The lethal and edema factors of anthrax toxin bind only to oligomeric forms of the protective antigen
about
A model of anthrax toxin lethal factor bound to protective antigen.Binary bacterial toxins: biochemistry, biology, and applications of common Clostridium and Bacillus proteinsCrystal structure of the von Willebrand factor A domain of human capillary morphogenesis protein 2: an anthrax toxin receptorHuman monoclonal antibodies against anthrax lethal factor and protective antigen act independently to protect against Bacillus anthracis infection and enhance endogenous immunity to anthraxLethal factor of anthrax toxin binds monomeric form of protective antigenAnthrax lethal toxin-mediated killing of human and murine dendritic cells impairs the adaptive immune responseTumor Targeting and Drug Delivery by Anthrax ToxinRoles of Anthrax Toxin Receptor 2 in Anthrax Toxin Membrane Insertion and Pore FormationAnthrax Toxins in Context of Bacillus anthracis Spores and Spore GerminationBacillus anthracis edema factor substrate specificity: evidence for new modes of actionCellular and physiological effects of anthrax exotoxin and its relevance to disease.Toxin-based therapeutic approachespH effects on binding between the anthrax protective antigen and the host cellular receptor CMG2Crystal structure of BinB: a receptor binding component of the binary toxin from Lysinibacillus sphaericusLethal and edema toxins in the pathogenesis of Bacillus anthracis septic shock: implications for therapyA high-affinity monoclonal antibody to anthrax protective antigen passively protects rabbits before and after aerosolized Bacillus anthracis spore challengeThe Disulfide Bond Cys255-Cys279 in the Immunoglobulin-Like Domain of Anthrax Toxin Receptor 2 Is Required for Membrane Insertion of Anthrax Protective Antigen PoreA protective antigen mutation increases the pH threshold of anthrax toxin receptor 2-mediated pore formationSolubilization and characterization of the anthrax toxin pore in detergent micellesMembrane insertion by anthrax protective antigen in cultured cells.Anthrax: a continuing concern in the era of bioterrorism.Comparison of the structural stability and dynamic properties of recombinant anthrax protective antigen and its 2-fluorohistidine-labeled analogue.Effects of spontaneous deamidation on the cytotoxic activity of the Bacillus anthracis protective antigen.Selection and characterization of human antibodies neutralizing Bacillus anthracis toxin.Inhibition of anthrax lethal toxin-induced cytolysis of RAW264.7 cells by celastrol.Anthrax prevention and treatment: utility of therapy combining antibiotic plus vaccine.Disulfide bonds in the ectodomain of anthrax toxin receptor 2 are required for the receptor-bound protective-antigen pore to function.Mapping dominant-negative mutations of anthrax protective antigen by scanning mutagenesis.Targeting Bacillus anthracis toxicity with a genetically selected inhibitor of the PA/CMG2 protein-protein interactionEfficient targeting of head and neck squamous cell carcinoma by systemic administration of a dual uPA and MMP-activated engineered anthrax toxin.Tumor endothelium marker-8 based decoys exhibit superiority over capillary morphogenesis protein-2 based decoys as anthrax toxin inhibitors.Inter-alpha-inhibitor proteins are endogenous furin inhibitors and provide protection against experimental anthrax intoxication.Comparative toxicity and efficacy of engineered anthrax lethal toxin variants with broad anti-tumor activitiesMapping the lethal factor and edema factor binding sites on oligomeric anthrax protective antigen.Nano aptasensor for protective antigen toxin of anthrax.Direct inhibition of T-lymphocyte activation by anthrax toxins in vivo.Vaccination of rhesus macaques with the anthrax vaccine adsorbed vaccine produces a serum antibody response that effectively neutralizes receptor-bound protective antigen in vitro.A chimeric protein that functions as both an anthrax dual-target antitoxin and a trivalent vaccine.A FRET-based high throughput screening assay to identify inhibitors of anthrax protective antigen binding to capillary morphogenesis gene 2 proteinStructural and immunological analysis of anthrax recombinant protective antigen adsorbed to aluminum hydroxide adjuvant.
P2860
Q24537617-1DF545E1-58B5-49D7-8D35-E9DB79F1DF8FQ24562788-F13CB611-E366-4C81-BFB5-3822DA724FDDQ24564886-391A014C-0DB6-427C-B501-E65D437F1E30Q24682011-308AA159-5ADB-4578-9E7D-E76975D3EE32Q24682713-E8EED394-4328-4938-956E-1224D0F6C14BQ24816298-97E0FB7D-CE94-4DB9-8A7B-B6804440BAAFQ26744720-D030D578-0F29-4062-AA26-6230575E1CF5Q26775093-B9658451-4DE5-432C-B583-A9BC7A38CE12Q26796601-290D949A-A1CB-45F4-B05F-A521DAA0D977Q27000357-ACE79C0E-466F-4E38-95CF-D8DD00F9AE91Q27010363-764313EB-5744-4E14-9C73-5BB4BC0E0D02Q27013664-89FEA640-6C7A-46CE-AB4C-E41E576DBBCEQ27671060-7C467DC0-3866-4AE0-8D2D-C43787527B29Q27690806-2514B392-143E-4569-8B9B-E309D57211C0Q28383094-296EBFD1-3D1A-4531-9513-4952FE96A60FQ28398021-1D5C5E90-6FCE-485D-A8FD-4C8BBDB15563Q28548647-E9C3D833-9079-452A-8A10-6A4A80AA51EEQ30153424-FAEC3341-340A-4235-AE04-6745FB246871Q30157192-5097EBFF-E8B7-4C66-B91B-72A33F757D4EQ30160208-876FA7AB-9612-4CD1-AF8C-7E871F87FF67Q30232983-F5C5C84D-0B47-40D2-8726-5482C166DE98Q30551104-D10ADA04-7E6F-418B-A9CA-1F243AC27046Q33224077-FBE14C84-228C-43A9-BCBD-20F5E29BD589Q33306246-784E5D4A-83E9-4FC5-9C8E-85D22CD3DDB6Q33313876-E9B40A30-875A-43B9-953C-BA427095E2B8Q33505445-7F5D2A94-7F0D-42DB-9D18-B046D7027A71Q33580226-226C80F9-FD2B-46AA-9936-47BB635D8ACAQ33713102-2B9CC883-247C-4721-AB32-9DD10AE10D4EQ33780004-6170FBF4-5FE5-4DBC-891D-9047B211C2C4Q33927058-F2396319-BAA2-4E99-8A52-95C174BC43C7Q33933081-9DE55035-BF6A-4822-95F4-59EBABA5ECA4Q33946836-F2358244-40F4-49FF-8E20-156E69C39B04Q34063766-AF90139C-7E2C-495E-B442-65730FAEF4ADQ34068323-12C7ABC9-1FF5-467A-97B5-C1A63B1E1060Q34095583-AE4BB54C-B289-4902-B757-313C0354A3E6Q34194649-9B89AC43-0B94-4DC9-8B2A-EE3CBE940A81Q34289924-BC23702F-BC3B-479E-9AB0-9F18ED021220Q34289944-79E681BF-8C45-48A7-990B-E4067EA618B1Q34328401-A5A73D43-6B39-481E-B759-E45448C9605EQ34344419-8E78AED5-D709-4916-A77C-9DFEC905ACFB
P2860
The lethal and edema factors of anthrax toxin bind only to oligomeric forms of the protective antigen
description
2002 nî lūn-bûn
@nan
2002 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
The lethal and edema factors o ...... orms of the protective antigen
@ast
The lethal and edema factors o ...... orms of the protective antigen
@en
The lethal and edema factors o ...... orms of the protective antigen
@nl
type
label
The lethal and edema factors o ...... orms of the protective antigen
@ast
The lethal and edema factors o ...... orms of the protective antigen
@en
The lethal and edema factors o ...... orms of the protective antigen
@nl
prefLabel
The lethal and edema factors o ...... orms of the protective antigen
@ast
The lethal and edema factors o ...... orms of the protective antigen
@en
The lethal and edema factors o ...... orms of the protective antigen
@nl
P2093
P2860
P356
P1476
The lethal and edema factors o ...... orms of the protective antigen
@en
P2093
D Borden Lacy
Jeremy Mogridge
Kristina Cunningham
Michael Mourez
P2860
P304
P356
10.1073/PNAS.052160199
P407
P577
2002-05-07T00:00:00Z