Dose- and route-dependent teratogenicity, toxicity, and pharmacokinetic profiles of the hedgehog signaling antagonist cyclopamine in the mouse. - Wikidata - awgldk - TriplyDB

Dose- and route-dependent teratogenicity, toxicity, and pharmacokinetic profiles of the hedgehog signaling antagonist cyclopamine in the mouse.

Dose- and route-dependent teratogenicity, toxicity, and pharmacokinetic profiles of the hedgehog signaling antagonist cyclopamine in the mouse.

http://www.wikidata.org/entity/Q34082587

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Targeting the Hedgehog Pathway in Pediatric Medulloblastoma The Roles of Hedgehog Signaling in Upper Lip Formation The Role of Hedgehog Signaling in Tumor Induced Bone Disease Sonic Hedgehog in pancreatic cancer: from bench to bedside, then back to the bench Definition of critical periods for Hedgehog pathway antagonist-induced holoprosencephaly, cleft lip, and cleft palate Characterization of subtle brain abnormalities in a mouse model of Hedgehog pathway antagonist-induced cleft lip and palate Tumor shrinkage by cyclopamine tartrate through inhibiting hedgehog signaling Deciphering gene expression program of MAP3K1 in mouse eyelid morphogenesis Identification of Hedgehog signaling inhibitors with relevant human exposure by small molecule screening.SP8 regulates signaling centers during craniofacial development.Genesis of teratogen-induced holoprosencephaly in mice.MiR-153 targets the nuclear factor-1 family and protects against teratogenic effects of ethanol exposure in fetal neural stem cells.Hedgehog signaling is critical for normal liver regeneration after partial hepatectomy in mice.Cleft lip and palate results from Hedgehog signaling antagonism in the mouse: Phenotypic characterization and clinical implications Experimental approaches for the treatment of malignant gliomas.Children's Oncology Group's 2013 blueprint for research: central nervous system tumors.Hand1 phosphoregulation within the distal arch neural crest is essential for craniofacial morphogenesis.Gli1 activation and protection against hepatic encephalopathy is suppressed by circulating transforming growth factor β1 in mice.Ormeloxifene suppresses desmoplasia and enhances sensitivity of gemcitabine in pancreatic cancer Inhibition of Hedgehog signalling by NVP-LDE225 (Erismodegib) interferes with growth and invasion of human renal cell carcinoma cells Inhibition of Gli/hedgehog signaling in prostate cancer cells by "cancer bush" Sutherlandia frutescens extract.22q11 Gene dosage establishes an adaptive range for sonic hedgehog and retinoic acid signaling during early development.PTHrP treatment fails to rescue bone defects caused by Hedgehog pathway inhibition in young mice Postnatal Development of the Craniofacial Skeleton in Male C57BL/6J Mice.NODAL and SHH dose-dependent double inhibition promotes an HPE-like phenotype in chick embryos.The Hedgehog signalling pathway in breast development, carcinogenesis and cancer therapy.Quantitative high-throughput profiling of environmental chemicals and drugs that modulate farnesoid X receptor FGF-regulated BMP signaling is required for eyelid closure and to specify conjunctival epithelial cell fate.Intra-articular injection of human mesenchymal stem cells (MSCs) promote rat meniscal regeneration by being activated to express Indian hedgehog that enhances expression of type II collagen HPMA copolymer-based combination therapy toxic to both prostate cancer stem/progenitor cells and differentiated cells induces durable anti-tumor effects.Disrupting the Indian hedgehog signaling pathway in vivo attenuates surgically induced osteoarthritis progression in Col2a1-CreERT2; Ihhfl/fl mice.Additional Risk Minimisation Measures for Medicinal Products in the European Union: A Review of the Implementation and Effectiveness of Measures in the United Kingdom by One Marketing Authorisation Holder.The Hedgehog's tale: developing strategies for targeting cancer.The utility of hedgehog signaling pathway inhibition for cancer.Small molecule inhibitors of the hedgehog signaling pathway for the treatment of cancer.Indian Hedgehog, a critical modulator in osteoarthritis, could be a potential therapeutic target for attenuating cartilage degeneration disease.Sonic hedgehog signaling in Basal cell nevus syndrome.Basal cell naevus syndrome: an update on genetics and treatment.Prostate Cancer Stem Cells and Nanotechnology: A Focus on Wnt Signaling.Basal cell carcinoma pathogenesis and therapy involving hedgehog signaling and beyond.

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Dose- and route-dependent teratogenicity, toxicity, and pharmacokinetic profiles of the hedgehog signaling antagonist cyclopamine in the mouse.

http://www.wikidata.org/entity/Q34082587

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2008 nî lūn-bûn

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2008年の論文

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Dose- and route-dependent tera ...... nist cyclopamine in the mouse.

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Dose- and route-dependent tera ...... nist cyclopamine in the mouse.

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Dose- and route-dependent tera ...... nist cyclopamine in the mouse.

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Dose- and route-dependent tera ...... nist cyclopamine in the mouse.

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Dose- and route-dependent tera ...... nist cyclopamine in the mouse.

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Dose- and route-dependent tera ...... nist cyclopamine in the mouse.

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Dose- and route-dependent tera ...... nist cyclopamine in the mouse.

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Dose- and route-dependent tera ...... nist cyclopamine in the mouse.

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Ida M Washington

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Paul R Hutson

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Paul W Hannam

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Richard E Peterson

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Wade Bushman

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P2860

Repression of smoothened by patched-dependent (pro-)vitamin D3 secretion

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists

Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours

Hedgehog signaling in animal development: paradigms and principles

Patched acts catalytically to suppress the activity of Smoothened

Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function

Sonic hedgehog pathway inhibition alters epididymal function as assessed by the development of sperm motility.

Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions.

The teratogenic Veratrum alkaloid cyclopamine inhibits sonic hedgehog signal transduction.

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