancer activity of chamaejasmenin B and neochamaejasmin C isolated from the root of Stellera chamaejasme L.Evaluating the genotoxicity of topoisomerase-targeted antibioticsGenotoxic exposure during juvenile growth of mammary gland depletes stem cell activity and inhibits Wnt signaling.Combined genotoxic effects of a polycyclic aromatic hydrocarbon (B(a)P) and an heterocyclic amine (PhIP) in relation to colorectal carcinogenesis.Characterisation of an aerosol exposure system to evaluate the genotoxicity of whole mainstream cigarette smoke using the in vitro γH2AX assay by high content screeningGenome protective effect of metformin as revealed by reduced level of constitutive DNA damage signalingGenotoxic mode of action predictions from a multiplexed flow cytometric assay and a machine learning approach.Histone H2AX phosphorylation as a measure of DNA double-strand breaks and a marker of environmental stress and disease activity in lupus.Detection of γ-H2AX, a Biomarker for DNA Double-strand Breaks, in Urinary Bladders of N -Butyl- N -(4-Hydroxybutyl)-Nitrosamine-Treated RatsγH2AX and p53 responses in TK6 cells discriminate promutagens and nongenotoxicants in the presence of rat liver S9.Complementarity of phosphorylated histones H2AX and H3 quantification in different cell lines for genotoxicity screening.Evaluation of four human cell lines with distinct biotransformation properties for genotoxic screening.Interlaboratory evaluation of a multiplexed high information content in vitro genotoxicity assay.Absolute quantification of acetylation and phosphorylation of the histone variant H2AX upon ionizing radiation reveals distinct cellular responses in two cancer cell lines.Human cell line-dependent WC-Co nanoparticle cytotoxicity and genotoxicity: a key role of ROS production.Role of human sulfotransferase 1A1 and N-acetyltransferase 2 in the metabolic activation of 16 heterocyclic amines and related heterocyclics to genotoxicants in recombinant V79 cells.Carboxylated nanodiamonds are neither cytotoxic nor genotoxic on liver, kidney, intestine and lung human cell lines.Validation of high-throughput genotoxicity assay screening using γH2AX in-cell western assay on HepG2 cells.γH2AX assay as DNA damage biomarker for human population studies: defining experimental conditions.The γH2AX assay for genotoxic and nongenotoxic agents: comparison of H2AX phosphorylation with cell death response.Interpreting in vitro micronucleus positive results: simple biomarker matrix discriminates clastogens, aneugens, and misleading positive agents.Investigating the Generalizability of the MultiFlow® DNA Damage Assay and Several Companion Machine Learning Models with a Set of 103 Diverse Test Chemicals.Classification of in vitro genotoxicants using a novel multiplexed biomarker assay compared to the flow cytometric micronucleus test.Influence of selected anti-cancer drugs on the induction of DNA double-strand breaks and changes in gene expression in human hepatoma HepG2 cells.Advantages of evaluating γH2AX induction in non-clinical drug development.
P2860
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P2860
description
2011 nî lūn-bûn
@nan
2011 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Genotoxicity screening via the γH2AX by flow assay.
@ast
Genotoxicity screening via the γH2AX by flow assay.
@en
type
label
Genotoxicity screening via the γH2AX by flow assay.
@ast
Genotoxicity screening via the γH2AX by flow assay.
@en
prefLabel
Genotoxicity screening via the γH2AX by flow assay.
@ast
Genotoxicity screening via the γH2AX by flow assay.
@en
P2093
P1433
P1476
Genotoxicity screening via the γH2AX by flow assay
@en
P2093
P356
10.1016/J.MRFMMM.2011.07.001
P407
P577
2011-07-28T00:00:00Z