Atomistic insights into regulatory mechanisms of the HER2 tyrosine kinase domain: a molecular dynamics study.
about
Analysis of different HER-2 mutations in breast cancer progression and drug resistanceStructure-based network analysis of activation mechanisms in the ErbB family of receptor tyrosine kinases: the regulatory spine residues are global mediators of structural stability and allosteric interactions.Computational modeling of allosteric communication reveals organizing principles of mutation-induced signaling in ABL and EGFR kinases.The role of HER2 in cancer therapy and targeted drug deliveryCarboxyl-group footprinting maps the dimerization interface and phosphorylation-induced conformational changes of a membrane-associated tyrosine kinase.Analysis of Somatic Mutations in Cancer: Molecular Mechanisms of Activation in the ErbB Family of Receptor Tyrosine Kinases.A multiscale modeling approach to investigate molecular mechanisms of pseudokinase activation and drug resistance in the HER3/ErbB3 receptor tyrosine kinase signaling networkPrognostic impact of phosphorylated HER-2 in HER-2+ primary breast cancerMedicinal chemistry for 2020Structural systems biology and multiscale signaling models.Carboxyl group footprinting mass spectrometry and molecular dynamics identify key interactions in the HER2-HER3 receptor tyrosine kinase interface.Personalizing therapies for gastric cancer: molecular mechanisms and novel targeted therapiesMultiscale cancer modelingMolecular modeling of ErbB4/HER4 kinase in the context of the HER4 signaling network helps rationalize the effects of clinically identified HER4 somatic mutations on the cell phenotype.Molecular dynamics analysis of conserved hydrophobic and hydrophilic bond-interaction networks in ErbB family kinasesConformational flexibility of the ErbB2 ectodomain and trastuzumab antibody complex as revealed by molecular dynamics and principal component analysis.Structural investigations on mechanism of lapatinib resistance caused by HER-2 mutants.SAR and QSAR study on the bioactivities of human epidermal growth factor receptor-2 (HER2) inhibitors.Exploring the dynamics and interaction of a full ErbB2 receptor and Trastuzumab-Fab antibody in a lipid bilayer model using Martini coarse-grained force field.Conformational regulation of the EGFR kinase core by the juxtamembrane and C-terminal tail: a molecular dynamics study.
P2860
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P2860
Atomistic insights into regulatory mechanisms of the HER2 tyrosine kinase domain: a molecular dynamics study.
description
2009 nî lūn-bûn
@nan
2009 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի մարտին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Atomistic insights into regula ...... n: a molecular dynamics study.
@ast
Atomistic insights into regula ...... n: a molecular dynamics study.
@en
Atomistic insights into regula ...... n: a molecular dynamics study.
@nl
type
label
Atomistic insights into regula ...... n: a molecular dynamics study.
@ast
Atomistic insights into regula ...... n: a molecular dynamics study.
@en
Atomistic insights into regula ...... n: a molecular dynamics study.
@nl
prefLabel
Atomistic insights into regula ...... n: a molecular dynamics study.
@ast
Atomistic insights into regula ...... n: a molecular dynamics study.
@en
Atomistic insights into regula ...... n: a molecular dynamics study.
@nl
P2860
P1433
P1476
Atomistic insights into regula ...... n: a molecular dynamics study.
@en
P2093
Ravi Radhakrishnan
Shannon E Telesco
P2860
P304
P356
10.1016/J.BPJ.2008.12.3912
P407
P577
2009-03-01T00:00:00Z