The A-loop, a novel conserved aromatic acid subdomain upstream of the Walker A motif in ABC transporters, is critical for ATP binding.
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Structure, function, and evolution of bacterial ATP-binding cassette systemsInter-domain communication mechanisms in an ABC importer: a molecular dynamics study of the MalFGK2E complexStructural and Functional Characterization of an Orphan ATP-Binding Cassette ATPase Involved in Manganese Utilization and Tolerance in Leptospira sppThe Nucleotide-Free State of the Multidrug Resistance ABC Transporter LmrA: Sulfhydryl Cross-Linking Supports a Constant Contact, Head-to-Tail Configuration of the Nucleotide-Binding DomainsJump into a New Fold-A Homology Based Model for the ABCG2/BCRP Multidrug TransporterEnergy transduction and alternating access of the mammalian ABC transporter P-glycoprotein.Catalytic transitions in the human MDR1 P-glycoprotein drug binding sites.Structures of the Carbon-Phosphorus Lyase Complex Reveal the Binding Mode of the NBD-like PhnK.Conserved allosteric hot spots in the transmembrane domains of cystic fibrosis transmembrane conductance regulator (CFTR) channels and multidrug resistance protein (MRP) pumps.Defective lipid transport and biosynthesis in recessive and dominant Stargardt macular degenerationOptimization of the degenerated interfacial ATP binding site improves the function of disease-related mutant cystic fibrosis transmembrane conductance regulator (CFTR) channels.Sequences in the nonconsensus nucleotide-binding domain of ABCG5/ABCG8 required for sterol transportRepositioning of Tyrosine Kinase Inhibitors as Antagonists of ATP-Binding Cassette Transporters in Anticancer Drug ResistanceInhibition of multidrug resistance-linked P-glycoprotein (ABCB1) function by 5'-fluorosulfonylbenzoyl 5'-adenosine: evidence for an ATP analogue that interacts with both drug-substrate-and nucleotide-binding sitesA Computational Approach towards the Understanding of Plasmodium falciparum Multidrug Resistance Protein 1MDR1 synonymous polymorphisms alter transporter specificity and protein stability in a stable epithelial monolayer.Molecular basis for differential nucleotide binding of the nucleotide-binding domain of ABC-transporter CvaB.Functionally important ATP binding and hydrolysis sites in Escherichia coli MsbA.CLC-0 and CFTR: chloride channels evolved from transporters.NMR and EPR studies of membrane transporters.ATP binding to two sites is necessary for dimerization of nucleotide-binding domains of ABC proteins.LibME-automatic extraction of 3D ligand-binding motifs for mechanistic analysis of protein-ligand recognition.An update on ABCB1 pharmacogenetics: insights from a 3D model into the location and evolutionary conservation of residues corresponding to SNPs associated with drug pharmacokinetics.Structure of ABC transporters.Importance of ABCC1 for cancer therapy and prognosis.The ability of molecular docking to unravel the controversy and challenges related to P-glycoprotein--a well-known, yet poorly understood drug transporter.Tyrosine kinase inhibitors as reversal agents for ABC transporter mediated drug resistance.Invited review: Architectures and mechanisms of ATP binding cassette proteins.Masitinib antagonizes ATP-binding cassette subfamily G member 2-mediated multidrug resistance.A novel MDR1 GT1292-3TG (Cys431Leu) genetic variation and its effect on P-glycoprotein biologic functions.The ABC transporters in Candidatus Liberibacter asiaticus.Tea nanoparticle, a safe and biocompatible nanocarrier, greatly potentiates the anticancer activity of doxorubicin.AFAL: a web service for profiling amino acids surrounding ligands in proteins.Two neonatal diabetes mutations on transmembrane helix 15 of SUR1 increase affinity for ATP and ADP at nucleotide binding domain 2.RloC: a wobble nucleotide-excising and zinc-responsive bacterial tRNaseA small ATPase protein of Arabidopsis, TGD3, involved in chloroplast lipid import.Proteins regulating the intercellular transfer and function of P-glycoprotein in multidrug-resistant cancer.Archaeal MutS5 tightly binds to Holliday junction similarly to eukaryotic MutSγ.A multidrug ABC transporter with a taste for GTP.Molecular characterization and structural implications of 25 new ABCB4 mutations in progressive familial intrahepatic cholestasis type 3 (PFIC3).
P2860
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P2860
The A-loop, a novel conserved aromatic acid subdomain upstream of the Walker A motif in ABC transporters, is critical for ATP binding.
description
2005 nî lūn-bûn
@nan
2005 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
The A-loop, a novel conserved ...... , is critical for ATP binding.
@ast
The A-loop, a novel conserved ...... , is critical for ATP binding.
@en
type
label
The A-loop, a novel conserved ...... , is critical for ATP binding.
@ast
The A-loop, a novel conserved ...... , is critical for ATP binding.
@en
prefLabel
The A-loop, a novel conserved ...... , is critical for ATP binding.
@ast
The A-loop, a novel conserved ...... , is critical for ATP binding.
@en
P2093
P2860
P1433
P1476
The A-loop, a novel conserved ...... , is critical for ATP binding.
@en
P2093
In-Wha Kim
Suresh V Ambudkar
Zuben E Sauna
P2860
P304
P356
10.1016/J.FEBSLET.2005.12.051
P407
P577
2005-12-22T00:00:00Z