Mer receptor tyrosine kinase is a novel therapeutic target in pediatric B-cell acute lymphoblastic leukemia - Wikidata - awgldk - TriplyDB

Mer receptor tyrosine kinase is a novel therapeutic target in pediatric B-cell acute lymphoblastic leukemia

Mer receptor tyrosine kinase is a novel therapeutic target in pediatric B-cell acute lymphoblastic leukemia

http://www.wikidata.org/entity/Q34080843

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Discovery of Mer kinase inhibitors by virtual screening using Structural Protein-Ligand Interaction Fingerprints.Discovery of Small Molecule Mer Kinase Inhibitors for the Treatment of Pediatric Acute Lymphoblastic Leukemia Prolonged exposure to a Mer ligand in leukemia: Gas6 favors expression of a partial Mer glycoform and reveals a novel role for Mer in the nucleus.Protein biomarkers distinguish between high- and low-risk pediatric acute lymphoblastic leukemia in a tissue specific manner.Human biosample authentication using the high-throughput, cost-effective SNPtrace(TM) system.Variable expression of PIK3R3 and PTEN in Ewing Sarcoma impacts oncogenic phenotypes.Taking aim at Mer and Axl receptor tyrosine kinases as novel therapeutic targets in solid tumors.Targeting paediatric acute lymphoblastic leukaemia: novel therapies currently in development MiR-193b, downregulated in Ewing Sarcoma, targets the ErbB4 oncogene to inhibit anchorage-independent growth.Role of c-Myb in the survival of pre B-cell acute lymphoblastic leukemia and leukemogenesis.TAM receptors in leukemia: expression, signaling, and therapeutic implications.Synthesis, biological evaluation, and physicochemical property assessment of 4-substituted 2-phenylaminoquinazolines as Mer tyrosine kinase inhibitors MERTK controls melanoma cell migration and survival and differentially regulates cell behavior relative to AXL.Macrophage-tumor crosstalk: role of TAMR tyrosine kinase receptors and of their ligands.Pharmacogenomic considerations of xenograft mouse models of acute leukemia.Pediatric relapsed or refractory leukemia: new pharmacotherapeutic developments and future directions.TAM receptor tyrosine kinase function and the immunopathology of liver disease.Deregulated MIR335 that targets MAPK1 is implicated in poor outcome of paediatric acute lymphoblastic leukaemia.Mer receptor tyrosine kinase inhibition impedes glioblastoma multiforme migration and alters cellular morphology Receptor kinase profiles identify a rationale for multitarget kinase inhibition in immature T-ALL.

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Mer receptor tyrosine kinase is a novel therapeutic target in pediatric B-cell acute lymphoblastic leukemia

http://www.wikidata.org/entity/Q34080843

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2009 nî lūn-bûn

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2009 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2009 թվականի հուլիսին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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Mer receptor tyrosine kinase i ...... l acute lymphoblastic leukemia

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Mer receptor tyrosine kinase i ...... l acute lymphoblastic leukemia

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Mer receptor tyrosine kinase i ...... l acute lymphoblastic leukemia

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Mer receptor tyrosine kinase i ...... l acute lymphoblastic leukemia

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Mer receptor tyrosine kinase i ...... l acute lymphoblastic leukemia

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Mer receptor tyrosine kinase i ...... l acute lymphoblastic leukemia

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Mer receptor tyrosine kinase i ...... l acute lymphoblastic leukemia

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Mer receptor tyrosine kinase i ...... l acute lymphoblastic leukemia

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Mer receptor tyrosine kinase i ...... l acute lymphoblastic leukemia

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Amy K Keating

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Deborah DeRyckere

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Douglas K Graham

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Kelly K Sawczyn

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Kristen M Jacobsen

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Luis Brandão

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Rachel M A Linger

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Xiayuan Liang

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P2860

Mechanism of activation of protein kinase B by insulin and IGF-1

Cloning and mRNA expression analysis of a novel human protooncogene, c-mer

Biological effects of c-Mer receptor tyrosine kinase in hematopoietic cells depend on the Grb2 binding site in the receptor and activation of NF-kappaB.

AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling

Defining the role of mTOR in cancer

Ectopic expression of the proto-oncogene Mer in pediatric T-cell acute lymphoblastic leukemia

Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias

Chromosomal translocations involving the E2A gene in acute lymphoblastic leukemia: clinical features and molecular pathogenesis

mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt

Endogenous human microRNAs that suppress breast cancer metastasis

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2678-2687

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scholarly article

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10.1182/BLOOD-2009-03-209247

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