Autoantibodies to myelin basic protein catalyze site-specific degradation of their antigen.
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Optimizing therapeutics in the management of patients with multiple sclerosis: a review of drug efficacy, dosing, and mechanisms of actionNeed for a paradigm shift in therapeutic approaches to CNS injuryRoutes to covalent catalysis by reactive selection for nascent protein nucleophilesSuppression of ongoing experimental allergic encephalomyelitis in DA rats by novel peptide drug, structural part of human myelin basic protein 46-62.Physiological IgM class catalytic antibodies selective for transthyretin amyloid.Multiple sclerosis autoantigen myelin basic protein escapes control by ubiquitination during proteasomal degradationComparison of antibodies hydrolyzing myelin basic protein from the cerebrospinal fluid and serum of patients with multiple sclerosis.Specific anti-integrase abzymes from HIV-infected patients: a comparison of the cleavage sites of intact globular HIV integrase and two 20-mer oligopeptides corresponding to its antigenic determinants.Structural insight into the role of myelin basic protein in multiple sclerosis.The Pathogenesis of the Demyelinating Form of Guillain-Barre Syndrome (GBS): Proteo-peptidomic and Immunological Profiling of Physiological Fluids.IVIg treatment reduces catalytic antibody titers of renal transplanted patientsWhy specific anti-integrase antibodies from HIV-infected patients can efficiently hydrolyze 21-mer oligopeptide corresponding to antigenic determinant of human myelin basic protein.Comparison of DNA-hydrolyzing antibodies from the cerebrospinal fluid and serum of patients with multiple sclerosis.Autoantibodies with enzymatic properties in human autoimmune diseases.Evidence for the role of B cells and immunoglobulins in the pathogenesis of multiple sclerosisUbiquitin-independent proteosomal degradation of myelin basic protein contributes to development of neurodegenerative autoimmunitySystemic lupus erythematosus: molecular cloning and analysis of 22 individual recombinant monoclonal kappa light chains specifically hydrolyzing human myelin basic protein.Systemic lupus erythematosus: molecular cloning and analysis of recombinant monoclonal kappa light chain NGTA2-Me-pro-ChTr possessing two different activities-trypsin-like and metalloprotease.Specific Depletion of Myelin-Reactive B Cells via BCR-Targeting.DNA-hydrolysing activity of IgG antibodies from the sera of patients with diseases caused by different bacterial infections.Constitutive production of catalytic antibodies to a Staphylococcus aureus virulence factor and effect of infection.Comparison of Antibodies with Amylase Activity from Cerebrospinal Fluid and Serum of Patients with Multiple Sclerosis.Systemic lupus erythematosus: molecular cloning and analysis of recombinant monoclonal kappa light chain NGTA1-Me-pro with two metalloprotease active centers.Multitarget selection of catalytic antibodies with β-lactamase activity using phage display.Constant domain-regulated antibody catalysis.Liposome-encapsulated peptides protect against experimental allergic encephalitisMultiple sites of the cleavage of 21- and 25-mer encephalytogenic oligopeptides corresponding to human myelin basic protein (MBP) by specific anti-MBP antibodies from patients with systemic lupus erythematosusImmune response after intermittent minimally invasive intraocular pressure elevations in an experimental animal model of glaucomaGeneration of Catalytic Antibodies Is an Intrinsic Property of an Individual's Immune System: A Study on a Large Cohort of Renal Transplant Patients.Biochemical features of a catalytic antibody light chain, 22F6, prepared from human lymphocytes.Affinity and catalytic heterogeneity of polyclonal myelin basic protein-hydrolyzing IgGs from sera of patients with multiple sclerosisCD206-Targeted Liposomal Myelin Basic Protein Peptides in Patients with Multiple Sclerosis Resistant to First-Line Disease-Modifying Therapies: A First-in-Human, Proof-of-Concept Dose-Escalation StudyAntigen-specific proteolysis by hybrid antibodies containing promiscuous proteolytic light chains paired with an antigen-binding heavy chain.Polyreactive monoclonal autoantibodies in multiple sclerosis: functional selection from phage display library and characterization by deep sequencing analysis.Antibody-antigen pair probed by combinatorial approach and rational design: bringing together structural insights, directed evolution, and novel functionality.A Monoclonal Antibody to Cryptococcus neoformans Glucuronoxylomannan Manifests Hydrolytic Activity for Both Peptides and Polysaccharides.How human IgGs against DNA recognize oligonucleotides and DNA.How human IgGs against myelin basic protein (MBP) recognize oligopeptides and MBP.Antibody-Mediated Catalysis in Infection and Immunity.Antibodies as predictors of autoimmune diseases and cancer.
P2860
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P2860
Autoantibodies to myelin basic protein catalyze site-specific degradation of their antigen.
description
2005 nî lūn-bûn
@nan
2005 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Autoantibodies to myelin basic ...... degradation of their antigen.
@ast
Autoantibodies to myelin basic ...... degradation of their antigen.
@en
type
label
Autoantibodies to myelin basic ...... degradation of their antigen.
@ast
Autoantibodies to myelin basic ...... degradation of their antigen.
@en
prefLabel
Autoantibodies to myelin basic ...... degradation of their antigen.
@ast
Autoantibodies to myelin basic ...... degradation of their antigen.
@en
P2093
P2860
P50
P356
P1476
Autoantibodies to myelin basic ...... degradation of their antigen.
@en
P2093
Alain Friboulet
Alexander G Gabibov
Alexander Karavanov
Alexey A Belogurov
Bérangère Avalle
Daniel Thomas
Georgy B Telegin
Inna N Kurkova
Ivan I Vorobiev
Maria A Lagarkova
P2860
P304
P356
10.1073/PNAS.0509849103
P407
P577
2005-12-30T00:00:00Z