Prolonged survival of pancreatic islet allografts mediated by adenovirus immunoregulatory transgenes.
about
Genetically engineered pancreatic beta-cell lines for cell therapy of diabetes.Lentivectors encoding immunosuppressive proteins genetically engineer pancreatic beta-cells to correct diabetes in allogeneic mice.Adenovirus RIDalphabeta complex inhibits lipopolysaccharide signaling without altering TLR4 cell surface expression.Inhibition of chemokine expression by adenovirus early region three (E3) genes.Efficacy and immunogenicity of single-dose AdVAV intranasal anthrax vaccine compared to anthrax vaccine absorbed in an aerosolized spore rabbit challenge model.Functions and mechanisms of action of the adenovirus E3 proteins.Nonhuman primate models in type 1 diabetes research.Insertion of the adenoviral E3 region into a recombinant viral vector prevents antiviral humoral and cellular immune responses and permits long-term gene expression.The adenovirus E3/10.4K-14.5K proteins down-modulate the apoptosis receptor Fas/Apo-1 by inducing its internalization.A20 inhibits cytokine-induced apoptosis and nuclear factor kappaB-dependent gene activation in islets.Expression of adenoviral E3 transgenes in beta cells prevents autoimmune diabetes.Induction of central tolerance by intrathymic inoculation of adenoviral antigens into the host thymus permits long-term gene therapy in Gunn ratsLocal expression of immunoregulatory IL-12p40 gene prolonged syngeneic islet graft survival in diabetic NOD mice.Adenovirus early region 3 transgenes expressed in beta cells prevent autoimmune diabetes in nonobese diabetic mice: effects of deleting the adenovirus death protein 11.6K.Exploiting human herpesvirus immune evasion for therapeutic gain: potential and pitfalls.Inhibition of tumor necrosis factor alpha-induced NF-kappa B activation by the adenovirus E3-10.4/14.5K complex.Transcriptional control of SV40 T-antigen expression allows a complete reversion of immortalization.Inhibition of tumor necrosis factor (TNF) signal transduction by the adenovirus group C RID complex involves downregulation of surface levels of TNF receptor 1.Mechanism for removal of tumor necrosis factor receptor 1 from the cell surface by the adenovirus RIDalpha/beta complex.Tumor necrosis factor alpha induces the adenovirus early 3 promoter by activation of NF-kappaB.Rapid clearance of syngeneic transplanted hepatocytes following transduction with E-1-deleted adenovirus indicates early host immune responses and offers novel ways for studying viral vector, target cell and host interactions.
P2860
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P2860
Prolonged survival of pancreatic islet allografts mediated by adenovirus immunoregulatory transgenes.
description
1995 nî lūn-bûn
@nan
1995 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
Prolonged survival of pancreat ...... s immunoregulatory transgenes.
@ast
Prolonged survival of pancreat ...... s immunoregulatory transgenes.
@en
Prolonged survival of pancreat ...... s immunoregulatory transgenes.
@nl
type
label
Prolonged survival of pancreat ...... s immunoregulatory transgenes.
@ast
Prolonged survival of pancreat ...... s immunoregulatory transgenes.
@en
Prolonged survival of pancreat ...... s immunoregulatory transgenes.
@nl
prefLabel
Prolonged survival of pancreat ...... s immunoregulatory transgenes.
@ast
Prolonged survival of pancreat ...... s immunoregulatory transgenes.
@en
Prolonged survival of pancreat ...... s immunoregulatory transgenes.
@nl
P2093
P2860
P356
P1476
Prolonged survival of pancreat ...... s immunoregulatory transgenes.
@en
P2093
P2860
P304
P356
10.1073/PNAS.92.15.6947
P407
P577
1995-07-01T00:00:00Z