Emergence of protein kinase CK2 as a key target in cancer therapy - Wikidata - awgldk - TriplyDB

Emergence of protein kinase CK2 as a key target in cancer therapy

Emergence of protein kinase CK2 as a key target in cancer therapy

http://www.wikidata.org/entity/Q34046848

about

Substrate recognition and function of the R2TP complex in response to cellular stress Structural features underlying the selectivity of the kinase inhibitors NBC and dNBC: role of a nitro group that discriminates between CK2 and DYRK1A Low-density crystal packing of human protein kinase CK2 catalytic subunit in complex with resorufin or other ligands: a tool to study the unique hinge-region plasticity of the enzyme without packing bias Cell-permeable dual inhibitors of protein kinases CK2 and PIM-1: structural features and pharmacological potential Radiation protection following nuclear power accidents: a survey of putative mechanisms involved in the radioprotective actions of taurine during and after radiation exposure Effects of the CK2 inhibitors CX-4945 and CX-5011 on drug-resistant cells Tenfibgen ligand nanoencapsulation delivers bi-functional anti-CK2 RNAi oligomer to key sites for prostate cancer targeting using human xenograft tumors in mice A Synthetic Lethality Screen Using a Focused siRNA Library to Identify Sensitizers to Dasatinib Therapy for the Treatment of Epithelial Ovarian Cancer Spindle poisons and cell fate: a tale of two pathways.IL-6 stabilizes Twist and enhances tumor cell motility in head and neck cancer cells through activation of casein kinase 2.Pre-clinical characterization of CX-4945, a potent and selective small molecule inhibitor of CK2 for the treatment of cancer.Mechanism and efficacy of sub-50-nm tenfibgen nanocapsules for cancer cell-directed delivery of anti-CK2 RNAi to primary and metastatic squamous cell carcinoma.Proteomic profile of pre - B2 lymphoblasts from children with acute lymphoblastic leukemia (ALL) in relation with the translocation (12; 21)Protein kinase CK2 localizes to sites of DNA double-strand break regulating the cellular response to DNA damage Protein kinase CK2 inhibition induces cell death via early impact on mitochondrial function.CK2 phosphorylates Sec31 and regulates ER-To-Golgi trafficking Mining CK2 in cancer PIM-1 modulates cellular senescence and links IL-6 signaling to heterochromatin formation.ck2-dependent phosphorylation of progesterone receptors (PR) on Ser81 regulates PR-B isoform-specific target gene expression in breast cancer cells.Preclinical evaluation of cyclin dependent kinase 11 and casein kinase 2 survival kinases as RNA interference targets for triple negative breast cancer therapy MEK inhibitor PD-0325901 overcomes resistance to CK2 inhibitor CX-4945 and exhibits anti-tumor activity in head and neck cancer.Casein kinase 2α regulates glioblastoma brain tumor-initiating cell growth through the β-catenin pathway Tenfibgen-DMAT Nanocapsule Delivers CK2 Inhibitor DMAT to Prostate Cancer Xenograft Tumors Causing Inhibition of Cell Proliferation.Nanoencapsulated anti-CK2 small molecule drug or siRNA specifically targets malignant cancer but not benign cells Developmental and growth defects in mice with combined deficiency of CK2 catalytic genes.Casein kinase 2α regulates multidrug resistance-associated protein 1 function via phosphorylation of Thr249.The Selectivity of CK2 Inhibitor Quinalizarin: A Reevaluation.Identification of a Potent Allosteric Inhibitor of Human Protein Kinase CK2 by Bacterial Surface Display Library Screening.Protein kinase CK2 is a critical regulator of epithelial homeostasis in chronic intestinal inflammation.Protein kinase CK2α catalytic subunit is overexpressed and serves as an unfavorable prognostic marker in primary hepatocellular carcinoma.Phosphorylation of ribosomal protein S3 and antiapoptotic TRAF2 protein mediates radioresistance in non-small cell lung cancer cells.Colon cancer cell invasion is promoted by protein kinase CK2 through increase of endothelin-converting enzyme-1c protein stability.Systemic administration of antisense oligonucleotides simultaneously targeting CK2α and α' subunits reduces orthotopic xenograft prostate tumors in mice.Casein kinase II is required for proper cell division and acts as a negative regulator of centrosome duplication in Caenorhabditis elegans embryos.CK2 targeted RNAi therapeutic delivered via malignant cell-directed tenfibgen nanocapsule: dose and molecular mechanisms of response in xenograft prostate tumors.Nuclear localization of the CK2α-subunit correlates with poor prognosis in clear cell renal cell carcinoma.CK2 Molecular Targeting-Tumor Cell-Specific Delivery of RNAi in Various Models of Cancer.Expanding roles of protein kinase CK2 in regulating plant growth and development.Casein kinase: the triple meaning of a misnomer.A fragment-based approach leading to the discovery of a novel binding site and the selective CK2 inhibitor CAM4066.

P2860

Q26824496-FE465340-C727-42ED-9155-D7B69A7E76E6 Q27670633-AE101503-034C-479E-9057-2651DB86D3C6 Q27681892-2D549621-0B30-425E-A78C-A1C094770D4D Q27688944-F59A8F17-8056-499E-A0E9-FB631E882A70 Q28387506-1115EB41-382D-43ED-A884-3B8BD994C5B0 Q28485087-6B69368C-F6C4-431E-97E5-9F515DC8784D Q28543800-FA5AA30F-8FE1-40AC-B090-0CE275DC88B9 Q28551341-DA7B3CCC-434F-4C80-B0E9-B1BAFDF0B7D5 Q30431071-A8B0E0DD-40DE-4C49-8C1D-B89B3AFEDD8E Q33894901-0A794B21-57E7-406F-90E3-320AA6791458 Q33960547-EDCB31AB-A08F-4192-8F9F-842C3035FAD7 Q34020978-44DA6AAF-C67B-416F-8BBB-BDFDB2D6F730 Q34027272-332D3084-5535-4B38-92FC-80057413AFB1 Q34190250-57C57385-1323-4927-8E7E-26C47B835075 Q34353356-48077E9F-454C-4DB0-B63F-3F5F430A491E Q34563010-C4C55864-26A7-4BD5-874E-0158E13CCC9D Q34776090-C644BE9C-9E6D-444D-8624-E8D1FBBDAD73 Q35093045-56F8BDEA-0CA4-410F-B417-929D28AB0430 Q35096710-7645B097-C52B-4AA2-9118-0DAEFABAA6CF Q35132090-4177EE2C-E356-476A-A047-ECA247BCFAE4 Q35197507-304222E1-0F7D-4618-85AF-6DA76CBCF947 Q35205600-67256C7C-691D-4AD5-A760-06A9F02DB833 Q35423247-F6A5CEE3-3DC4-4CC2-827D-12F82DE963CA Q35577635-469262A4-ADEB-4C7D-8F3F-9F2AEB8CB317 Q36095842-0232B209-C172-443E-8FAF-10A7EFCD4FB4 Q36174733-719D3CEC-D445-4069-8D8D-8E0AAD4A1450 Q36237271-6FCA25BB-BDA6-42BD-8807-A991DB9C55AB Q36244285-2451BF43-F813-4D0F-88CC-0EDDA0CCB79F Q36455179-B5B64208-3BFF-4FA8-88B2-E5EDA2BA87D4 Q36544222-EA53A7F2-163E-4998-B4B8-E34A849F393C Q36579445-E527E450-6B0D-4937-A004-B132BE788985 Q36618993-65A8F24A-33F7-44DB-80B9-8D78EAE749A8 Q37487082-F4E95BC1-7BA9-449D-969C-84641E58CA37 Q37612443-A65A50C2-E09D-4DD7-A2B1-AAA1573F2692 Q37641686-25D07556-7043-4943-988C-CFD0E1BA5D46 Q37702141-60F4AF04-66F6-4898-8F9C-DE3D664F2B9D Q37731329-603BF9E9-0F3B-4E51-9F2B-FB0E139EAE56 Q38168824-B777EC24-9B75-4F1F-B270-46ABDC48630B Q38211598-91EFF534-A8A0-4037-9A90-234CCBD49B01 Q38557670-6AE58F52-BC76-42F6-B080-B133761CC6A2

P2860

Emergence of protein kinase CK2 as a key target in cancer therapy

http://www.wikidata.org/entity/Q34046848

description

2010 nî lūn-bûn

@nan

2010 թուականի Մայիսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի մայիսին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

Emergence of protein kinase CK2 as a key target in cancer therapy

@ast

Emergence of protein kinase CK2 as a key target in cancer therapy

@en

Emergence of protein kinase CK2 as a key target in cancer therapy

@nl

type

label

Emergence of protein kinase CK2 as a key target in cancer therapy

@ast

Emergence of protein kinase CK2 as a key target in cancer therapy

@en

Emergence of protein kinase CK2 as a key target in cancer therapy

@nl

prefLabel

Emergence of protein kinase CK2 as a key target in cancer therapy

@ast

Emergence of protein kinase CK2 as a key target in cancer therapy

@en

Emergence of protein kinase CK2 as a key target in cancer therapy

@nl

P1433

Q34046848-94EDD2B7-BD54-405A-958A-EA43949D92EF

P1476

Q34046848-2FBDCCAB-C686-4C0A-9BD0-DDCAE317109B

P2093

Q34046848-2FB2006B-B862-4374-871A-605C21E6C2BA

Q34046848-41263BC6-2EAD-45BE-85C6-03FA3228F7DD

Q34046848-63F39E45-BD5F-46FF-8C05-3B555E028A8F

Q34046848-94DACF94-0829-44AD-B53F-8AB82200FB39

Q34046848-C3871CA8-0186-4CB7-8A4A-DBAE2A59D00F

Q34046848-FA1FEF64-28C3-4EB2-A7C6-FD8F710C1D1B

P2860

Q34046848-00A88665-7A8F-4A0B-B296-FF33D70D1A5F

Q34046848-0312CCEF-DD8E-463C-91DB-DF8CEA6408A3

Q34046848-045433DB-9555-4EB4-A7CB-39B21C0A5CD8

Q34046848-089BE5EB-36AA-42D4-8EA9-784E3744B76D

Q34046848-0B36EEC7-E285-40B0-838E-03F0707B0EA0

Q34046848-0D1EC527-4FB8-48C1-B3CE-32492CB2F8E9

Q34046848-0FEF9B86-4371-47EA-9D85-B54130C27EC4

Q34046848-1125006C-0F54-4FB8-B1EA-7CA1FCB62954

Q34046848-114948A7-34F3-4D3E-8ECB-0EB191844F87

Q34046848-18B08A25-98D7-4671-9E3C-EAF45CDE863D

P304

Q34046848-E29A93DE-7EDF-44D4-9271-32FCD49AD569

P31

Q34046848-D83757BF-661C-4369-A3E7-D9E8E4B925D0

P356

Q34046848-EF7D8C4A-6BDC-4920-80A2-85A4EFD9B94C

P433

Q34046848-1FA985A2-FCB8-42A1-BB6A-A2766BA131DD

P478

Q34046848-B72C44DF-52E0-42A3-A6DD-A6153A8709A1

P50

Q34046848-B53AE869-7356-4F3A-A2BE-DCB3197FE66A

P577

Q34046848-660D1722-AE1A-47F1-811A-4956023C637C

P5875

Q34046848-24A28FD7-49FC-4091-8540-FD1C19EE7660

P698

Q34046848-50C7035C-0E20-46D2-99F0-AE7DF74D9074

P932

Q34046848-1C1844D2-5530-4AC6-BEC9-CB0E290B84FE

P356

P1433

P1476

Emergence of protein kinase CK2 as a key target in cancer therapy

@en

P2093

Betsy T Kren

http://www.w3.org/2001/XMLSchema#string

Carter Van Waes

http://www.w3.org/2001/XMLSchema#string

Gretchen Unger

http://www.w3.org/2001/XMLSchema#string

Joel Slaton

http://www.w3.org/2001/XMLSchema#string

Khalil Ahmed

http://www.w3.org/2001/XMLSchema#string

Zhong Chen

http://www.w3.org/2001/XMLSchema#string

P2860

The Hallmarks of Cancer

The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation

Protein kinase CK2 in health and disease: CK2: the kinase controlling the Hsp90 chaperone machinery

Caspase-2 primes cancer cells for TRAIL-mediated apoptosis by processing procaspase-8

Crystal structure of the human protein kinase CK2 regulatory subunit reveals its zinc finger-mediated dimerization

Subcellular localization of protein kinase CK2. A key to its function?

Tumor necrosis factor alpha-induced phosphorylation of RelA/p65 on Ser529 is controlled by casein kinase II

Proliferation, cell cycle and apoptosis in cancer

A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1

Protein kinases. 4. Protein kinase CK2: an enzyme with multiple substrates and a puzzling regulation

P304

187-195

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1002/BIOF.96

http://www.w3.org/2001/XMLSchema#string

P433

3

http://www.w3.org/2001/XMLSchema#string

P478

36

http://www.w3.org/2001/XMLSchema#string

P50

P577

2010-05-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

44659037

http://www.w3.org/2001/XMLSchema#string

P698

20533398

http://www.w3.org/2001/XMLSchema#string

P932

2916697

http://www.w3.org/2001/XMLSchema#string