The polypeptide tunnel system in the ribosome and its gating in erythromycin resistance mutants of L4 and L22.
about
Modulating splicing with small molecular inhibitors of the spliceosomeNegamycin Binds to the Wall of the Nascent Chain Exit Tunnel of the 50S Ribosomal SubunitThe ribosome-bound chaperones RAC and Ssb1/2p are required for accurate translation in Saccharomyces cerevisiae.Ribosome biogenesis and the translation process in Escherichia coliThe bacterial ribosome as a target for antibioticsIncreased sensitivity to protein synthesis inhibitors in cells lacking tmRNARibosomes containing mutants of L4 ribosomal protein from Thermus thermophilus display multiple defects in ribosomal functions and sensitivity against erythromycin.Side-chain recognition and gating in the ribosome exit tunnel.Rotational restriction of nascent peptides as an essential element of co-translational protein folding: possible molecular players and structural consequences.Recombineering reveals a diverse collection of ribosomal proteins L4 and L22 that confer resistance to macrolide antibiotics.Genetic identification of nascent peptides that induce ribosome stalling.Non-bulk-like solvent behavior in the ribosome exit tunnel.Large facilities and the evolving ribosome, the cellular machine for genetic-code translationNovel mechanism of resistance to oxazolidinones, macrolides, and chloramphenicol in ribosomal protein L4 of the pneumococcusBinding site of macrolide antibiotics on the ribosome: new resistance mutation identifies a specific interaction of ketolides with rRNAThe in vivo function of the ribosome-associated Hsp70, Ssz1, does not require its putative peptide-binding domain.The conformation of a nascent polypeptide inside the ribosome tunnel affects protein targeting and protein folding.Methylation of 23S rRNA nucleotide G745 is a secondary function of the RlmAI methyltransferase.Deletion of L4 domains reveals insights into the importance of ribosomal protein extensions in eukaryotic ribosome assembly.The extended loops of ribosomal proteins L4 and L22 are not required for ribosome assembly or L4-mediated autogenous controlPneumococcal resistance to macrolides, lincosamides, ketolides, and streptogramin B agents: molecular mechanisms and resistance phenotypes.Molecular markers for rapidly identifying candidate genes in Chlamydomonas reinhardtii. Ery1 and ery2 encode chloroplast ribosomal proteins.Ratchet-like movements between the two ribosomal subunits: their implications in elongation factor recognition and tRNA translocation.The active 80S ribosome-Sec61 complex.AtRH57, a DEAD-box RNA helicase, is involved in feedback inhibition of glucose-mediated abscisic acid accumulation during seedling development and additively affects pre-ribosomal RNA processing with high glucose.Dynamic reorganization of the functionally active ribosome explored by normal mode analysis and cryo-electron microscopy.Structural insight into functional aspects of ribosomal RNA targeting.Intraribosomal regulation of expression and fate of proteins.From peptide-bond formation to cotranslational folding: dynamic, regulatory and evolutionary aspects.In vitro subminimum inhibitory concentrations of macrolide antibiotics induce macrolide resistance in Mycoplasma pneumoniaeUniversal and domain-specific sequences in 23S-28S ribosomal RNA identified by computational phylogeneticsRibosomal proteins in the spotlight.Novel mutations in ribosomal proteins L4 and L22 that confer erythromycin resistance in Escherichia coli.Mutation from guanine to adenine in 25S rRNA at the position equivalent to E. coli A2058 does not confer erythromycin sensitivity in Sacchromyces cerevisae.Mutations in the Escherichia coli ribosomal protein L22 selectively suppress the expression of a secreted bacterial virulence factor.Revisiting the mechanism of macrolide-antibiotic resistance mediated by ribosomal protein L22.The extended loops of ribosomal proteins uL4 and uL22 of Escherichia coli contribute to ribosome assembly and protein translation.Tertiary interactions within the ribosomal exit tunnel.Regional discrimination and propagation of local rearrangements along the ribosomal exit tunnel.Macrolide myths.
P2860
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P2860
The polypeptide tunnel system in the ribosome and its gating in erythromycin resistance mutants of L4 and L22.
description
2001 nî lūn-bûn
@nan
2001 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
The polypeptide tunnel system ...... istance mutants of L4 and L22.
@ast
The polypeptide tunnel system ...... istance mutants of L4 and L22.
@en
The polypeptide tunnel system ...... istance mutants of L4 and L22.
@nl
type
label
The polypeptide tunnel system ...... istance mutants of L4 and L22.
@ast
The polypeptide tunnel system ...... istance mutants of L4 and L22.
@en
The polypeptide tunnel system ...... istance mutants of L4 and L22.
@nl
prefLabel
The polypeptide tunnel system ...... istance mutants of L4 and L22.
@ast
The polypeptide tunnel system ...... istance mutants of L4 and L22.
@en
The polypeptide tunnel system ...... istance mutants of L4 and L22.
@nl
P2093
P1433
P1476
The polypeptide tunnel system ...... sistance mutants of L4 and L22
@en
P2093
P304
P356
10.1016/S1097-2765(01)00293-3
P577
2001-07-01T00:00:00Z