Interleukin-7 receptor signaling is deficient in CD4+ T cells from HIV-infected persons and is inversely associated with aging. - Wikidata - awgldk - TriplyDB

Interleukin-7 receptor signaling is deficient in CD4+ T cells from HIV-infected persons and is inversely associated with aging.

Interleukin-7 receptor signaling is deficient in CD4+ T cells from HIV-infected persons and is inversely associated with aging.

http://www.wikidata.org/entity/Q34052036

about

Cycling memory CD4+ T cells in HIV disease have a diverse T cell receptor repertoire and a phenotype consistent with bystander activation.Increased bone marrow interleukin-7 (IL-7)/IL-7R levels but reduced IL-7 responsiveness in HIV-positive patients lacking CD4+ gain on antiviral therapy Aberrant plasma IL-7 and soluble IL-7 receptor levels indicate impaired T-cell response to IL-7 in human tuberculosis.Inflammatory cytokines drive CD4+ T-cell cycling and impaired responsiveness to interleukin 7: implications for immune failure in HIV disease.Decreased IL-7 responsiveness is related to oxidative stress in HIV disease.A challenge for the future: aging and HIV infection.Immunologic failure despite suppressive antiretroviral therapy is related to activation and turnover of memory CD4 cells Interferon-α inhibits CD4 T cell responses to interleukin-7 and interleukin-2 and selectively interferes with Akt signaling.Suboptimal immune reconstitution in vertically HIV infected children: a view on how HIV replication and timing of HAART initiation can impact on T and B-cell compartment Generalized Liver- and Blood-Derived CD8+ T-Cell Impairment in Response to Cytokines in Chronic Hepatitis C Virus Infection Compartment-specific distribution of human intestinal innate lymphoid cells is altered in HIV patients under effective therapy.HIV-Tat regulates macrophage gene expression in the context of neuroAIDS.Efforts of the human immune system to maintain the peripheral CD8+ T cell compartment after childhood thymectomy Kynurenine Reduces Memory CD4 T-Cell Survival by Interfering with Interleukin-2 Signaling Early during HIV-1 Infection.Recycled IL-7 Can Be Delivered to Neighboring T Cells.When Aging Reaches CD4+ T-Cells: Phenotypic and Functional Changes.Molecular mechanisms involved in the aging of the T-cell immune response.Dual mechanism of impairment of interleukin-7 (IL-7) responses in human immunodeficiency virus infection: decreased IL-7 binding and abnormal activation of the JAK/STAT5 pathway.Frequencies of FoxP3+ naive T cells are related to both viral load and naive T cell proliferation responses in HIV disease.Interleukin-7 enhances memory CD8(+) T-cell recall responses in health but its activity is impaired in human immunodeficiency virus infection.Microparticle delivery of Interleukin-7 to boost T-cell proliferation and survival.

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P2860

Interleukin-7 receptor signaling is deficient in CD4+ T cells from HIV-infected persons and is inversely associated with aging.

http://www.wikidata.org/entity/Q34052036

description

2009 nî lūn-bûn

@nan

2009 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի ապրիլին հրատարակված գիտական հոդված

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2009年の論文

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年學術文章

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Interleukin-7 receptor signali ...... versely associated with aging.

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Interleukin-7 receptor signali ...... versely associated with aging.

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The Journal of Infectious Diseases

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Interleukin-7 receptor signali ...... versely associated with aging.

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P2093

Douglas A Bazdar

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Magdalena Kalinowska

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Scott F Sieg

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P2860

CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract

Increased production of IL-7 accompanies HIV-1-mediated T-cell depletion: implications for T-cell homeostasis

Bcl-2 can rescue T lymphocyte development in interleukin-7 receptor-deficient mice but not in mutant rag-1-/- mice

Gastrointestinal tract as a major site of CD4+ T cell depletion and viral replication in SIV infection

Defective thymocyte development and perturbed homeostasis of T cells in STAT-induced STAT inhibitor-1/suppressors of cytokine signaling-1 transgenic mice.

Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo.

CD8 naive T cell counts decrease progressively in HIV-infected adults

Stat5a/b are essential for normal lymphoid development and differentiation.

Naïve T-cell dynamics in human immunodeficiency virus type 1 infection: effects of highly active antiretroviral therapy provide insights into the mechanisms of naive T-cell depletion.

Naive T-cell depletion related to infection by X4 human immunodeficiency virus type 1 in poor immunological responders to highly active antiretroviral therapy.

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1019-1028

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10.1086/597210

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