The synthesis of novel GABA uptake inhibitors. 1. Elucidation of the structure-activity studies leading to the choice of (R)-1-[4,4-bis(3-methyl-2-thienyl)-3-butenyl]-3-piperidinecarboxylic acid (tiagabine) as an anticonvulsant drug candidate.
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An overview of the synthetic routes to the best selling drugs containing 6-membered heterocyclesgamma-Aminobutyric acid transporters in the cat periaqueductal gray: a light and electron microscopic immunocytochemical study.Basic mechanisms of gabitril (tiagabine) and future potential developments.Development and validation of an LC-ESI-MS/MS quantification method for a potential γ-aminobutyric acid transporter 3 (GAT3) marker and its application in preliminary MS binding assays.Generation and screening of oxime libraries addressing the neuronal GABA transporter GAT1.GABA transporters as targets for new drugs.Muscimol as an ionotropic GABA receptor agonist.Synergistic interaction of gabapentin with tiagabine in the formalin test in mice: an isobolographic analysis.Different Binding Modes of Small and Large Binders of GAT1.A review of the preclinical pharmacology of tiagabine: a potent and selective anticonvulsant GABA uptake inhibitor.Clobazam, oxcarbazepine, tiagabine, topiramate, and other new antiepileptic drugs.A binding mode hypothesis of tiagabine confirms liothyronine effect on γ-aminobutyric acid transporter 1 (GAT1)Molecular targets for the rational design of antiepileptic drugs and related neuroprotective agents.Conformationally Restricted GABA with Bicyclo[3.1.0]hexane Backbone as the First Highly Selective BGT-1 Inhibitor.Classification of High-Activity Tiagabine Analogs by Binary QSAR Modeling.Stereoselective central nervous system effects of the R- and S-isomers of the GABA uptake blocker N-(4, 4-di-(3-methylthien-2-yl)but-3-enyl) nipecotic acid in the rat.Tiagabine: efficacy and safety in adjunctive treatment of partial seizures.Epileptiform activity triggers long-term plasticity of GABA(B) receptor signalling in the developing rat hippocampus.Cobalt-Catalyzed 1,1-Diboration of Terminal Alkynes: Scope, Mechanism, and Synthetic Applications.Pairwise structural comparison of tiagabine analogs gives new insights into their protein binding modes.New Hydrazides and Thiosemicarbazides Derived from Ethylenedioxythiophene as Potential Anticonvulsants
P2860
Q28301501-3C40A310-C331-4D8E-AF62-BF67E647DA11Q31696708-C40BB7C6-4C1E-4580-8DD3-C22DC5E22FD3Q33804496-AF51FFBB-475B-4AD8-A89F-B176DB55774BQ34504715-059D4F97-7BE4-4AB9-9672-8AF0746B1487Q35393157-09E03FCE-8D27-4C0E-B557-9781943982BCQ37856289-3C9D716D-1FA9-4F06-971D-BE01F92EB57BQ38182857-9385456D-F89C-4EF1-8E4D-CF4D94D5613BQ39314422-84737996-5F44-4EB1-8CBB-3DCA176AED6CQ40068020-4BDCE86C-AB35-4948-B001-503ECE3C1249Q40412354-03909952-BC4D-4AE9-BBCD-8E4F72F454DAQ41093072-4C832010-D9FA-4FA1-8D2C-92F2533F3BCCQ41439937-FA4F9BB1-B43C-4209-B9DD-B4D10393F2E8Q41634637-03E4EDCF-669E-4E23-B46B-CE75D9D6D31CQ41817527-67BA26EC-CE35-4482-8DD2-71C3EB38790BQ41890150-0C976C91-E0A2-4FC9-959F-5E9DE0760AACQ41977092-A6679296-7CFE-4C60-878B-16A929E40440Q43664151-F928D64A-7F40-47CB-B78D-D2D98FAA7393Q46646817-3955D908-12FA-4DDF-97E1-56CBB6734707Q48234511-0EC13762-AB8A-4758-90C8-2561CB266620Q55665570-909D3534-AA9E-4188-991A-A0C8E4FDD019Q57714581-28D2B44A-8C4D-4CCD-9396-2A958E37CE55
P2860
The synthesis of novel GABA uptake inhibitors. 1. Elucidation of the structure-activity studies leading to the choice of (R)-1-[4,4-bis(3-methyl-2-thienyl)-3-butenyl]-3-piperidinecarboxylic acid (tiagabine) as an anticonvulsant drug candidate.
description
1993 nî lūn-bûn
@nan
1993 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
name
The synthesis of novel GABA up ...... anticonvulsant drug candidate.
@ast
The synthesis of novel GABA up ...... anticonvulsant drug candidate.
@en
The synthesis of novel GABA up ...... anticonvulsant drug candidate.
@nl
type
label
The synthesis of novel GABA up ...... anticonvulsant drug candidate.
@ast
The synthesis of novel GABA up ...... anticonvulsant drug candidate.
@en
The synthesis of novel GABA up ...... anticonvulsant drug candidate.
@nl
prefLabel
The synthesis of novel GABA up ...... anticonvulsant drug candidate.
@ast
The synthesis of novel GABA up ...... anticonvulsant drug candidate.
@en
The synthesis of novel GABA up ...... anticonvulsant drug candidate.
@nl
P2093
P356
P1476
The synthesis of novel GABA up ...... anticonvulsant drug candidate.
@en
P2093
A S Jørgensen
C Braestrup
E B Nielsen
F C Grønwald
K E Andersen
L J Knutsen
P D Suzdak
P O Sørensen
U Sonnewald
P304
P356
10.1021/JM00064A005
P407
P577
1993-06-01T00:00:00Z