Basal LAT-diacylglycerol-RasGRP1 signals in T cells maintain TCRα gene expression
about
Novel tools to dissect the dynamic regulation of TCR signaling by the kinase Csk and the phosphatase CD45T-cell receptor α enhancer is inactivated in αβ T lymphocytes.The catalytic activity of the kinase ZAP-70 mediates basal signaling and negative feedback of the T cell receptor pathway.Dysregulation of RasGRP1 in rheumatoid arthritis and modulation of RasGRP3 as a biomarker of TNFα inhibitors.Activation of extracellular signal-regulated kinase but not of p38 mitogen-activated protein kinase pathways in lymphocytes requires allosteric activation of SOS.Ras and extracellular signal-regulated kinase signaling in thymocytes and T cells.Rasgrp1 mutation increases naive T-cell CD44 expression and drives mTOR-dependent accumulation of Helios⁺ T cells and autoantibodies.Regulation of ras exchange factors and cellular localization of ras activation by lipid messengers in T cells.Recent insights into the transcriptional control of the Tcra/Tcrd locus by distant enhancers during the development of T-lymphocytes.Tonic LAT-HDAC7 Signals Sustain Nur77 and Irf4 Expression to Tune Naive CD4 T Cells.Tonic Signals: Why Do Lymphocytes Bother?Tuning T Cell Signaling Sensitivity Alters the Behavior of CD4+ T Cells During an Immune Response.
P2860
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P2860
Basal LAT-diacylglycerol-RasGRP1 signals in T cells maintain TCRα gene expression
description
2011 nî lūn-bûn
@nan
2011 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Basal LAT-diacylglycerol-RasGRP1 signals in T cells maintain TCRα gene expression
@ast
Basal LAT-diacylglycerol-RasGRP1 signals in T cells maintain TCRα gene expression
@en
Basal LAT-diacylglycerol-RasGRP1 signals in T cells maintain TCRα gene expression
@nl
type
label
Basal LAT-diacylglycerol-RasGRP1 signals in T cells maintain TCRα gene expression
@ast
Basal LAT-diacylglycerol-RasGRP1 signals in T cells maintain TCRα gene expression
@en
Basal LAT-diacylglycerol-RasGRP1 signals in T cells maintain TCRα gene expression
@nl
prefLabel
Basal LAT-diacylglycerol-RasGRP1 signals in T cells maintain TCRα gene expression
@ast
Basal LAT-diacylglycerol-RasGRP1 signals in T cells maintain TCRα gene expression
@en
Basal LAT-diacylglycerol-RasGRP1 signals in T cells maintain TCRα gene expression
@nl
P2093
P2860
P1433
P1476
Basal LAT-diacylglycerol-RasGRP1 signals in T cells maintain TCRα gene expression
@en
P2093
Chih-wen Ou Yang
Evan Markegard
Evan Trager
Jeroen P Roose
Weiguo Zhang
P2860
P304
P356
10.1371/JOURNAL.PONE.0025540
P407
P50
P577
2011-09-26T00:00:00Z