Product dependence and bifunctionality compromise the ultrasensitivity of signal transduction cascades
about
An ultrasensitive sorting mechanism for EGF receptor endocytosisA hidden feedback in signaling cascades is revealedEnzyme Sequestration as a Tuning Point in Controlling Response Dynamics of Signalling NetworksNitrogen assimilation in Escherichia coli: putting molecular data into a systems perspectiveReciprocal regulation as a source of ultrasensitivity in two-component systems with a bifunctional sensor kinase.A fundamental trade-off in covalent switching and its circumvention by enzyme bifunctionality in glucose homeostasisBiosensor architectures for high-fidelity reporting of cellular signaling.Multisite protein phosphorylation makes a good threshold but can be a poor switch.Cell-signalling dynamics in time and space.Mixed analog/digital gonadotrope biosynthetic response to gonadotropin-releasing hormone.On the translocation of bacteria and their lipopolysaccharides between blood and peripheral locations in chronic, inflammatory diseases: the central roles of LPS and LPS-induced cell death.Signaling cascades transmit information downstream and upstream but unlikely simultaneously.From in vivo to in silico biology and back.Time-scale separation--Michaelis and Menten's old idea, still bearing fruit.GIV/Girdin is a rheostat that fine-tunes growth factor signals during tumor progression.Interplay between α-, β-, and γ-secretases determines biphasic amyloid-β protein level in the presence of a γ-secretase inhibitor.Why the phosphotransferase system of Escherichia coli escapes diffusion limitation.Sensitivity and robustness in covalent modification cycles with a bifunctional converter enzyme.Elasticity analysis and design for large metabolic responses produced by changes in enzyme activities.Realistic enzymology for post-translational modification: zero-order ultrasensitivity revisited.Robustness in Escherichia coli glutamate and glutamine synthesis studied by a kinetic model.Allosteric interactions and bifunctionality make the response of glutamine synthetase cascade system of Escherichia coli robust and ultrasensitive.Intrinsic feedbacks in MAPK signaling cascades lead to bistability and oscillations.Robust global sensitivity in multiple enzyme cascade system explains how the downstream cascade structure may remain unaffected by cross-talk.Mathematical modelling of miRNA mediated BCR.ABL protein regulation in chronic myeloid leukaemia vis-a-vis therapeutic strategies.Stochastic simulation of prokaryotic two-component signalling indicates stochasticity-induced active-state locking and growth-rate dependent bistability.Load-induced modulation of signal transduction networks.
P2860
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P2860
Product dependence and bifunctionality compromise the ultrasensitivity of signal transduction cascades
description
2002 nî lūn-bûn
@nan
2002 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
name
Product dependence and bifunct ...... f signal transduction cascades
@ast
Product dependence and bifunct ...... f signal transduction cascades
@en
Product dependence and bifunct ...... f signal transduction cascades
@nl
type
label
Product dependence and bifunct ...... f signal transduction cascades
@ast
Product dependence and bifunct ...... f signal transduction cascades
@en
Product dependence and bifunct ...... f signal transduction cascades
@nl
prefLabel
Product dependence and bifunct ...... f signal transduction cascades
@ast
Product dependence and bifunct ...... f signal transduction cascades
@en
Product dependence and bifunct ...... f signal transduction cascades
@nl
P2860
P50
P356
P1476
Product dependence and bifunct ...... f signal transduction cascades
@en
P2093
Luis Acerenza
P2860
P304
P356
10.1073/PNAS.022267399
P407
P577
2002-02-01T00:00:00Z