Genetics of the LDL receptor: evidence that the mutations affecting binding and internalization are allelic.
about
Receptor-mediated endocytosis: insights from the lipoprotein receptor systemLow-density lipoprotein receptor (LDLR) family orchestrates cholesterol homeostasisThe LDL receptorMutation in LDL receptor: Alu-Alu recombination deletes exons encoding transmembrane and cytoplasmic domainsCoated pits, coated vesicles, and receptor-mediated endocytosisFinnish type of low density lipoprotein receptor gene mutation (FH-Helsinki) deletes exons encoding the carboxy-terminal part of the receptor and creates an internalization-defective phenotypeMolecular counting of low-density lipoprotein particles as individuals and small clusters on cell surfaces.Alternative hypotheses for the role of promotion in chemical carcinogenesisHomozygous familial hypercholesterolemia mutant with a defect in internalization of low density lipoproteinExon-Alu recombination deletes 5 kilobases from the low density lipoprotein receptor gene, producing a null phenotype in familial hypercholesterolemiaGenetically defined hyperlipidemia.Molecular characterization of proprotein convertase subtilisin/kexin type 9-mediated degradation of the LDLR.Inefficient internalization of receptor-bound low density lipoprotein in human carcinoma A-431 cellsFluorescent low density lipoprotein for observation of dynamics of individual receptor complexes on cultured human fibroblasts.Diffusion of low density lipoprotein-receptor complex on human fibroblasts.Electric field-induced redistribution and postfield relaxation of low density lipoprotein receptors on cultured human fibroblasts.Role of the human transferrin receptor cytoplasmic domain in endocytosis: localization of a specific signal sequence for internalization.Role of FQQI motif in the internalization, trafficking, and signaling of guanylyl-cyclase/natriuretic peptide receptor-A in cultured murine mesangial cellsTargeted killing of cultured cells by receptor-dependent photosensitization.Quantitative fluorescence imaging reveals point of release for lipoproteins during LDLR-dependent uptake.Familial hypercholesterolemia. Evidence for a newly recognized mutation determining increased fibroblast receptor affinity but decreased capacity for low density lipoprotein in two siblings.Effects of ML-236b (compactin) on sterol synthesis and low density lipoprotein receptor activities in fibroblasts of patients with homozygous familial hypercholesterolemia.Metabolic studies in familial hypercholesterolemia. Evidence for a gene-dosage effect in vivo.Genetics of the low density lipoprotein receptor. Diminished receptor activity in lymphocytes from heterozygotes with familial hypercholesterolemiaRate and equilibrium constants for binding of apo-E HDLc (a cholesterol-induced lipoprotein) and low density lipoproteins to human fibroblasts: evidence for multiple receptor binding of apo-E HDLc.Amyloid protein SAA is an apoprotein of mouse plasma high density lipoprotein.LDL apheresis and inflammation--implications for atherosclerosis.Lipoprotein receptors in extraembryonic tissues of the chicken.Low-Density Lipoprotein Receptor-Related Protein 6 (LRP6) Is a Novel Nutritional Therapeutic Target for Hyperlipidemia, Non-Alcoholic Fatty Liver Disease, and Atherosclerosis.Chinese hamster cell mutant resistant to ML236B (Compactin) is defective in endocytosis of low-density lipo-protein.The two mannose 6-phosphate binding sites of the insulin-like growth factor-II/mannose 6-phosphate receptor display different ligand binding properties.Identification of a VLDL-induced, FDNPVY-independent internalization mechanism for the LDLR.Use of metabolic inhibitors to investigate the excision repair of pyrimidine dimers and non-dimer DNA damages induced in human and ICR 2A frog cells by solar ultraviolet radiation.Diseases determined by major genes.
P2860
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P2860
Genetics of the LDL receptor: evidence that the mutations affecting binding and internalization are allelic.
description
1977 nî lūn-bûn
@nan
1977 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1977 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1977年の論文
@ja
1977年論文
@yue
1977年論文
@zh-hant
1977年論文
@zh-hk
1977年論文
@zh-mo
1977年論文
@zh-tw
1977年论文
@wuu
name
Genetics of the LDL receptor: ...... d internalization are allelic.
@ast
Genetics of the LDL receptor: ...... d internalization are allelic.
@en
Genetics of the LDL receptor: ...... d internalization are allelic.
@nl
type
label
Genetics of the LDL receptor: ...... d internalization are allelic.
@ast
Genetics of the LDL receptor: ...... d internalization are allelic.
@en
Genetics of the LDL receptor: ...... d internalization are allelic.
@nl
prefLabel
Genetics of the LDL receptor: ...... d internalization are allelic.
@ast
Genetics of the LDL receptor: ...... d internalization are allelic.
@en
Genetics of the LDL receptor: ...... d internalization are allelic.
@nl
P2093
P1433
P1476
Genetics of the LDL receptor: ...... d internalization are allelic.
@en
P2093
J L Goldstein
P304
P356
10.1016/0092-8674(77)90263-X
P407
P577
1977-11-01T00:00:00Z