Structure of a stapled peptide antagonist bound to nutlin-resistant Mdm2. - Wikidata - awgldk - TriplyDB

Structure of a stapled peptide antagonist bound to nutlin-resistant Mdm2.

Structure of a stapled peptide antagonist bound to nutlin-resistant Mdm2.

http://www.wikidata.org/entity/Q34035617

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Energetic Landscape of MDM2-p53 Interactions by Computational Mutagenesis of the MDM2-p53 Interaction The p53-Mdm2 interaction and the E3 ligase activity of Mdm2/Mdm4 are conserved from lampreys to humans Benzene Probes in Molecular Dynamics Simulations Reveal Novel Binding Sites for Ligand Design.How To Design a Successful p53-MDM2/X Interaction Inhibitor: A Thorough Overview Based on Crystal Structures.Functional characterization of p53 pathway components in the ancient metazoan Trichoplax adhaerens Avoiding drug resistance through extended drug target interfaces: a case for stapled peptides Medicinal Chemistry Strategies to Disrupt the p53-MDM2/MDMX Interaction.Peptides and peptidomimetics in the p53/MDM2/MDM4 circuitry - a patent review.Artificial Macrocycles as Potent p53-MDM2 Inhibitors.Structure-activity studies of Mdm2/Mdm4-binding stapled peptides comprising non-natural amino acids.Designing dual inhibitors of Mdm2/MdmX: Unexpected coupling of water with gatekeeper Y100/99.The Roles of MDM2 and MDMX in Cancer.

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P2860

Structure of a stapled peptide antagonist bound to nutlin-resistant Mdm2.

http://www.wikidata.org/entity/Q34035617

description

2014 nî lūn-bûn

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2014 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի օգոստոսին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

@wuu

name

Structure of a stapled peptide antagonist bound to nutlin-resistant Mdm2.

@ast

Structure of a stapled peptide antagonist bound to nutlin-resistant Mdm2.

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Structure of a stapled peptide antagonist bound to nutlin-resistant Mdm2.

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type

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Structure of a stapled peptide antagonist bound to nutlin-resistant Mdm2.

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Structure of a stapled peptide antagonist bound to nutlin-resistant Mdm2.

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Structure of a stapled peptide antagonist bound to nutlin-resistant Mdm2.

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prefLabel

Structure of a stapled peptide antagonist bound to nutlin-resistant Mdm2.

@ast

Structure of a stapled peptide antagonist bound to nutlin-resistant Mdm2.

@en

Structure of a stapled peptide antagonist bound to nutlin-resistant Mdm2.

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JOURNAL.PONE.0104914

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P1476

Structure of a stapled peptide antagonist bound to nutlin-resistant Mdm2.

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Chandra Verma

http://www.w3.org/2001/XMLSchema#string

Christopher J Brown

http://www.w3.org/2001/XMLSchema#string

Jantana Wongsantichon

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Quah Soo Tng

http://www.w3.org/2001/XMLSchema#string

Sharon Min Qi Chee

http://www.w3.org/2001/XMLSchema#string

Thomas L Joseph

http://www.w3.org/2001/XMLSchema#string

P2860

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

Mdm2 promotes the rapid degradation of p53

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix.

MolProbity: all-atom structure validation for macromolecular crystallography

Small-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: a novel approach for cancer therapy

Inhibition of nutlin-resistant HDM2 mutants by stapled peptides

In vitro selection of mutant HDM2 resistant to Nutlin inhibition

C-terminal substitution of MDM2 interacting peptides modulates binding affinity by distinctive mechanisms

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

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e104914

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scholarly article

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10.1371/JOURNAL.PONE.0104914

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8

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9

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Robert C Robinson

Farid J Ghadessy

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2014-08-12T00:00:00Z

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264797252

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25115702

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4130638

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