Quantification of age-dependent somatic CAG repeat instability in Hdh CAG knock-in mice reveals different expansion dynamics in striatum and liver - Wikidata - awgldk - TriplyDB

Quantification of age-dependent somatic CAG repeat instability in Hdh CAG knock-in mice reveals different expansion dynamics in striatum and liver

Quantification of age-dependent somatic CAG repeat instability in Hdh CAG knock-in mice reveals different expansion dynamics in striatum and liver

http://www.wikidata.org/entity/Q34012758

about

Early alterations of brain cellular energy homeostasis in Huntington disease models Suppression of Somatic Expansion Delays the Onset of Pathophysiology in a Mouse Model of Huntington’s Disease A broad phenotypic screen identifies novel phenotypes driven by a single mutant allele in Huntington's disease CAG knock-in mice.The pathogenic exon 1 HTT protein is produced by incomplete splicing in Huntington's disease patients Msh2 acts in medium-spiny striatal neurons as an enhancer of CAG instability and mutant huntingtin phenotypes in Huntington's disease knock-in mice Making sense of intratumor genetic heterogeneity: altered frequency of androgen receptor CAG repeat length variants in breast cancer tissues.Mismatch repair genes Mlh1 and Mlh3 modify CAG instability in Huntington's disease mice: genome-wide and candidate approaches Chromosome substitution strain assessment of a Huntington's disease modifier locus Heterozygosity for a hypomorphic Polβ mutation reduces the expansion frequency in a mouse model of the Fragile X-related disorders.Spinocerebellar ataxia 7 (SCA7) in Indian population: predilection of ATXN7-CAG expansion mutation in an ethnic population MSH3 Promotes Dynamic Behavior of Trinucleotide Repeat Tracts In Vivo.The Repeat Expansion Diseases: The dark side of DNA repair.Genetic Contributors to Intergenerational CAG Repeat Instability in Huntington's Disease Knock-In Mice.Huntington's disease and the striatal medium spiny neuron: cell-autonomous and non-cell-autonomous mechanisms of disease Comparison of Huntington's disease CAG Repeat Length Stability in Human Motor Cortex and Cingulate Gyrus.High resolution time-course mapping of early transcriptomic, molecular and cellular phenotypes in Huntington's disease CAG knock-in mice across multiple genetic backgrounds.Intrinsic Disorder in Proteins with Pathogenic Repeat Expansions.The central role of DNA damage and repair in CAG repeat diseases.HttQ111/+ Huntington's Disease Knock-in Mice Exhibit Brain Region-Specific Morphological Changes and Synaptic Dysfunction.

P2860

Q23912810-3A7F2BEA-E052-459E-87E5-9F5F74776A4F Q27311065-972B2F33-274C-4527-A669-D5A49335651D Q28391627-160083BD-50E8-49FB-9E6C-30DCF8F52C6C Q33683726-D55D61F3-DA50-4F02-AB0E-C6B9F22F61F0 Q34412337-DABE8065-5921-4028-A0B3-E479A284269C Q34573232-A20FD7B1-A979-4EB6-A3CA-BB54C31AC44C Q35034398-2FBF98C2-09AC-46FC-A1C7-CACCE9AFCF85 Q35214662-DDD83A57-4536-4A3F-8420-D72A1BF043BF Q35463734-4FD4F310-A003-4CB2-AD9A-82AE7F48273A Q35564639-DCF9CC39-20F1-4C70-B4C4-82EAE4720012 Q35882334-17BF4CC3-90A7-4CE9-AC7D-A37E057A875E Q35909014-C6DB1B97-0B40-4264-A779-002AE54DC3A2 Q37621910-BEF8E86E-3750-49EB-A6AF-0C6FEA9AF505 Q37996350-475B82C0-1A4F-4917-86FD-A592A1E509AF Q45298302-92B81C95-BD83-45CD-AFF5-144F92C67917 Q45301191-2AC79C54-AC86-4516-894A-B23354AB3990 Q47351608-D2B59155-58C1-44AB-AFA5-769492132687 Q50118950-97B0FBAA-E1D2-4106-AC3D-33C35E6993A5 Q52685690-9D126CDB-B7C5-4BDB-B714-82A93072B6E9

P2860

Quantification of age-dependent somatic CAG repeat instability in Hdh CAG knock-in mice reveals different expansion dynamics in striatum and liver

http://www.wikidata.org/entity/Q34012758

description

2011 nî lūn-bûn

@nan

2011 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2011年の論文

@ja

2011年論文

@yue

2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

name

Quantification of age-dependen ...... dynamics in striatum and liver

@ast

Quantification of age-dependen ...... dynamics in striatum and liver

@en

Quantification of age-dependen ...... dynamics in striatum and liver

@nl

type

label

Quantification of age-dependen ...... dynamics in striatum and liver

@ast

Quantification of age-dependen ...... dynamics in striatum and liver

@en

Quantification of age-dependen ...... dynamics in striatum and liver

@nl

prefLabel

Quantification of age-dependen ...... dynamics in striatum and liver

@ast

Quantification of age-dependen ...... dynamics in striatum and liver

@en

Quantification of age-dependen ...... dynamics in striatum and liver

@nl

P1433

Q34012758-9F62B386-201E-4138-AE2D-7C84EA2FF1CF

P1476

Q34012758-D5146BCF-F61C-4B7E-918B-8696C9BB152D

P2093

Q34012758-048FE66C-5FD2-4C1E-9D74-A6F5F04DD6ED

Q34012758-7ECB55D4-52EF-4AB4-8D4D-B5B916B41A48

Q34012758-C83C8665-231D-4DA3-B28D-4CC2516BDD22

Q34012758-D31EB886-90D6-4946-A84A-5D126CB0A51E

P2860

Q34012758-02B30F9A-B3FE-4B4F-8C24-9D27F12AE13B

Q34012758-102ACE8D-65BA-4959-AD93-C9D2E3C3926C

Q34012758-216DFDD9-D124-4496-BC1E-BF9D96FF4642

Q34012758-38B58232-FD82-479F-9407-67C21B029004

Q34012758-3A8FB970-F3F8-487C-B6B2-B0CC86E91556

Q34012758-3B5909C8-0578-4883-B437-E168FF051EBA

Q34012758-3F199A7B-943A-478D-B047-354B9133F5F6

Q34012758-44352597-6067-4B49-968D-D44FFC796D09

Q34012758-4BEE8C30-414A-4676-A6E2-770219BAD4F7

Q34012758-4C7B8728-69FD-4F04-9ECF-FC8AF2A4EB77

P304

Q34012758-FF326717-35BA-4566-A622-302408AF0E37

P31

Q34012758-2C0B7CAF-4DB8-4EEF-A18D-37B734474F92

P356

Q34012758-9442EBFC-98DE-4E10-B585-87492918C846

P407

Q34012758-054B17BF-261D-4D01-BD16-45D6CF2CB414

P433

Q34012758-0275A159-EA57-4EB7-B2B4-A814F8D83BBC

P478

Q34012758-0688620C-EBEA-457C-A0DD-F20554D18844

P50

Q34012758-3FDF1BD4-C9C3-4415-8E36-0FF9CB111B88

P577

Q34012758-9750A8BA-AE86-4E1B-9A0B-D3D4BA829870

P5875

Q34012758-A44A49B6-1A85-48D4-A1A0-EFEE809D7B6B

P698

Q34012758-11D337B6-D7E2-4791-BAA2-707B5F34E443

P921

Q34012758-785EE834-FC61-4080-AC96-0D8FB40B6697

P932

Q34012758-EF5616CD-B189-4CA9-8F9D-6F3696CE6541

P356

JOURNAL.PONE.0023647

P1433

P1476

Quantification of age-dependen ...... dynamics in striatum and liver

@en

P2093

Jason C St Claire

http://www.w3.org/2001/XMLSchema#string

Jong-Min Lee

http://www.w3.org/2001/XMLSchema#string

Ricardo Mouro Pinto

http://www.w3.org/2001/XMLSchema#string

Vanessa C Wheeler

http://www.w3.org/2001/XMLSchema#string

P2860

Continuous and periodic expansion of CAG repeats in Huntington's disease R6/1 mice

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

The relationship between trinucleotide (CAG) repeat length and clinical features of Huntington's disease

Msh2 deficiency prevents in vivo somatic instability of the CAG repeat in Huntington disease transgenic mice

Long glutamine tracts cause nuclear localization of a novel form of huntingtin in medium spiny striatal neurons in HdhQ92 and HdhQ111 knock-in mice

Dramatic mutation instability in HD mouse striatum: does polyglutamine load contribute to cell-specific vulnerability in Huntington's disease?

Somatic CTG*CAG repeat instability in a mouse model for myotonic dystrophy type 1 is associated with changes in cell nuclearity and DNA ploidy.

Triplet repeat mutation length gains correlate with cell-type specific vulnerability in Huntington disease brain.

A novel approach to investigate tissue-specific trinucleotide repeat instability.

Intergenerational and striatal CAG repeat instability in Huntington's disease knock-in mice involve different DNA repair genes

P304

e23647

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1371/JOURNAL.PONE.0023647

http://www.w3.org/2001/XMLSchema#string

P407

P433

8

http://www.w3.org/2001/XMLSchema#string

P478

6

http://www.w3.org/2001/XMLSchema#string

P50

P577

2011-08-29T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

51625038

http://www.w3.org/2001/XMLSchema#string

P698

21897851

http://www.w3.org/2001/XMLSchema#string

P921

corpus striatum

P932

3163641

http://www.w3.org/2001/XMLSchema#string