A type-II kinase inhibitor capable of inhibiting the T315I "gatekeeper" mutant of Bcr-Abl.

A type-II kinase inhibitor capable of inhibiting the T315I "gatekeeper" mutant of Bcr-Abl.

Item
http://www.wikidata.org/entity/Q34052015
Mechanisms of drug resistance in kinases.Overcoming Bcr-Abl T315I mutation by combination of GNF-2 and ATP competitors in an Abl-independent mechanism.Identification of novel therapeutic targets in acute leukemias with NRAS mutations using a pharmacologic approachThe Effect of Mutations on Drug Sensitivity and Kinase Activity of Fibroblast Growth Factor Receptors: A Combined Experimental and Theoretical Study.Molecular mechanisms of drug resistance in tyrosine kinases cAbl and cKit.Combination therapy with nilotinib for drug-sensitive and drug-resistant BCR-ABL-positive leukemia and other malignancies.Opening the door to the development of novel Abl kinase inhibitors.Molecular modeling study of the induced-fit effect on kinase inhibition: the case of fibroblast growth factor receptor 3 (FGFR3).Development of 'DFG-out' inhibitors of gatekeeper mutant kinases.An amino-indazole scaffold with spectrum selective kinase inhibition of FLT3, PDGFRα and kit.Quantitative, Wide-Spectrum Kinase Profiling in Live Cells for Assessing the Effect of Cellular ATP on Target Engagement.Synthesis and identification of GZD856 as an orally bioavailable Bcr-AblT315I inhibitor overcoming acquired imatinib resistance.Identification of common inhibitors of wild-type and T315I mutant of BCR-ABL through the parallel structure-based virtual screening.
P2860

A type-II kinase inhibitor capable of inhibiting the T315I "gatekeeper" mutant of Bcr-Abl.

Item
http://www.wikidata.org/entity/Q34052015
description
2010 nî lūn-bûn
@nan
2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
name
A type-II kinase inhibitor cap ...... gatekeeper" mutant of Bcr-Abl.
@ast
A type-II kinase inhibitor cap ...... gatekeeper" mutant of Bcr-Abl.
@en
A type-II kinase inhibitor cap ...... gatekeeper" mutant of Bcr-Abl.
@nl
type
label
A type-II kinase inhibitor cap ...... gatekeeper" mutant of Bcr-Abl.
@ast
A type-II kinase inhibitor cap ...... gatekeeper" mutant of Bcr-Abl.
@en
A type-II kinase inhibitor cap ...... gatekeeper" mutant of Bcr-Abl.
@nl
prefLabel
A type-II kinase inhibitor cap ...... gatekeeper" mutant of Bcr-Abl.
@ast
A type-II kinase inhibitor cap ...... gatekeeper" mutant of Bcr-Abl.
@en
A type-II kinase inhibitor cap ...... gatekeeper" mutant of Bcr-Abl.
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P698
P932
P356
P1433
P1476
A type-II kinase inhibitor cap ...... gatekeeper" mutant of Bcr-Abl.
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P698
P932