Human thioredoxin reductase is efficiently inhibited by (2,2':6',2' '-terpyridine)platinum(II) complexes. Possible implications for a novel antitumor strategy.
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Glutathione reductase facilitates host defense by sustaining phagocytic oxidative burst and promoting the development of neutrophil extracellular trapsCisplatin and oxaliplatin toxicity: importance of cochlear kinetics as a determinant for ototoxicityMetal- and Semimetal-Containing Inhibitors of Thioredoxin Reductase as Anticancer AgentsMechanistic studies on a novel, highly potent gold-phosphole inhibitor of human glutathione reductaseGlutathione- and thioredoxin-related enzymes are modulated by sulfur-containing chemopreventive agentsCell death by SecTRAPs: thioredoxin reductase as a prooxidant killer of cellsCisplatin and oxaliplatin are toxic to cochlear outer hair cells and both target thioredoxin reductase in organ of Corti culturesArsenic trioxide and auranofin inhibit selenoprotein synthesis: implications for chemotherapy for acute promyelocytic leukaemia.Identification of Michael acceptor-centric pharmacophores with substituents that yield strong thioredoxin reductase inhibitory character correlated to antiproliferative activity.Differences in conformational dynamics of [Pt3(HPTAB)]6+-DNA adducts with various cross-linking modesRole of thioredoxin reductase 1 in dysplastic transformation of human breast epithelial cells triggered by chronic oxidative stressAnticancer activity of metal complexes: involvement of redox processes.Mechanistic studies on the reactions of platinum(II) complexes with nitrogen- and sulfur-donor biomolecules.Thioredoxin reductase and its inhibitors.Metal complex interactions with DNA.Antioxidant enzyme inhibitor role of phosphine metal complexes in lung and leukemia cell lines.A furanyl acryl conjugated coumarin as an efficient inhibitor and a highly selective off-on fluorescent probe for covalent labelling of thioredoxin reductase.Towards the rational design of platinum(II) and gold(III) complexes as antitumour agents.Interactions of nitroaromatic compounds with the mammalian selenoprotein thioredoxin reductase and the relation to induction of apoptosis in human cancer cells.Specific blocking of CREB/DNA binding by cyclometalated platinum(II) complexes.Luminescent cyclometalated alkynylplatinum(II) complexes with a tridentate pyridine-based N-heterocyclic carbene ligand: synthesis, characterization, electrochemistry, photophysics, and computational studies.Ruthenium polypyridyl complexes as inducer of ROS-mediated apoptosis in cancer cells by targeting thioredoxin reductase.Kinetic and mechanistic studies of 1,3-bis(2-pyridylimino)isoindolate Pt(II) derivatives. Experimental and new computational approach.Cytotoxic gold(iii) complexes incorporating a 2,2':6',2''-terpyridine ligand framework - the impact of the substituent in the 4'-position of a terpy ring.Unprecedented formation of an acetamidate-bridged dinuclear platinum(II) terpyridyl complex-correlation of luminescence properties with the crystal forms and dimerization studies in solution.Anticancer Activities of Mononuclear Ruthenium(II) Coordination Complexes
P2860
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P2860
Human thioredoxin reductase is efficiently inhibited by (2,2':6',2' '-terpyridine)platinum(II) complexes. Possible implications for a novel antitumor strategy.
description
2001 nî lūn-bûn
@nan
2001 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Human thioredoxin reductase is ...... or a novel antitumor strategy.
@ast
Human thioredoxin reductase is ...... or a novel antitumor strategy.
@en
Human thioredoxin reductase is ...... or a novel antitumor strategy.
@nl
type
label
Human thioredoxin reductase is ...... or a novel antitumor strategy.
@ast
Human thioredoxin reductase is ...... or a novel antitumor strategy.
@en
Human thioredoxin reductase is ...... or a novel antitumor strategy.
@nl
prefLabel
Human thioredoxin reductase is ...... or a novel antitumor strategy.
@ast
Human thioredoxin reductase is ...... or a novel antitumor strategy.
@en
Human thioredoxin reductase is ...... or a novel antitumor strategy.
@nl
P2093
P356
P1476
Human thioredoxin reductase is ...... or a novel antitumor strategy.
@en
P2093
P304
P356
10.1021/JM001014I
P407
P577
2001-08-01T00:00:00Z