Leptin as a novel profibrogenic cytokine in hepatic stellate cells: mitogenesis and inhibition of apoptosis mediated by extracellular regulated kinase (Erk) and Akt phosphorylation.
about
Exendin-4, a glucagon-like protein-1 (GLP-1) receptor agonist, reverses hepatic steatosis in ob/ob miceThe Effects of Leptin Replacement on Neural PlasticityExtracellular matrix and liver diseaseCould metabolic syndrome lead to hepatocarcinoma via non-alcoholic fatty liver disease?leptin-induced growth stimulation of breast cancer cells involves recruitment of histone acetyltransferases and mediator complex to CYCLIN D1 promoter via activation of Stat3Adiponectin activation of AMPK disrupts leptin-mediated hepatic fibrosis via suppressors of cytokine signaling (SOCS-3)Adiponectin inhibits leptin signalling via multiple mechanisms to exert protective effects against hepatic fibrosisHepatic stellate cells: protean, multifunctional, and enigmatic cells of the liverAdiponectin antagonizes the oncogenic actions of leptin in hepatocellular carcinogenesis.A novel synthetic analog of 5, 8-disubstituted quinazolines blocks mitosis and induces apoptosis of tumor cells by inhibiting microtubule polymerization.Obesity and its metabolic complications: the role of adipokines and the relationship between obesity, inflammation, insulin resistance, dyslipidemia and nonalcoholic fatty liver disease.Loss of pericyte smoothened activity in mice with genetic deficiency of leptin.Involvement of DNA damage response pathways in hepatocellular carcinoma.Leptin is an anti-apoptotic effector in placental cells involving p53 downregulation.Concomitant activation of the JAK/STAT, PI3K/AKT, and ERK signaling is involved in leptin-mediated promotion of invasion and migration of hepatocellular carcinoma cellsLeptin increases tissue inhibitor of metalloproteinase I (TIMP-1) gene expression by a specificity protein 1/signal transducer and activator of transcription 3 mechanism.Adiponectin modulates C-jun N-terminal kinase and mammalian target of rapamycin and inhibits hepatocellular carcinoma.Leptin promotes the myofibroblastic phenotype in hepatic stellate cells by activating the hedgehog pathway.Leptin inhibits neutrophil apoptosis in children via ERK/NF-κB-dependent pathways.Treatment of non-alcoholic fatty liver disease.Upregulation of miR21 and repression of Grhl3 by leptin mediates sinusoidal endothelial injury in experimental nonalcoholic steatohepatitis.Leptin and fasting regulate rat gastric glucose-regulated protein 58.Leptin promotes fibroproliferative acute respiratory distress syndrome by inhibiting peroxisome proliferator-activated receptor-γPotential role of leptin, adiponectin and three novel adipokines--visfatin, chemerin and vaspin--in chronic hepatitis.Glp-1 analog, liraglutide, ameliorates hepatic steatosis and cardiac hypertrophy in C57BL/6J mice fed a Western diet.Serum Amyloid A Induces Inflammation, Proliferation and Cell Death in Activated Hepatic Stellate Cells.Adipose tissue and inflammatory bowel disease pathogenesisJAK-STAT pathway in carcinogenesis: is it relevant to cholangiocarcinoma progression?Cell signals influencing hepatic fibrosisLeptin regulates cyclin D1 in luminal epithelial cells of mouse MMTV-Wnt-1 mammary tumorsAdiponectin-derived active peptide ADP355 exerts anti-inflammatory and anti-fibrotic activities in thioacetamide-induced liver injuryOsteopontin is a proximal effector of leptin-mediated non-alcoholic steatohepatitis (NASH) fibrosis.Leptin's mitogenic effect in human liver cancer cells requires induction of both methionine adenosyltransferase 2A and 2betaLeptin induces phagocytosis of apoptotic bodies by hepatic stellate cells via a Rho guanosine triphosphatase-dependent mechanismLeptin neuroprotection in the CNS: mechanisms and therapeutic potentialsAdvances in antifibrotic therapy.Kupffer cells mediate leptin-induced liver fibrosisInsulin resistance and other metabolic risk factors in the pathogenesis of hepatocellular carcinoma.CYP2E1-dependent and leptin-mediated hepatic CD57 expression on CD8+ T cells aid progression of environment-linked nonalcoholic steatohepatitis.Plumbagin protects liver against fulminant hepatic failure and chronic liver fibrosis via inhibiting inflammation and collagen production.
P2860
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P2860
Leptin as a novel profibrogenic cytokine in hepatic stellate cells: mitogenesis and inhibition of apoptosis mediated by extracellular regulated kinase (Erk) and Akt phosphorylation.
description
2004 nî lūn-bûn
@nan
2004 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Leptin as a novel profibrogeni ...... (Erk) and Akt phosphorylation.
@ast
Leptin as a novel profibrogeni ...... (Erk) and Akt phosphorylation.
@en
Leptin as a novel profibrogeni ...... extracellular regulated kinase
@nl
type
label
Leptin as a novel profibrogeni ...... (Erk) and Akt phosphorylation.
@ast
Leptin as a novel profibrogeni ...... (Erk) and Akt phosphorylation.
@en
Leptin as a novel profibrogeni ...... extracellular regulated kinase
@nl
prefLabel
Leptin as a novel profibrogeni ...... (Erk) and Akt phosphorylation.
@ast
Leptin as a novel profibrogeni ...... (Erk) and Akt phosphorylation.
@en
Leptin as a novel profibrogeni ...... extracellular regulated kinase
@nl
P2093
P2860
P356
P1433
P1476
Leptin as a novel profibrogeni ...... (Erk) and Akt phosphorylation.
@en
P2093
Frank A Anania
Jeffrey Floyd
Mark A Titus
Neeraj K Saxena
Shanthi Srinivasan
Shanthi V Sitaraman
Xiaokun Ding
P2860
P304
P356
10.1096/FJ.04-1847FJE
P407
P577
2004-08-19T00:00:00Z