Maternal obesity and overnutrition alter fetal growth rate and cotyledonary vascularity and angiogenic factor expression in the ewe.
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Placental Origins of Chronic Disease.Maternal obesity markedly increases placental fatty acid transporter expression and fetal blood triglycerides at midgestation in the ewe.Maternal obesity in ewes results in reduced fetal pancreatic β-cell numbers in late gestation and decreased circulating insulin concentration at term.Upregulation of growth signaling and nutrient transporters in cotyledons of early to mid-gestational nutrient restricted ewes.Low birth weight activates the renin-angiotensin system, but limits cardiac angiogenesis in early postnatal life.Impact of maternal obesity on fetal programming of cardiovascular diseaseEarly maternal undernutrition programs increased feed intake, altered glucose metabolism and insulin secretion, and liver function in aged female offspring.Effect of tocopherol supplementation during last trimester of pregnancy on mRNA abundances of interleukins and angiogenesis in ovine placenta and uterusMaternal nutrient restriction in the ewe from early to midgestation programs reduced steroidogenic enzyme expression and tended to reduce progesterone content of corpora lutea, as well as circulating progesterone in nonpregnant aged female offspringDiet reduction to requirements in obese/overfed ewes from early gestation prevents glucose/insulin dysregulation and returns fetal adiposity and organ development to control levels.The microvasculature: a target for nutritional programming and later risk of cardio-metabolic disease.Mechanisms by which maternal obesity programs offspring for obesity: evidence from animal studies.CELL BIOLOGY SYMPOSIUM: Impacts of maternal obesity on placental and gut inflammation and health.Developmental conditioning of the vasculature.Maternal obesity programs reduced leptin signaling in the pituitary and altered GH/IGF1 axis function leading to increased adiposity in adult sheep offspring.Placental phenotype and the insulin-like growth factors: resource allocation to fetal growth.A review of fundamental principles for animal models of DOHaD research: an Australian perspective.Angiogenesis in the placenta: the role of reactive oxygen species signalingExcessive backfat of sows at 109 d of gestation induces lipotoxic placental environment and is associated with declining reproductive performance.The microcirculation: a target for developmental priming.
P2860
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P2860
Maternal obesity and overnutrition alter fetal growth rate and cotyledonary vascularity and angiogenic factor expression in the ewe.
description
2010 nî lūn-bûn
@nan
2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Maternal obesity and overnutri ...... factor expression in the ewe.
@ast
Maternal obesity and overnutri ...... factor expression in the ewe.
@en
type
label
Maternal obesity and overnutri ...... factor expression in the ewe.
@ast
Maternal obesity and overnutri ...... factor expression in the ewe.
@en
prefLabel
Maternal obesity and overnutri ...... factor expression in the ewe.
@ast
Maternal obesity and overnutri ...... factor expression in the ewe.
@en
P2093
P2860
P1476
Maternal obesity and overnutri ...... factor expression in the ewe.
@en
P2093
Liren Zhang
Sarah M Hein
Stephen P Ford
P2860
P304
P356
10.1152/AJPREGU.00498.2009
P577
2010-04-28T00:00:00Z