Genome-wide identification of PAX3-FKHR binding sites in rhabdomyosarcoma reveals candidate target genes important for development and cancer. - Wikidata - awgldk - TriplyDB

Genome-wide identification of PAX3-FKHR binding sites in rhabdomyosarcoma reveals candidate target genes important for development and cancer.

Genome-wide identification of PAX3-FKHR binding sites in rhabdomyosarcoma reveals candidate target genes important for development and cancer.

http://www.wikidata.org/entity/Q34069048

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Mechanisms of impaired differentiation in rhabdomyosarcoma Cell-cycle dependent expression of a translocation-mediated fusion oncogene mediates checkpoint adaptation in rhabdomyosarcoma Cell-based small-molecule compound screen identifies fenretinide as potential therapeutic for translocation-positive rhabdomyosarcoma Six homeoproteins directly activate Myod expression in the gene regulatory networks that control early myogenesis Understanding the Interplay between Expression, Mutation and Activity of ALK Receptor in Rhabdomyosarcoma Cells for Clinical Application of Small-Molecule Inhibitors Fusion transcriptome profiling provides insights into alveolar rhabdomyosarcoma.Aberrant CDK4 amplification in refractory rhabdomyosarcoma as identified by genomic profiling Large-scale quality analysis of published ChIP-seq data.Insulin growth factor-receptor (IGF-1R) antibody cixutumumab combined with the mTOR inhibitor temsirolimus in patients with refractory Ewing's sarcoma family tumors.Hyper-activation of Notch3 amplifies the proliferative potential of rhabdomyosarcoma cells.PDGFRβ reverses EphB4 signaling in alveolar rhabdomyosarcoma.Therapeutic potential of TAS-115 via c-MET and PDGFRα signal inhibition for synovial sarcoma.Is fibroblast growth factor receptor 4 a suitable target of cancer therapy?Pediatric Rhabdomyosarcoma.Carnitine palmitoyltransferase 1A (CPT1A): a transcriptional target of PAX3-FKHR and mediates PAX3-FKHR-dependent motility in alveolar rhabdomyosarcoma cells Genome-wide recruitment to Polycomb-modified chromatin and activity regulation of the synovial sarcoma oncogene SYT-SSX2.Recurrent PAX3-MAML3 fusion in biphenotypic sinonasal sarcoma.A recurrent neomorphic mutation in MYOD1 defines a clinically aggressive subset of embryonal rhabdomyosarcoma associated with PI3K-AKT pathway mutations.Cyclin-dependent kinase 4 phosphorylates and positively regulates PAX3-FOXO1 in human alveolar rhabdomyosarcoma cells Itm2a is a Pax3 target gene, expressed at sites of skeletal muscle formation in vivo.Drozitumab, a human antibody to death receptor 5, has potent antitumor activity against rhabdomyosarcoma with the expression of caspase-8 predictive of response.Targeting wild-type and mutationally activated FGFR4 in rhabdomyosarcoma with the inhibitor ponatinib (AP24534).A rapid one-generation genetic screen in a Drosophila model to capture rhabdomyosarcoma effectors and therapeutic targets Comprehensive genomic analysis of rhabdomyosarcoma reveals a landscape of alterations affecting a common genetic axis in fusion-positive and fusion-negative tumors.New Treatments for Rhabdomyosarcoma: the Importance of Target Practice Childhood rhabdomyosarcoma: recent advances and prospective views.AKT and PAX3-FKHR cooperation enforces myogenic differentiation blockade in alveolar rhabdomyosarcoma cell Advances in sarcoma genomics and new therapeutic targets.The Proprotein Convertase Furin Contributes to Rhabdomyosarcoma Malignancy by Promoting Vascularization, Migration and Invasion.Potent inhibition of angiogenesis by the IGF-1 receptor-targeting antibody SCH717454 is reversed by IGF-2.Alveolar rhabdomyosarcoma - The molecular drivers of PAX3/7-FOXO1-induced tumorigenesis Secreted Frizzled-Related Protein 3 (SFRP3) Is Required for Tumorigenesis of PAX3-FOXO1-Positive Alveolar Rhabdomyosarcoma Biologic and clinical characteristics of adolescent and young adult cancers: Acute lymphoblastic leukemia, colorectal cancer, breast cancer, melanoma, and sarcoma Zebrafish rhabdomyosarcoma reflects the developmental stage of oncogene expression during myogenesis.FGFR4 blockade exerts distinct antitumorigenic effects in human embryonal versus alveolar rhabdomyosarcoma.Anti-ALK Antibodies in Patients with ALK-Positive Malignancies Not Expressing NPM-ALK.Comparative transcriptomic analysis reveals the oncogenic fusion protein PAX3-FOXO1 globally alters mRNA and miRNA to enhance myoblast invasion.Expression of FGFR3 and FGFR4 and clinical risk factors associated with progression-free survival in synovial sarcoma Small molecule inhibition of PAX3-FOXO1 through AKT activation suppresses malignant phenotypes of alveolar rhabdomyosarcoma PAX3-FKHR regulates the expression of pleiotrophin to mediate motility in alveolar rhabdomyosarcoma cells.

P2860

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Genome-wide identification of PAX3-FKHR binding sites in rhabdomyosarcoma reveals candidate target genes important for development and cancer.

http://www.wikidata.org/entity/Q34069048

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2010 nî lūn-bûn

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2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2010 թվականի հուլիսին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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Cancer Research

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Genome-wide identification of ...... nt for development and cancer.

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David O Azorsa

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Fan Yang

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Lee J Helman

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Liang Cao

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Linnia H Mayeenuddin

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Marbin Pineda

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Paul S Meltzer

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Robert L Walker

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Sven Bilke

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Yunkai Yu

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P2860

Identification of target genes regulated by PAX3 and PAX3-FKHR in embryogenesis and alveolar rhabdomyosarcoma

The PAX3-FKHR fusion protein created by the t(2;13) translocation in alveolar rhabdomyosarcomas is a more potent transcriptional activator than PAX3

MyoD and the regulation of myogenesis by helix-loop-helix proteins

Identification of ALK as a major familial neuroblastoma predisposition gene

Activating mutations in ALK provide a therapeutic target in neuroblastoma.

PAX3-FKHR and PAX7-FKHR gene fusions are prognostic indicators in alveolar rhabdomyosarcoma: a report from the children's oncology group

Identification of PAX3-FKHR-regulated genes differentially expressed between alveolar and embryonal rhabdomyosarcoma: focus on MYCN as a biologically relevant target

Cell-type-specific regulation of distinct sets of gene targets by Pax3 and Pax3/FKHR

Mox2 is a component of the genetic hierarchy controlling limb muscle development

The paired-like homeo box gene MHox is required for early events of skeletogenesis in multiple lineages

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