The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals. - Wikidata - awgldk - TriplyDB

The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals.

The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals.

http://www.wikidata.org/entity/Q34077795

about

Yap1 acts downstream of α-catenin to control epidermal proliferation Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling Mutant Gq/11 promote uveal melanoma tumorigenesis by activating YAP A tight junction-associated Merlin-angiomotin complex mediates Merlin's regulation of mitogenic signaling and tumor suppressive functions Merlin/NF2 loss-driven tumorigenesis linked to CRL4(DCAF1)-mediated inhibition of the hippo pathway kinases Lats1 and 2 in the nucleus Nf2-Yap signaling controls the expansion of DRG progenitors and glia during DRG development Spatial organization of Hippo signaling at the plasma membrane mediated by the tumor suppressor Merlin/NF2 Hippo signaling regulates microprocessor and links cell-density-dependent miRNA biogenesis to cancer Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP The hippo signaling pathway in development and cancer Environmental Ligands of the Aryl Hydrocarbon Receptor and Their Effects in Models of Adult Liver Progenitor Cells Mechanisms of Hippo pathway regulation Hepatocellular carcinoma mouse models: Hepatitis B virus-associated hepatocarcinogenesis and haploinsufficient tumor suppressor genes MST kinases in development and disease Evasion of anti-growth signaling: A key step in tumorigenesis and potential target for treatment and prophylaxis by natural compounds.Cross-talk between Wnt/β-catenin and Hippo signaling pathways: a brief review The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment Merlin Isoforms 1 and 2 Both Act as Tumour Suppressors and Are Required for Optimal Sperm Maturation Targeting Mechanotransduction at the Transcriptional Level: YAP and BRD4 Are Novel Therapeutic Targets for the Reversal of Liver Fibrosis Targeting the Hippo Signaling Pathway for Tissue Regeneration and Cancer Therapy Emerging Role of the Hippo Signaling Pathway in Position Sensing and Lineage Specification in Mammalian Preimplantation Embryos Emerging evidence on the role of the Hippo/YAP pathway in liver physiology and cancer Hippo/YAP pathway for targeted therapy Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer The Hippo effector Yorkie controls normal tissue growth by antagonizing scalloped-mediated default repression Tumor suppressor Nf2 limits expansion of the neural progenitor pool by inhibiting Yap/Taz transcriptional coactivators Ablation of Rassf2 induces bone defects and subsequent haematopoietic anomalies in mice Involvement of YAP, TAZ and HSP90 in contact guidance and intercellular junction formation in corneal epithelial cells The Hippo Pathway Targets Rae1 to Regulate Mitosis and Organ Size and to Feed Back to Regulate Upstream Components Merlin, Hippo, and Warts Mechanisms limiting body growth in mammals DLG5 connects cell polarity and Hippo signaling protein networks by linking PAR-1 with MST1/2 Regulation of localization and function of the transcriptional co-activator YAP by angiomotin.A novel mutation of the FAT2 gene in spinal meningioma.Tumor suppressor Nf2/merlin drives Schwann cell changes following electromagnetic field exposure through Hippo-dependent mechanisms.Yes-associated protein 1 is activated and functions as an oncogene in meningiomas.The Hippo signaling pathway and translational opportunities for brain cancers p75NTR is highly expressed in vestibular schwannomas and promotes cell survival by activating nuclear transcription factor κB.The Hippo signaling pathway in stem cell biology and cancer What do mechanotransduction, Hippo, Wnt, and TGFβ have in common? YAP and TAZ as key orchestrating molecules in ocular health and disease.The NF2 tumor suppressor, Merlin, regulates epidermal development through the establishment of a junctional polarity complex.

P2860

Q24294904-38BAFE24-AA8F-4709-A3E1-48669BCFADC0 Q24294906-83284316-3CA3-449A-BD5A-27B97664BD72 Q24298571-D29D0BFB-F892-4D0C-A513-5A7160E9838B Q24299493-3D68A1C1-AA13-425E-BCE2-D5D7D87AB594 Q24300770-7A5B2148-756B-4C7E-9945-6915F1B11742 Q24307540-BC1AB3F7-C8A9-4E08-ADBD-357C67892892 Q24323074-C1E193E7-6085-40DD-8127-C5A576DB51AF Q24338421-2CD5A9BB-4E79-42E5-A3CD-315F7133B272 Q24594281-D1F44D8A-2EBC-499A-A629-E17F1EA7A8FF Q24603986-F8A1F20D-741A-4093-8AF0-C37317486FD1 Q26747621-939EC991-E910-4696-AC1B-252B4B31D4FE Q26771285-F66D2984-FE33-422D-997C-E2C4818FAA8C Q26772317-92245595-F74E-4B2B-83F2-11F11A5A5DBA Q26787040-402FE47C-DD2B-406D-9AF1-92C1BC83B3BB Q26827810-11D464AD-B867-4646-9347-3C83A1E5F374 Q26851371-95BD67B6-CD8F-46D8-BEC5-EF009D70827F Q27025661-A450DDD6-17EC-4AF4-90F0-3A3DC9CA62B0 Q27304868-C93FE4A8-08EC-40DC-B6D0-5719F764DCD5 Q28070012-8A5E9CA9-D781-42FA-B16C-C6F70507F685 Q28078129-55CC7A75-9A15-4271-A198-3317A36601FD Q28083971-B2578821-3A5C-4D1D-851E-6B0F08249050 Q28086905-B38C9D08-89A0-4AAB-AAB9-1E3A8D8D0CAA Q28088294-34FF1981-9E6A-4618-9AC0-6341BCA5F8E0 Q28269498-29B6152E-E217-41EA-894C-AE79C2B87EFD Q28291847-5D5D64A8-17EE-4A85-A9F1-7D41E348A917 Q28504464-B63CD1FD-392A-4B7D-B3D5-558CDFBB0D86 Q28509403-5E75A285-33AD-431C-AEB2-E822D08081B8 Q28543584-D0AD627D-CEFA-4210-AE39-C5828BD9F397 Q28553403-B7822E03-8DBC-4456-BD59-8F755FA214BB Q28728958-C3BBF550-AC78-4E10-BEA2-DDA2AC8C6B65 Q29871129-E24E2840-6FA1-420B-98F5-C9FFF1B3BAAF Q30352874-162C1949-B1B4-4626-9B5B-FFB4FE40FAB6 Q30369056-5B7ECB23-6FFC-40CC-9346-AACAF9452FA6 Q30376040-CDFF8611-25C2-4B75-929C-EB97FD46404D Q30394387-F92C47B8-E8D2-477E-AEC5-196E60D80FDF Q30395225-9569A2D8-C1DF-45B3-81D9-975070208219 Q30401833-77F06D05-AB44-42CB-8263-697225CC93F1 Q30410176-6BE357CB-A874-4CA3-BEE9-6BE613A7762B Q30429628-FB2F23BA-5778-485D-BEEE-8A8A31973F67 Q30429717-4646367F-74B1-43EE-A789-181BCF2D8139

P2860

The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals.

http://www.wikidata.org/entity/Q34077795

description

2010 nî lūn-bûn

@nan

2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հուլիսին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年学术文章

@wuu

2010年学术文章

@zh-cn

2010年学术文章

@zh-hans

2010年学术文章

@zh-my

2010年学术文章

@zh-sg

2010年學術文章

@yue

name

The Merlin/NF2 tumor suppresso ...... tissue homeostasis in mammals.

@ast

The Merlin/NF2 tumor suppresso ...... tissue homeostasis in mammals.

@en

The Merlin/NF2 tumor suppresso ...... tissue homeostasis in mammals.

@nl

type

label

The Merlin/NF2 tumor suppresso ...... tissue homeostasis in mammals.

@ast

The Merlin/NF2 tumor suppresso ...... tissue homeostasis in mammals.

@en

The Merlin/NF2 tumor suppresso ...... tissue homeostasis in mammals.

@nl

prefLabel

The Merlin/NF2 tumor suppresso ...... tissue homeostasis in mammals.

@ast

The Merlin/NF2 tumor suppresso ...... tissue homeostasis in mammals.

@en

The Merlin/NF2 tumor suppresso ...... tissue homeostasis in mammals.

@nl

P1433

Q34077795-D419557D-DBA5-4110-91CD-5ACC71A9B0BB

P1476

Q34077795-10856CAD-3D70-4C0A-A860-ABF2DA109D1E

P2093

Q34077795-273C2726-0090-4257-A4EB-D331F80C348D

Q34077795-2BA856BE-91A6-4123-AAAF-CFBA2E6ABB92

Q34077795-42C1E727-9248-4853-B04A-2EBD9D060540

Q34077795-5443B9E7-8BCE-4DA4-B220-409C878E78D6

Q34077795-66B897E1-B895-4E14-B1ED-754F27FFDBC2

Q34077795-841D9FF6-36BD-4402-9206-D968A71A73AD

Q34077795-A510C77B-0A2E-4466-B9D7-6DB06340B273

Q34077795-D6A9E8FE-772B-4776-8801-D49014449DB9

Q34077795-EB063030-1A73-4EE5-B679-FDE47CA72BB6

Q34077795-EF1FB05A-E608-4CA2-A50A-B0031DBA2DD2

P2860

Q34077795-012E0301-8DA2-4747-9F17-43E25C95635F

Q34077795-0A104500-D382-4D68-9C1E-4867CE0024F4

Q34077795-0AB1522C-D2C6-4407-A00E-906BC9FAD8CC

Q34077795-0FDBA06F-E54D-4935-A951-2AE5BAF9314D

Q34077795-1648BD9E-F269-4569-A4D9-E31E6A4F68B7

Q34077795-16B3BA13-FE74-420F-8B0B-006F6538E738

Q34077795-1838B84F-8AA3-422A-9081-36236C17DC0E

Q34077795-1BE7057C-67E1-4EA7-948F-DB9DA8FC5BCA

Q34077795-261EEF80-1F2C-4148-9044-EC37387FA3B4

Q34077795-2B4A199B-CF66-4A5D-B82F-55A217BACB31

P304

Q34077795-2D431073-37B3-4B9A-9EBE-87F5D408E0B9

P31

Q34077795-7FE99393-1215-4AA2-AA0A-D0F05997AB81

P356

Q34077795-26198D45-14D3-4370-AB0C-8A5BE0A6C2FF

P407

Q34077795-50ED884F-70F5-4EAA-98DE-5EAF75A560B1

P433

Q34077795-B9041FEB-7B16-4EBE-9DDF-8304E50A2462

P478

Q34077795-7BC19B96-CA7D-49C6-985B-25B5206D01BE

P577

Q34077795-F02C5CC4-86E1-4CD0-AB2B-76F8A4A68904

P5875

Q34077795-1BBDD509-DB6F-407A-94D7-B8CCFCC20C07

P698

Q34077795-B63CAFAE-2641-42CB-ABDC-24E1A04DE852

P932

Q34077795-E6373792-4FE0-44FD-9612-9107F2588723

P356

J.DEVCEL.2010.06.015

P1433

Developmental Cell

P1476

The Merlin/NF2 tumor suppresso ...... tissue homeostasis in mammals.

@en

P2093

Duojia Pan

http://www.w3.org/2001/XMLSchema#string

Haibo Bai

http://www.w3.org/2001/XMLSchema#string

Jing Cai

http://www.w3.org/2001/XMLSchema#string

Jixin Dong

http://www.w3.org/2001/XMLSchema#string

Karen K David

http://www.w3.org/2001/XMLSchema#string

Marco Giovannini

http://www.w3.org/2001/XMLSchema#string

Nailing Zhang

http://www.w3.org/2001/XMLSchema#string

Pentao Liu

http://www.w3.org/2001/XMLSchema#string

Robert A Anders

http://www.w3.org/2001/XMLSchema#string

Yonggang Zheng

http://www.w3.org/2001/XMLSchema#string

P2860

Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control

Kibra functions as a tumor suppressor protein that regulates Hippo signaling in conjunction with Merlin and Expanded

Merlin/NF2 suppresses tumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleus

MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation

Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach

Mob as tumor suppressor is activated by Hippo kinase for growth inhibition in Drosophila

Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon

Structural analysis of Drosophila merlin reveals functional domains important for growth control and subcellular localization.

salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines

The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP

P304

27-38

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1016/J.DEVCEL.2010.06.015

http://www.w3.org/2001/XMLSchema#string

P407

P433

1

http://www.w3.org/2001/XMLSchema#string

P478

19

http://www.w3.org/2001/XMLSchema#string

P577

2010-07-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

45274517

http://www.w3.org/2001/XMLSchema#string

P698

20643348

http://www.w3.org/2001/XMLSchema#string

P932

2925178

http://www.w3.org/2001/XMLSchema#string