Identification and characterization of essential genes in the human genome. - Wikidata - awgldk - TriplyDB

Identification and characterization of essential genes in the human genome.

Identification and characterization of essential genes in the human genome.

http://www.wikidata.org/entity/Q34045164

about

Regulation of CTNNB1 signaling in gastric cancer and stem cells TRAPP Complexes in Secretion and Autophagy Prion-like domains as epigenetic regulators, scaffolds for subcellular organization, and drivers of neurodegenerative disease Human Knockout Carriers: Dead, Diseased, Healthy, or Improved?RNA Interference in the Age of CRISPR: Will CRISPR Interfere with RNAi?Understanding Spatial Genome Organization: Methods and Insights Leveraging big data to transform target selection and drug discovery Genome-wide CRISPR-Cas9 Screens Reveal Loss of Redundancy between PKMYT1 and WEE1 in Glioblastoma Stem-like Cells A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes CRISPR-Cas9: from Genome Editing to Cancer Research Integrating next-generation sequencing into clinical oncology: strategies, promises and pitfalls Structural and functional insights into enzymes of the vitamin K cycle Two Distinct Types of E3 Ligases Work in Unison to Regulate Substrate Ubiquitylation Comparative Proteomics Reveals Strain-Specific β-TrCP Degradation via Rotavirus NSP1 Hijacking a Host Cullin-3-Rbx1 Complex Identification of oncogenic driver mutations by genome-wide CRISPR-Cas9 dropout screening Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival The BioGRID interaction database: 2017 update OGEE v2: an update of the online gene essentiality database with special focus on differentially essential genes in human cancer cell lines A CRISPR toolbox to study virus-host interactions Genomic variants reveal differential evolutionary constraints on human transglutaminases and point towards unrecognized significance of transglutaminase 2.CRISPR Interference Efficiently Induces Specific and Reversible Gene Silencing in Human iPSCs.RPA-Mediated Recruitment of the E3 Ligase RFWD3 Is Vital for Interstrand Crosslink Repair and Human Health.The U6 snRNA m6A Methyltransferase METTL16 Regulates SAM Synthetase Intron Retention.DHX9 suppresses RNA processing defects originating from the Alu invasion of the human genome.CRISPRi-based genome-scale identification of functional long noncoding RNA loci in human cells.When "N of 2" is not enough: integrating statistical and functional data in gene discovery.Genome-scale measurement of off-target activity using Cas9 toxicity in high-throughput screens Systematic mapping of functional enhancer-promoter connections with CRISPR interference.Serotonergic system antagonists target breast tumor initiating cells and synergize with chemotherapy to shrink human breast tumor xenografts.Systematic discovery of mutation-specific synthetic lethals by mining pan-cancer human primary tumor data.CRISPR/Cas9: From Genome Engineering to Cancer Drug Discovery Remodeling adipose tissue through in silico modulation of fat storage for the prevention of type 2 diabetes.Flexible CRISPR library construction using parallel oligonucleotide retrieval.A genome-wide CRISPR screen identifies a restricted set of HIV host dependency factors.Systematic comparison of CRISPR/Cas9 and RNAi screens for essential genes.Induced Pluripotent Stem Cells Meet Genome Editing A Comprehensive, CRISPR-based Functional Analysis of Essential Genes in Bacteria.Applications of CRISPR technologies in research and beyond.A CRISPR Dropout Screen Identifies Genetic Vulnerabilities and Therapeutic Targets in Acute Myeloid Leukemia.Induced protein degradation: an emerging drug discovery paradigm.

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P2860

Identification and characterization of essential genes in the human genome.

http://www.wikidata.org/entity/Q34045164

description

2015 nî lūn-bûn

@nan

2015 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2015 թվականի հոտեմբերին հրատարակված գիտական հոդված

@hy

2015年の論文

@ja

2015年学术文章

@wuu

2015年学术文章

@zh-cn

2015年学术文章

@zh-hans

2015年学术文章

@zh-my

2015年学术文章

@zh-sg

2015年學術文章

@yue

name

Identification and characterization of essential genes in the human genome.

@ast

Identification and characterization of essential genes in the human genome.

@en

Identification and characterization of essential genes in the human genome.

@nl

type

label

Identification and characterization of essential genes in the human genome.

@ast

Identification and characterization of essential genes in the human genome.

@en

Identification and characterization of essential genes in the human genome.

@nl

prefLabel

Identification and characterization of essential genes in the human genome.

@ast

Identification and characterization of essential genes in the human genome.

@en

Identification and characterization of essential genes in the human genome.

@nl

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Identification and characterization of essential genes in the human genome

@en

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Jenny J Wei

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Kevin M Krupczak

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Kıvanç Birsoy

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Nicholas W Hughes

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Yorick Post

http://www.w3.org/2001/XMLSchema#string

P2860

Ebola virus entry requires the cholesterol transporter Niemann-Pick C1

Haploid genetic screens in human cells identify host factors used by pathogens

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.

Passenger deletions generate therapeutic vulnerabilities in cancer

Multiplex genome engineering using CRISPR/Cas systems

Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma

Functional profiling of the Saccharomyces cerevisiae genome

Functional genomics of genes with small open reading frames (sORFs) in S. cerevisiae.

Role of duplicate genes in genetic robustness against null mutations

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scholarly article

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10.1126/SCIENCE.AAC7041

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David M Sabatini

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26472758

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4662922

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