The oncoprotein gankyrin negatively regulates both p53 and RB by enhancing proteasomal degradation.
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Inhibition of apoptosis by oncogenic hepatitis B virus X protein: Implications for the treatment of hepatocellular carcinomaEvidence that proteasome-dependent degradation of the retinoblastoma protein in cells lacking A-type lamins occurs independently of gankyrin and MDM2.Gradually elevated expression of Gankyrin during human hepatocarcinogenesis and its clinicopathological significanceStabilization of the retinoblastoma protein by A-type nuclear lamins is required for INK4A-mediated cell cycle arrestProgression of cancer from indolent to aggressive despite antigen retention and increased expression of interferon-gamma inducible genesMolecular determinants of melanoma malignancy: selecting targets for improved efficacy of chemotherapyUp-regulated oncoprotein P28GANK correlates with proliferation and poor prognosis of human glioma.Mouse bites dogma: how mouse models are changing our views of how P53 is regulated in vivo.Synthetic Proteins Potently and Selectively Bind the Oncoprotein Gankyrin, Modulate Its Interaction with S6 ATPase, and Suppress Gankyrin/MDM2-Dependent Ubiquitination of p53.Deregulation of cyclin E meets dysfunction in p53: closing the escape hatch on breast cancer.Coping with stress: multiple ways to activate p53.Discovery of a small-molecule binder of the oncoprotein gankyrin that modulates gankyrin activity in the cellGankyrin has an antioxidative role through the feedback regulation of Nrf2 in hepatocellular carcinoma.Scratching the Surface: Resurfacing Proteins to Endow New Properties and Function.Nuclear factor kappa B and hepatitis viruses.Analysis of expression profiles of MAGE-A antigens in oral squamous cell carcinoma cell linesRegulatory mechanisms of tumor suppressor P16(INK4A) and their relevance to cancer.Loss of p53 and Ink4a/Arf cooperate in a cell autonomous fashion to induce metastasis of hepatocellular carcinoma cells.Gankyrin promotes the proliferation of gastric cancer and is associated with chemosensitivity.Expression of the oncoprotein gankyrin and phosphorylated retinoblastoma protein in human testis and testicular germ cell tumor.Gankyrin as a potential therapeutic target for cancer.Association of gankyrin protein expression with early clinical stages and insulin-like growth factor-binding protein 5 expression in human hepatocellular carcinoma.Vaccinia virus encodes a novel inhibitor of apoptosis that associates with the apoptosome.Gankyrin oncoprotein overexpression as a critical factor for tumor growth in human esophageal squamous cell carcinoma and its clinical significance.Gankyrin: a novel promising therapeutic target for hepatocellular carcinoma.Clinical implications of deregulated CDK4 and Cyclin D1 expression in patients with human hepatocellular carcinoma.Gankyrin Drives Malignant Transformation of Gastric Cancer and Alleviates Oxidative Stress via mTORC1 Activation
P2860
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P2860
The oncoprotein gankyrin negatively regulates both p53 and RB by enhancing proteasomal degradation.
description
2005 nî lūn-bûn
@nan
2005 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
The oncoprotein gankyrin negat ...... ncing proteasomal degradation.
@ast
The oncoprotein gankyrin negat ...... ncing proteasomal degradation.
@en
type
label
The oncoprotein gankyrin negat ...... ncing proteasomal degradation.
@ast
The oncoprotein gankyrin negat ...... ncing proteasomal degradation.
@en
prefLabel
The oncoprotein gankyrin negat ...... ncing proteasomal degradation.
@ast
The oncoprotein gankyrin negat ...... ncing proteasomal degradation.
@en
P2093
P356
P1433
P1476
The oncoprotein gankyrin negat ...... ncing proteasomal degradation.
@en
P2093
Hiroaki Higashitsuji
Jun Fujita
R John Mayer
P304
P356
10.4161/CC.4.10.2107
P577
2005-10-17T00:00:00Z