Identification and functional characterization of a stable, centrally active derivative of the neurotensin (8-13) fragment as a potential first-in-class analgesic

Identification and functional characterization of a stable, centrally active derivative of the neurotensin (8-13) fragment as a potential first-in-class analgesic

Item
http://www.wikidata.org/entity/Q34012771
Increased Brain Neurotensin and NTSR2 Lead to Weak Nociception in NTSR3/Sortilin Knockout MiceConjugation of a brain-penetrant peptide with neurotensin provides antinociceptive propertiesThe discovery of indole full agonists of the neurotensin receptor 1 (NTSR1).Identification of N-[(5-{[(4-methylphenyl)sulfonyl]amino}-3-(trifluoroacetyl)-1H-indol-1-yl)acetyl]-l-leucine (NTRC-824), a neurotensin-like nonpeptide compound selective for the neurotensin receptor type 2Identification of 1-({[1-(4-fluorophenyl)-5-(2-methoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)cyclohexane carboxylic acid as a selective nonpeptide neurotensin receptor type 2 compoundIdentification of N-{[6-chloro-4-(2,6-dimethoxyphenyl)quinazolin-2-yl]carbonyl}-l-leucine (NTRC-808), a novel nonpeptide chemotype selective for the neurotensin receptor type 2The role of NTS2 in the development of tolerance to NT69L in mouse models for hypothermia and thermal analgesia.A novel stroke therapy of pharmacologically induced hypothermia after focal cerebral ischemia in mice.Acute and delayed protective effects of pharmacologically induced hypothermia in an intracerebral hemorrhage stroke model of miceThe anti-apoptotic role of neurotensin.Anticonvulsant neuropeptides as drug leads for neurological diseases.Development of a Peptide-derived orally-active kappa-opioid receptor agonist targeting peripheral pain.Structure-based evolution of subtype-selective neurotensin receptor ligands.Silaproline, a Silicon-Containing Proline Surrogate
P2860

Identification and functional characterization of a stable, centrally active derivative of the neurotensin (8-13) fragment as a potential first-in-class analgesic

Item
http://www.wikidata.org/entity/Q34012771
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Identification and functional ...... ntial first-in-class analgesic
@ast
Identification and functional ...... ntial first-in-class analgesic
@en
Identification and functional ...... ntial first-in-class analgesic
@nl
type
label
Identification and functional ...... ntial first-in-class analgesic
@ast
Identification and functional ...... ntial first-in-class analgesic
@en
Identification and functional ...... ntial first-in-class analgesic
@nl
prefLabel
Identification and functional ...... ntial first-in-class analgesic
@ast
Identification and functional ...... ntial first-in-class analgesic
@en
Identification and functional ...... ntial first-in-class analgesic
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P5875
P698
P932
P356
P1433
P1476
Identification and functional ...... ntial first-in-class analgesic
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P5875
P698
P932