Characterization of the common genetic defect in humans deficient in debrisoquine metabolism.
about
Risk assessment and communication tools for genotype associations with multifactorial phenotypes: the concept of "edge effect" and cultivating an ethical bridge between omics innovations and societyExpression and alternative splicing of the cytochrome P-450 CYP2A7Expression and functional analysis of CYP2D6.24, CYP2D6.26, CYP2D6.27, and CYP2D7 isozymesPharmacogenetics and pharmacogenomicsAlternative splicing in the human cytochrome P450IIB6 gene generates a high level of aberrant messagesPharmacogenomics in the clinicImpact of New Genomic Technologies on Understanding Adverse Drug ReactionsAnti-LKM-1 antibodies determined by use of recombinant P450 2D6 in ELISA and western blot and their association with anti-HCV and HCV-RNAGenomic cloning and protein expression of a novel rat brain cytochrome P-450 CYP2D18* catalyzing imipramine N-demethylationPharmacogenetics: detecting sensitive populationsSusceptibility to human cancer: From the perspective of a pathologist.Contributions of human enzymes in carcinogen metabolismLong-Read Single Molecule Real-Time Full Gene Sequencing of Cytochrome P450-2D6.Pharmacogenetics: data, concepts and tools to improve drug discovery and drug treatment.Inhibition and possible induction of rat CYP2D after short- and long-term treatment with antidepressants.Deletion of the entire cytochrome P450 CYP2D6 gene as a cause of impaired drug metabolism in poor metabolizers of the debrisoquine/sparteine polymorphismGenetic polymorphisms of human N-acetyltransferase, cytochrome P450, glutathione-S-transferase, and epoxide hydrolase enzymes: relevance to xenobiotic metabolism and toxicity.Oxidative polymorphism of debrisoquine in Parkinson's diseaseTwo mutant alleles of the human cytochrome P-450db1 gene (P450C2D1) associated with genetically deficient metabolism of debrisoquine and other drugsAberrant splicing and missense mutations cause steroid 21-hydroxylase [P-450(C21)] deficiency in humans: possible gene conversion products.Antibodies against human cytochrome P-450db1 in autoimmune hepatitis type II.Molecular analysis and modeling of inactivation of human CYP2D6 by four mechanism based inactivators.A urine metabolic ratio of dextromethorphan and 3-methoxymorphinan as a probe for CYP3A activity and prediction of cyclosporine clearance in healthy volunteers.Genetic basis for a lower prevalence of deficient CYP2D6 oxidative drug metabolism phenotypes in black Americans.Pharmacogenomics: the genomics of drug response.Furafylline is a potent and selective inhibitor of cytochrome P450IA2 in man.Genetic variants in the metabolism of omega-6 and omega-3 fatty acids: their role in the determination of nutritional requirements and chronic disease risk.Regional and cellular expression of CYP2D6 in human brain: higher levels in alcoholics.Pharmacogenetic diagnostics of cytochrome P450 polymorphisms in clinical drug development and in drug treatment.Pharmacogenomics to predict drug response.LKM-1 autoantibodies recognize a short linear sequence in P450IID6, a cytochrome P-450 monooxygenase.Acetylation pharmacogenetics. The slow acetylator phenotype is caused by decreased or absent arylamine N-acetyltransferase in human liverPolymorphic cytochrome P450 2D6: humanized mouse model and endogenous substrates.Functional genomics of membrane transporters in human populations.Metabolism of theophylline by cDNA-expressed human cytochromes P-450.Cytochrome P4502D6 genotype does not determine response to clozapine.An unequal cross-over event within the CYP2D gene cluster generates a chimeric CYP2D7/CYP2D6 gene which is associated with the poor metabolizer phenotypeLack of a relationship between the polymorphism of debrisoquine oxidation and lung cancerDifferential foetal development of the O- and N-demethylation of codeine and dextromethorphan in manA screening test for slow metabolisers of tolbutamide.
P2860
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P2860
Characterization of the common genetic defect in humans deficient in debrisoquine metabolism.
description
1988 nî lūn-bûn
@nan
1988 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
1988 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
1988年の論文
@ja
1988年論文
@yue
1988年論文
@zh-hant
1988年論文
@zh-hk
1988年論文
@zh-mo
1988年論文
@zh-tw
1988年论文
@wuu
name
Characterization of the common ...... nt in debrisoquine metabolism.
@ast
Characterization of the common ...... nt in debrisoquine metabolism.
@en
Characterization of the common ...... nt in debrisoquine metabolism.
@nl
type
label
Characterization of the common ...... nt in debrisoquine metabolism.
@ast
Characterization of the common ...... nt in debrisoquine metabolism.
@en
Characterization of the common ...... nt in debrisoquine metabolism.
@nl
prefLabel
Characterization of the common ...... nt in debrisoquine metabolism.
@ast
Characterization of the common ...... nt in debrisoquine metabolism.
@en
Characterization of the common ...... nt in debrisoquine metabolism.
@nl
P2093
P356
P1433
P1476
Characterization of the common ...... nt in debrisoquine metabolism.
@en
P2093
Gelboin HV
Gonzalez FJ
Hardwick JP
P2888
P304
P356
10.1038/331442A0
P407
P577
1988-02-01T00:00:00Z
P6179
1032224836