about
In situ selectivity profiling and crystal structure of SML-8-73-1, an active site inhibitor of oncogenic K-Ras G12CRas uses the novel tumor suppressor RASSF1 as an effector to mediate apoptosisThe pro-apoptotic Ras effector Nore1 may serve as a Ras-regulated tumor suppressor in the lungRas-GRF1 signaling is required for normal beta-cell development and glucose homeostasisFarnesylation or geranylgeranylation? Efficient assays for testing protein prenylation in vitro and in vivoAnalysis of k-ras nuclear expression in fibroblasts and mesangial cellsGenetic alterations in K-ras and p53 cancer genes in lung neoplasms from B6C3F1 mice exposed to cumene.Activating K-Ras mutations outwith 'hotspot' codons in sporadic colorectal tumours - implications for personalised cancer medicine.Epithelial tissues have varying degrees of susceptibility to Kras(G12D)-initiated tumorigenesis in a mouse model.Heterogeneous proliferative potential of occult metastatic cells in bone marrow of patients with solid epithelial tumorsActivated KrasG¹²D is associated with invasion and metastasis of pancreatic cancer cells through inhibition of E-cadherin.While K-ras is essential for mouse development, expression of the K-ras 4A splice variant is dispensable.Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention.Mechanisms of membrane binding of small GTPase K-Ras4B farnesylated hypervariable region.Kras, Egfr, and Tp53 Mutations in B6C3F1/N Mouse and F344/NTac Rat Alveolar/Bronchiolar Carcinomas Resulting from Chronic Inhalation Exposure to Cobalt Metal.Conditional expression of oncogenic K-ras from its endogenous promoter induces a myeloproliferative disease.Oncogenic Ras in tumour progression and metastasis.MAZ-binding G4-decoy with locked nucleic acid and twisted intercalating nucleic acid modifications suppresses KRAS in pancreatic cancer cells and delays tumor growth in mice.Loss of the transcription factor GLI1 identifies a signaling network in the tumor microenvironment mediating KRAS oncogene-induced transformationK-RasG12D-induced T-cell lymphoblastic lymphoma/leukemias harbor Notch1 mutations and are sensitive to gamma-secretase inhibitors.Lapatinib resistance in HCT116 cells is mediated by elevated MCL-1 expression and decreased BAK activation and not by ERBB receptor kinase mutationMouse models of gastric cancer.Overexpressed vs mutated Kras in murine fibroblasts: a molecular phenotyping study.Isoform-specific ras functions in development and cancer.Concomitant inhibition of receptor tyrosine kinases and downstream AKT synergistically inhibited growth of KRAS/BRAF mutant colorectal cancer cells.Gene of the month: KRAS.KRAS mutation testing in clinical practice.Autocrine activation of an osteopontin-CD44-Rac pathway enhances invasion and transformation by H-RasV12.Specific and Efficient Regression of Cancers Harboring KRAS Mutation by Targeted RNA Replacement.Ras signaling through RASSF proteins.Tumor suppressor p16INK4a controls oncogenic K-Ras function in human pancreatic cancer cells.RKIP does not contribute to MAP kinase pathway silencing in the Merkel Cell Carcinoma cell line UISO.Oncolysis of pancreatic tumour cells by a gamma34.5-deleted HSV-1 does not rely upon Ras-activation, but on the PI 3-kinase pathway.Long-term vemurafenib treatment drives inhibitor resistance through a spontaneous KRAS G12D mutation in a BRAF V600E papillary thyroid carcinoma model.Molecular Simulations of Solved Co-crystallized X-Ray Structures Identify Action Mechanisms of PDEδ Inhibitors.Therapeutic targeting of oncogenic K-Ras by a covalent catalytic site inhibitorFunctional specificity of ras isoforms: so similar but so different.Inhibition of Ras oncogenic activity by Ras protooncogenes.Rare codons regulate KRas oncogenesis.Predominant K-ras codon 12 G --> A transition in chemically induced lung neoplasms in B6C3F1 mice.
P2860
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P2860
description
2000 nî lūn-bûn
@nan
2000 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
The importance of being K-Ras.
@ast
The importance of being K-Ras.
@en
The importance of being K-Ras.
@nl
type
label
The importance of being K-Ras.
@ast
The importance of being K-Ras.
@en
The importance of being K-Ras.
@nl
prefLabel
The importance of being K-Ras.
@ast
The importance of being K-Ras.
@en
The importance of being K-Ras.
@nl
P1433
P1476
The importance of being K-Ras.
@en
P2093
P304
P356
10.1016/S0898-6568(00)00084-X
P577
2000-07-01T00:00:00Z