Absence of the prion protein homologue Doppel causes male sterility.
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Prion-like protein Doppel expression is not modified in scrapie-infected cells and in the brains of patients with Creutzfeldt-Jakob diseaseThe human "prion-like" protein Doppel is expressed in both Sertoli cells and spermatozoaPrion protein paralog doppel protein interacts with alpha-2-macroglobulin: a plausible mechanism for doppel-mediated neurodegenerationInteractome analyses identify ties of PrP and its mammalian paralogs to oligomannosidic N-glycans and endoplasmic reticulum-derived chaperonesCopper(II) binding to the human Doppel protein may mark its functional diversity from the prion protein.The comprehensive native interactome of a fully functional tagged prion proteinFunctionally relevant domains of the prion protein identified in vivoGenes contributing to prion pathogenesisPrion protein expression regulates embryonic stem cell pluripotency and differentiationProtease-resistant prions selectively decrease Shadoo protein.Biochemical signatures of doppel protein in human astrocytomas to support prediction in tumor malignancy.Prion protein and Shadoo are involved in overlapping embryonic pathways and trophoblastic developmentThe prion protein family: a view from the placentaRole of the prion protein family in the gonads.Is prnt a pseudogene? Identification of ram Prt in testis and ejaculated spermatozoa.Age-dependent impairment of eyeblink conditioning in prion protein-deficient mice.Differential responses of neuronal and spermatogenic cells to the doppel cytotoxicity.Male infertility and DNA damage in Doppel knockout and prion protein/Doppel double-knockout miceImpairment of spermatogenesis leading to infertility.Doppel induces degeneration of cerebellar Purkinje cells independently of BaxCellular prion protein: from physiology to pathology.Chaperone and anti-chaperone: two-faced synuclein as stimulator of synaptic evolution.A specific role for PRND in goat foetal Leydig cells is suggested by prion family gene expression during gonad development in goats and miceThe prion protein family: looking outside the central nervous system.Targeting prion-like protein doppel selectively suppresses tumor angiogenesis.Inhibition of ovine in vitro fertilization by anti-Prt antibody: hypothetical model for Prt/ZP interactionExpression profiling of mammalian male meiosis and gametogenesis identifies novel candidate genes for roles in the regulation of fertilityTransgene-driven expression of the Doppel protein in Purkinje cells causes Purkinje cell degeneration and motor impairmentThe prion protein knockout mouse: a phenotype under challenge.Activation and repression domains within the promoter of the rat cathepsin L gene orchestrate sertoli cell-specific and stage-specific gene transcription in transgenic mice.Disruption of Doppel prevents neurodegeneration in mice with extensive Prnp deletions.Prion protein (PrP) gene-knockout cell lines: insight into functions of the PrP.The protein and transcript profiles of human semen.Endoproteolytic processing of the mammalian prion glycoprotein family.Dual role of cellular prion protein in normal host and Alzheimer's disease.Expression of truncated PrP targeted to Purkinje cells of PrP knockout mice causes Purkinje cell death and ataxia.The CNS glycoprotein Shadoo has PrP(C)-like protective properties and displays reduced levels in prion infections.Stability and conformational properties of doppel, a prion-like protein, and its single-disulphide mutant.Shadoo (Sprn) and prion disease incubation time in mice.Dynamic expression of the prion-like protein Doppel in ovine testicular tissue.
P2860
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P2860
Absence of the prion protein homologue Doppel causes male sterility.
description
2002 nî lūn-bûn
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2002 թուականի Յուլիսին հրատարակուած գիտական յօդուած
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2002 թվականի հուլիսին հրատարակված գիտական հոդված
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2002年の論文
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2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
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name
Absence of the prion protein homologue Doppel causes male sterility.
@ast
Absence of the prion protein homologue Doppel causes male sterility.
@en
Absence of the prion protein homologue Doppel causes male sterility.
@nl
type
label
Absence of the prion protein homologue Doppel causes male sterility.
@ast
Absence of the prion protein homologue Doppel causes male sterility.
@en
Absence of the prion protein homologue Doppel causes male sterility.
@nl
prefLabel
Absence of the prion protein homologue Doppel causes male sterility.
@ast
Absence of the prion protein homologue Doppel causes male sterility.
@en
Absence of the prion protein homologue Doppel causes male sterility.
@nl
P2093
P2860
P356
P1433
P1476
Absence of the prion protein homologue Doppel causes male sterility.
@en
P2093
Birgit Ledermann
Frank L Heppner
Fredi Janett
Heike Naumann
Nicolas Genoud
Thomas Rülicke
P2860
P304
P356
10.1093/EMBOJ/CDF386
P407
P577
2002-07-01T00:00:00Z