Inhibitors of respiratory syncytial virus replication target cotranscriptional mRNA guanylylation by viral RNA-dependent RNA polymerase - Wikidata - awgldk - TriplyDB

Inhibitors of respiratory syncytial virus replication target cotranscriptional mRNA guanylylation by viral RNA-dependent RNA polymerase

Inhibitors of respiratory syncytial virus replication target cotranscriptional mRNA guanylylation by viral RNA-dependent RNA polymerase

http://www.wikidata.org/entity/Q34045568

about

Molecular targets for flavivirus drug discovery Initiation and regulation of paramyxovirus transcription and replication An unconventional pathway of mRNA cap formation by vesiculoviruses The RNA capping machinery as an anti-infective target Organization, Function, and Therapeutic Targeting of the Morbillivirus RNA-Dependent RNA Polymerase Complex The flavivirus NS5 protein is a true RNA guanylyltransferase that catalyzes a two-step reaction to form the RNA cap structure Inhibition of Respiratory Syncytial Virus Infections With Morpholino Oligomers in Cell Cultures and in Mice Virtual high-throughput screening identifies mycophenolic acid as a novel RNA capping inhibitor Inhibition of a metal-dependent viral RNA triphosphatase by decavanadate Inhibition of human parainfluenza virus type 3 infection by novel small molecules Histidine-mediated RNA transfer to GDP for unique mRNA capping by vesicular stomatitis virus RNA polymerase A single amino acid mutation (I1012F) of the RNA polymerase of marine viral hemorrhagic septicemia virus changes in vitro virulence to rainbow trout gill epithelial cells Pharmacologic advances in the treatment and prevention of respiratory syncytial virus.Evidence that the polymerase of respiratory syncytial virus initiates RNA replication in a nontemplated fashion.Interplay between innate immunity and negative-strand RNA viruses: towards a rational model Rational design of human metapneumovirus live attenuated vaccine candidates by inhibiting viral mRNA cap methyltransferase Viral load drives disease in humans experimentally infected with respiratory syncytial virus Human parainfluenza virus type 2 L protein regions required for interaction with other viral proteins and mRNA capping.Capping of vesicular stomatitis virus pre-mRNA is required for accurate selection of transcription stop-start sites and virus propagation A cell based high-throughput screening approach for the discovery of new inhibitors of respiratory syncytial virus Methyltransferase-defective avian metapneumovirus vaccines provide complete protection against challenge with the homologous Colorado strain and the heterologous Minnesota strain.A unique strategy for mRNA cap methylation used by vesicular stomatitis virus.Optimization of potent and selective quinazolinediones: inhibitors of respiratory syncytial virus that block RNA-dependent RNA-polymerase complex activity.Progress in understanding and controlling respiratory syncytial virus: still crazy after all these years (S)-N-(2,5-Dimethylphenyl)-1-(quinoline-8-ylsulfonyl)pyrrolidine-2-carboxamide as a small molecule inhibitor probe for the study of respiratory syncytial virus infection.Signature motifs of GDP polyribonucleotidyltransferase, a non-segmented negative strand RNA viral mRNA capping enzyme, domain in the L protein are required for covalent enzyme-pRNA intermediate formation The Interferon Type I/III Response to Respiratory Syncytial Virus Infection in Airway Epithelial Cells Can Be Attenuated or Amplified by Antiviral Treatment Respiratory syncytial virus polymerase can initiate transcription from position 3 of the leader promoter Respiratory syncytial virus: virology, reverse genetics, and pathogenesis of disease.N-terminally truncated C protein, CNDelta25, of human parainfluenza virus type 3 is a potent inhibitor of viral replication.The paramyxovirus polymerase complex as a target for next-generation anti-paramyxovirus therapeutics.Respiratory syncytial virus: prospects for new and emerging therapeutics.Identification of Interferon-Stimulated Gene Proteins That Inhibit Human Parainfluenza Virus Type 3 Recent Advances in Developing Antiviral Therapies for Respiratory Syncytial Virus.Structure-guided design of small-molecule therapeutics against RSV disease.Antiviral Efficacy of a Respiratory Syncytial Virus (RSV) Fusion Inhibitor in a Bovine Model of RSV Infection.Characterization of a respiratory syncytial virus L protein inhibitor.Polymerases of paramyxoviruses and pneumoviruses.Roles of Non-coding RNAs in Respiratory Syncytial Virus (RSV) Infection.Preclinical Characterization of PC786, an Inhaled Small-Molecule Respiratory Syncytial Virus L Protein Polymerase Inhibitor.

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Inhibitors of respiratory syncytial virus replication target cotranscriptional mRNA guanylylation by viral RNA-dependent RNA polymerase

http://www.wikidata.org/entity/Q34045568

description

2005 nî lūn-bûn

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2005 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2005 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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Inhibitors of respiratory sync ...... l RNA-dependent RNA polymerase

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Inhibitors of respiratory sync ...... l RNA-dependent RNA polymerase

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Inhibitors of respiratory sync ...... l RNA-dependent RNA polymerase

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Inhibitors of respiratory sync ...... l RNA-dependent RNA polymerase

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JVI.79.20.13105-13115.2005

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Journal of Virology

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Inhibitors of respiratory sync ...... l RNA-dependent RNA polymerase

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P2093

Bruno Simoneau

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Carol Lawetz

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Erika Scouten

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Florence Dô

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Gordon Bolger

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Gulrez Fazal

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Josée Bordeleau

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Lisette Lagacé

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Lyne Lamarre

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Marie-Josée Massariol

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P2860

Recombinant human mRNA cap methyltransferase binds capping enzyme/RNA polymerase IIo complexes

X-ray structure of human nucleoside diphosphate kinase B complexed with GDP at 2 A resolution

Fitting a mixture model by expectation maximization to discover motifs in biopolymers

Combining evidence using p-values: application to sequence homology searches

JPred: a consensus secondary structure prediction server

YM-53403, a unique anti-respiratory syncytial virus agent with a novel mechanism of action.

Immunoprophylaxis with palivizumab, a humanized respiratory syncytial virus monoclonal antibody, for prevention of respiratory syncytial virus infection in high risk infants: a consensus opinion.

Transcript initiation and 5'-end modifications are separable events during vesicular stomatitis virus transcription.

Identification of internal sequences in the 3' leader region of human respiratory syncytial virus that enhance transcription and confer replication processivity.

Respiratory syncytial virus: recent progress towards the discovery of effective prophylactic and therapeutic agents.

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13105-13115

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10.1128/JVI.79.20.13105-13115.2005

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79

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2005-10-01T00:00:00Z

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7575532

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16189012

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1235819

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