Biphasic kill curve of isoniazid reveals the presence of drug-tolerant, not drug-resistant, Mycobacterium tuberculosis in the guinea pig.
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The role of the novel exopolyphosphatase MT0516 in Mycobacterium tuberculosis drug tolerance and persistenceThe HicA toxin from Burkholderia pseudomallei has a role in persister cell formationLocation of intra- and extracellular M. tuberculosis populations in lungs of mice and guinea pigs during disease progression and after drug treatmentDual-Reporter Mycobacteriophages (Φ2DRMs) Reveal Preexisting Mycobacterium tuberculosis Persistent Cells in Human SputumThe impact of mouse passaging of Mycobacterium tuberculosis strains prior to virulence testing in the mouse and guinea pig aerosol models.Comparison of the 'Denver regimen' against acute tuberculosis in the mouse and guinea pig.Characterization of a novel necrotic granuloma model of latent tuberculosis infection and reactivation in mice.Deficiency of double-strand DNA break repair does not impair Mycobacterium tuberculosis virulence in multiple animal models of infection.Local ischemia and increased expression of vascular endothelial growth factor following ocular dissemination of Mycobacterium tuberculosis.The potent bactericidal activity of streptomycin in the guinea pig model of tuberculosis ceases due to the presence of persistersLatent tuberculosis infection: myths, models, and molecular mechanismsDose-dependent activity of pyrazinamide in animal models of intracellular and extracellular tuberculosis infections.Effectiveness of tuberculosis chemotherapy correlates with resistance to Mycobacterium tuberculosis infection in animal modelsCharacterization and transcriptome analysis of Mycobacterium tuberculosis persisters.An update on the use of rifapentine for tuberculosis therapy.Expression of antimicrobial drug tolerance by attached communities of Mycobacterium tuberculosis.A new evolutionary and pharmacokinetic-pharmacodynamic scenario for rapid emergence of resistance to single and multiple anti-tuberculosis drugs.Pharmacokinetic mismatch does not lead to emergence of isoniazid- or rifampin-resistant Mycobacterium tuberculosis but to better antimicrobial effect: a new paradigm for antituberculosis drug scheduling.Drug treatment combined with BCG vaccination reduces disease reactivation in guinea pigs infected with Mycobacterium tuberculosis.Population modeling and simulation study of the pharmacokinetics and antituberculosis pharmacodynamics of isoniazid in lungs.Evaluation of a mouse model of necrotic granuloma formation using C3HeB/FeJ mice for testing of drugs against Mycobacterium tuberculosis.Rifapentine is not more active than rifampin against chronic tuberculosis in guinea pigsEradication of bacterial persisters with antibiotic-generated hydroxyl radicals.Roflumilast, a Type 4 Phosphodiesterase Inhibitor, Shows Promising Adjunctive, Host-Directed Therapeutic Activity in a Mouse Model of Tuberculosis.Upregulation of the phthiocerol dimycocerosate biosynthetic pathway by rifampin-resistant, rpoB mutant Mycobacterium tuberculosisBoromycin Kills Mycobacterial Persisters without Detectable ResistanceHost-directed therapy targeting the Mycobacterium tuberculosis granuloma: a reviewThioridazine lacks bactericidal activity in an animal model of extracellular tuberculosis.Targeting Drug-Sensitive and -Resistant Strains of Mycobacterium tuberculosis by Inhibition of Src Family Kinases Lowers Disease Burden and PathologyPotent rifamycin-sparing regimen cures guinea pig tuberculosis as rapidly as the standard regimenMycobacterial Protein Tyrosine Phosphatases A and B Inhibitors Augment the Bactericidal Activity of the Standard Anti-tuberculosis RegimenStringent Response Factors PPX1 and PPK2 Play an Important Role in Mycobacterium tuberculosis Metabolism, Biofilm Formation, and Sensitivity to Isoniazid In Vivo.Diverse drug-resistant subpopulations of Mycobacterium tuberculosis are sustained in continuous culture.A review of murine models of latent tuberculosis infection.Strain-dependent CNS dissemination in guinea pigs after Mycobacterium tuberculosis aerosol challenge.Nonclinical models for antituberculosis drug development: a landscape analysis.Delamanid Kills Dormant Mycobacteria In Vitro and in a Guinea Pig Model of Tuberculosis.Targeting Phenotypically Tolerant Mycobacterium tuberculosis.NOS2-deficient mice with hypoxic necrotizing lung lesions predict outcomes of tuberculosis chemotherapy in humans.Isoniazid Killing of Mycobacterium smegmatis NADH Pyrophosphatase Mutant at Single-Cell Level using Microfluidics and Time-Lapse Microscopy.
P2860
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P2860
Biphasic kill curve of isoniazid reveals the presence of drug-tolerant, not drug-resistant, Mycobacterium tuberculosis in the guinea pig.
description
2009 nî lūn-bûn
@nan
2009 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
name
Biphasic kill curve of isoniaz ...... uberculosis in the guinea pig.
@ast
Biphasic kill curve of isoniaz ...... uberculosis in the guinea pig.
@en
Biphasic kill curve of isoniaz ...... uberculosis in the guinea pig.
@nl
type
label
Biphasic kill curve of isoniaz ...... uberculosis in the guinea pig.
@ast
Biphasic kill curve of isoniaz ...... uberculosis in the guinea pig.
@en
Biphasic kill curve of isoniaz ...... uberculosis in the guinea pig.
@nl
prefLabel
Biphasic kill curve of isoniaz ...... uberculosis in the guinea pig.
@ast
Biphasic kill curve of isoniaz ...... uberculosis in the guinea pig.
@en
Biphasic kill curve of isoniaz ...... uberculosis in the guinea pig.
@nl
P2093
P356
P1476
Biphasic kill curve of isoniaz ...... uberculosis in the guinea pig.
@en
P2093
Charles A Peloquin
Eric L Nuermberger
Jacques H Grosset
Lee G Klinkenberg
Michael L Pinn
Petros C Karakousis
William R Bishai
Zahoor Ahmad
P304
P356
10.1086/605605
P407
P577
2009-10-01T00:00:00Z