Engineering stable peptide toxins by means of backbone cyclization: stabilization of the alpha-conotoxin MII. - Wikidata - awgldk - TriplyDB

Engineering stable peptide toxins by means of backbone cyclization: stabilization of the alpha-conotoxin MII.

Engineering stable peptide toxins by means of backbone cyclization: stabilization of the alpha-conotoxin MII.

http://www.wikidata.org/entity/Q34048086

about

From Mollusks to Medicine: A Venomics Approach for the Discovery and Characterization of Therapeutics from Terebridae Peptide Toxins Cyclic Peptides Arising by Evolutionary Parallelism via Asparaginyl-Endopeptidase-Mediated Biosynthesis The α-defensin salt-bridge induces backbone stability to facilitate folding and confer proteolytic resistance Semienzymatic Cyclization of Disulfide-rich Peptides Using Sortase A Transforming conotoxins into cyclotides: Backbone cyclization of P-superfamily conotoxins NMR and protein structure in drug design: application to cyclotides and conotoxins.Biological synthesis of circular polypeptides Trisubstituted (E)-alkene dipeptide isosteres as beta-turn promoters in the gramicidin S cyclodecapeptide scaffold.Knottin cyclization: impact on structure and dynamics.High throughput electrophysiology with Xenopus oocytes Alpha-conotoxins as pharmacological probes of nicotinic acetylcholine receptors.Sortase A-mediated crosslinked short-chain dehydrogenases/reductases as novel biocatalysts with improved thermostability and catalytic efficiency Macrocyclic Antimicrobial Peptides Engineered from ω-Conotoxin.Designed α-sheet peptides inhibit amyloid formation by targeting toxic oligomers.Protease-resistant peptide ligands from a knottin scaffold library.Solution structure of a sponge-derived cystine knot peptide and its notable stability.Sortase-catalyzed transformations that improve the properties of cytokines Spider peptide toxins as leads for drug development.Recombinant expression of backbone-cyclized polypeptides.Chemical re-engineering of chlorotoxin improves bioconjugation properties for tumor imaging and targeted therapy.Biosynthesis and antimicrobial evaluation of backbone-cyclized α-defensins Tailored delivery of analgesic ziconotide across a blood brain barrier model using viral nanocontainers.Phage-displayed macrocyclic glycopeptide libraries.Less is More: Design of a Highly Stable Disulfide-Deleted Mutant of Analgesic Cyclic α-Conotoxin Vc1.1.Ribosomal Synthesis of Natural-Product-Like Bicyclic Peptides in Escherichia coli.Cyclisation increases the stability of the sea anemone peptide APETx2 but decreases its activity at acid-sensing ion channel 3 Highly Constrained Bicyclic Scaffolds for the Discovery of Protease-Stable Peptides via mRNA Display.Cyclic thrombospondin-1 mimetics: grafting of a thrombospondin sequence into circular disulfide-rich frameworks to inhibit endothelial cell migration.CyBase: a database of cyclic protein sequences and structures, with applications in protein discovery and engineering High Proteolytic Resistance of Spider-Derived Inhibitor Cystine Knots Unfolding the fold of cyclic cysteine-rich peptides.Serum Stability and Affinity Optimization of an M2 Macrophage-Targeting Peptide (M2pep).Development of peptides specifically modulating the activity of KLK2 and KLK3.Integrating the discovery pipeline for novel compounds targeting ion channels.Scanning mutagenesis of alpha-conotoxin Vc1.1 reveals residues crucial for activity at the alpha9alpha10 nicotinic acetylcholine receptor Intein-mediated backbone cyclization of VP1 protein enhanced protection of CVB3-induced viral myocarditis.Converting disulfide bridges in native peptides to stable methylene thioacetals.Making and breaking peptide bonds: protein engineering using sortase.Synthetic α-conotoxin mutants as probes for studying nicotinic acetylcholine receptors and in the development of novel drug leads.P/Q-type calcium channel modulators.

P2860

Q26750941-2FCDD06A-E9D4-4DAB-B5A2-836343F36092 Q27670873-4E5C85E9-9F9E-4129-877F-C0F8815B67C5 Q27676939-39732DA0-9B30-4CA2-A902-F9027DFB8489 Q27681346-7B36532B-8413-4886-B65A-4C6AEA9ABC6A Q27701553-DE48A937-2764-465E-80AF-A01B4FF30DC7 Q30399297-E69F43B0-3E3C-4012-8800-F08D114EBE8D Q30418154-0C4C6527-B998-4BE7-9C5A-29CD548F459C Q33259315-7D0F1A38-DA9E-480E-B8A0-C9B9B83184CC Q33392477-67B6A664-D415-4B3B-B9CD-FC6904B33CF2 Q33400496-D53C6AFB-55F4-402F-BBFF-2C87067B6C15 Q33621205-9C3AD58B-8108-438C-8382-2C3CC73D2A4A Q33780021-0D17DC01-5BCC-4700-9600-BF55EF96A0C9 Q33795132-544F8913-263F-4110-BFD8-553BB03246BF Q33878699-F4C17C4C-28A9-406C-BF29-D79058729C61 Q33912692-6D34019D-A8A5-4C20-9A86-A8916822F122 Q34027694-D2E25EFA-58CE-4CEB-B606-5ED9800FA1D3 Q34602642-5BE93F23-EEE6-453D-B965-CAF7DD4A6A7A Q34620046-B68F828B-FD14-4B9E-BAE5-0F701AADBCD6 Q34871830-6AFFBD00-3F04-4C69-9F04-858109200307 Q34917475-F1992246-B705-4E6E-840C-68CC09F7DB83 Q35610217-B3CCD357-F23F-4F69-8B39-4146EE07CEFB Q35733724-CC872CB9-C596-4387-837B-F085FF387ACF Q35926997-B52EF204-0CD0-447A-BA45-B01EDB2FB939 Q35974234-2F5A43E9-A97B-4CA4-970D-36FEBF71E8A5 Q36070579-BF9CAEBB-935C-4ED9-8BF3-91F5D04C819C Q36126184-8E3857E3-9C8B-4BA5-B6EF-537B2354B57E Q36266199-9075EE63-A6B1-405E-B6CB-AB1D94CDD92D Q36321375-F79A9E84-E367-405F-A888-9190467F02CE Q36454443-6E0B87F0-2ABD-4E54-A0D4-CB718D392731 Q36457208-AEE847B7-C394-4082-9B2A-EB180B8C1A06 Q36470454-1305B26E-02CA-44E7-9DE4-3E16E89A68EB Q37045947-11965915-0AAC-4680-AAD8-58E013A980B1 Q37216674-B7006598-A0E1-41EF-A10A-9FE720ACFBB3 Q37234699-644951CC-3EB6-4245-816C-1C2A97E7A8BF Q37339057-92AE3767-ACD9-409A-AD81-C3D8895411C4 Q37620427-BCAD4197-4BE3-4AEF-AC1C-2F7E61344462 Q37707861-D8C86F8C-B5C5-4361-A41B-5A7753A4FF00 Q37871538-357D7A93-F57C-4E1B-B15A-B5A8342F41D4 Q37954299-AFD09948-D106-4AEC-B259-A75936A1362C Q38016449-B1EF8329-F9C8-43D4-B8A5-4E9DD447E163

P2860

Engineering stable peptide toxins by means of backbone cyclization: stabilization of the alpha-conotoxin MII.

http://www.wikidata.org/entity/Q34048086

description

2005 nî lūn-bûn

@nan

2005 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2005 թվականի սեպտեմբերին հրատարակված գիտական հոդված

@hy

2005年の論文

@ja

2005年論文

@yue

2005年論文

@zh-hant

2005年論文

@zh-hk

2005年論文

@zh-mo

2005年論文

@zh-tw

2005年论文

@wuu

name

Engineering stable peptide tox ...... on of the alpha-conotoxin MII.

@ast

Engineering stable peptide tox ...... on of the alpha-conotoxin MII.

@en

Engineering stable peptide tox ...... on of the alpha-conotoxin MII.

@nl

type

label

Engineering stable peptide tox ...... on of the alpha-conotoxin MII.

@ast

Engineering stable peptide tox ...... on of the alpha-conotoxin MII.

@en

Engineering stable peptide tox ...... on of the alpha-conotoxin MII.

@nl

prefLabel

Engineering stable peptide tox ...... on of the alpha-conotoxin MII.

@ast

Engineering stable peptide tox ...... on of the alpha-conotoxin MII.

@en

Engineering stable peptide tox ...... on of the alpha-conotoxin MII.

@nl

P1433

Q34048086-E5BCD4DF-9C8B-4E15-BECC-B7B34501290B

P1476

Q34048086-3796C6CA-4186-45FA-9D98-64BBDD3A84EE

P2093

Q34048086-1F268FF8-FFC6-4B15-8FF2-3E41216BF547

Q34048086-840898ED-FD5F-4901-A55E-2C9F7ABAFE55

Q34048086-D4C80191-5035-4A56-9924-B8F34CB1A6F7

P2860

Q34048086-0DF502F9-D561-4A05-9E81-4A24C4460A07

Q34048086-16C747AA-2C17-4416-A34E-CF89C195B2CE

Q34048086-17055BBF-9D36-4C2E-9C74-535EBEA3CCDF

Q34048086-1B154DE2-5931-4ECB-9974-3F58D92433C3

Q34048086-2B8C5F53-E9C5-4209-86CC-D20A1D862C98

Q34048086-3EF70005-D4DA-4B0B-AFA5-0F3B24968CFA

Q34048086-5076C09D-DD41-4148-97CE-E3952960A66D

Q34048086-5C7884F9-F7E2-46A9-9E3F-235EE2417FB5

Q34048086-6205B8F0-B787-445E-B290-8CB56C1B9068

Q34048086-6F79872A-0319-465B-B4B5-4478F21E2CA1

P304

Q34048086-32EC280F-C8C7-453B-9938-FD24C2D30E70

P31

Q34048086-3BD62044-E8C3-4CFE-B76A-D2BF7A815549

P356

Q34048086-4CEFD6F4-17C0-498D-A460-4AE8F0C95DFB

P407

Q34048086-6C2BBB42-7A65-4F6B-8EE7-E6F27ADA0CEE

P433

Q34048086-1E70AB0D-914F-48DE-858B-0A731195CE45

P478

Q34048086-FA418270-43E3-4C4C-8BC2-393F2D1B288C

P50

Q34048086-A10021F2-5809-41CD-AC1E-91DE3878F5FE

Q34048086-A5F815DD-1963-4843-9A5F-15C22835BC18

Q34048086-B7C0B0A8-1560-4E7F-867A-6AC3F32F50C3

Q34048086-CCC2261C-D667-4233-A8B3-8A7833268FB4

Q34048086-F00A24F1-5559-4A0A-BA6E-749F926038A6

Q34048086-FBC1A917-9BFF-4393-B477-46B7BB1CC49B

P577

Q34048086-5CF04119-C50F-47CD-9278-EDF24CE699D1

P5875

Q34048086-E4457AE1-0392-411F-B08C-BF7CF623BCD0

P698

Q34048086-4689342C-14FA-4871-B280-DB7E10FC23E9

P932

Q34048086-474CEDCA-984C-41C1-BDC9-6F67808C47D3

P356

PNAS.0504613102

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Engineering stable peptide tox ...... ion of the alpha-conotoxin MII

@en

P2093

Harald Fischer

http://www.w3.org/2001/XMLSchema#string

Louise Dempster

http://www.w3.org/2001/XMLSchema#string

Simon T Nevin

http://www.w3.org/2001/XMLSchema#string

P2860

The Protein Data Bank

PROMOTIF--a program to identify and analyze structural motifs in proteins

Plant cyclotides: A unique family of cyclic and knotted proteins that defines the cyclic cystine knot structural motif

Twists, knots, and rings in proteins. Structural definition of the cyclotide framework

A new alpha-conotoxin which targets alpha3beta2 nicotinic acetylcholine receptors

Three-dimensional solution structure of alpha-conotoxin MII by NMR spectroscopy: effects of solution environment on helicity

AQUA and PROCHECK-NMR: programs for checking the quality of protein structures solved by NMR

Torsion angle dynamics for NMR structure calculation with the new program DYANA

Squash inhibitors: from structural motifs to macrocyclic knottins

1H, 13C and 15N random coil NMR chemical shifts of the common amino acids. I. Investigations of nearest-neighbor effects

P304

13767-13772

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1073/PNAS.0504613102

http://www.w3.org/2001/XMLSchema#string

P407

P433

39

http://www.w3.org/2001/XMLSchema#string

P478

102

http://www.w3.org/2001/XMLSchema#string

P50

Richard J. Clark

Frederic A Meunier

K. Johan Rosengren

P577

2005-09-14T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

7599691

http://www.w3.org/2001/XMLSchema#string

P698

16162671

http://www.w3.org/2001/XMLSchema#string

P932

1236553

http://www.w3.org/2001/XMLSchema#string