Activated protein C targets CD8+ dendritic cells to reduce the mortality of endotoxemia in mice.
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Pharmacological targeting of the thrombomodulin-activated protein C pathway mitigates radiation toxicityDelayed graft function in the kidney transplantHost innate immune responses to sepsisProtein C anticoagulant and cytoprotective pathwaysEndothelial protein C receptor function in murine and human breast cancer developmentActivated factor X signaling via protease-activated receptor 2 suppresses pro-inflammatory cytokine production from lipopolysaccharide-stimulated myeloid cells.Inflammation-associated activation of coagulation and immune regulation by the protein C pathway.New players in the sepsis-protective activated protein C pathway.Endothelial cell protein C receptor: a multiliganded and multifunctional receptorThe endothelial protein C receptor supports tissue factor ternary coagulation initiation complex signaling through protease-activated receptors.Overexpression of the endothelial protein C receptor is detrimental during pneumonia-derived gram-negative sepsis (Melioidosis).Streptococcal SpeB cleaved PAR-1 suppresses ERK phosphorylation and blunts thrombin-induced platelet aggregation.The occupancy of endothelial protein C receptor by its ligand modulates the par-1 dependent signaling specificity of coagulation proteasesDendritic cells promote pancreatic viability in mice with acute pancreatitis.Activated protein C: biased for translation.EPCR-dependent PAR2 activation by the blood coagulation initiation complex regulates LPS-triggered interferon responses in mice.Activated protein C modulates the proinflammatory activity of dendritic cells.Defibrotide interferes with several steps of the coagulation-inflammation cycle and exhibits therapeutic potential to treat severe malariaActivated protein C inhibits pancreatic islet inflammation, stimulates T regulatory cells, and prevents diabetes in non-obese diabetic (NOD) mice.Extracellular histones inhibit efferocytosis.Protease-activated receptor-1 cleaved at R46 mediates cytoprotective effects.Coagulation factor V mediates inhibition of tissue factor signaling by activated protein C in miceCytoprotective protein C pathways and implications for stroke and neurological disordersAntibody SPC-54 provides acute in vivo blockage of the murine protein C system.Organ-specific protection against lipopolysaccharide-induced vascular leak is dependent on the endothelial protein C receptor.Activated protein C analog promotes neurogenesis and improves neurological outcome after focal ischemic stroke in mice via protease activated receptor 1Protease-activated receptors in hemostasis.Protein C receptor (PROCR) is a negative regulator of Th17 pathogenicity.Protein C anticoagulant system--anti-inflammatory effects.Endothelium--role in regulation of coagulation and inflammation.The endothelial cell protein C receptor: cell surface conductor of cytoprotective coagulation factor signaling.Paediatric presentation and outcome of congenital protein C deficiency in Japan.The inflammatory actions of coagulant and fibrinolytic proteases in disease.2016 Scientific Sessions Sol Sherry Distinguished Lecturer in Thrombosis: Thrombotic Stroke: Neuroprotective Therapy by Recombinant-Activated Protein C.Impact of thrombosis on pulmonary endothelial injury and repair following sepsis.Activated protein C protects from GvHD via PAR2/PAR3 signalling in regulatory T-cells.Gain in translation: heme oxygenase-1 induced by activated protein C promotes thrombus resolution.Lung cancer: new therapeutic targets, new definitions.Neurotoxicity of the anticoagulant-selective E149A-activated protein C variant after focal ischemic stroke in mice.PAR1 Biased Signaling is Required for Activated Protein C In Vivo Benefits in Sepsis and Stroke.
P2860
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P2860
Activated protein C targets CD8+ dendritic cells to reduce the mortality of endotoxemia in mice.
description
2010 nî lūn-bûn
@nan
2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Activated protein C targets CD ...... tality of endotoxemia in mice.
@ast
Activated protein C targets CD ...... tality of endotoxemia in mice.
@en
Activated protein C targets CD ...... tality of endotoxemia in mice.
@nl
type
label
Activated protein C targets CD ...... tality of endotoxemia in mice.
@ast
Activated protein C targets CD ...... tality of endotoxemia in mice.
@en
Activated protein C targets CD ...... tality of endotoxemia in mice.
@nl
prefLabel
Activated protein C targets CD ...... tality of endotoxemia in mice.
@ast
Activated protein C targets CD ...... tality of endotoxemia in mice.
@en
Activated protein C targets CD ...... tality of endotoxemia in mice.
@nl
P2093
P2860
P356
P1476
Activated protein C targets CD ...... rtality of endotoxemia in mice
@en
P2093
Claudia S Huettner
Edward Kerschen
Francis J Castellino
Hartmut Weiler
Irene Hernandez
Jose A Fernandez
Martin J Hessner
Shuang Jia
P2860
P304
P356
10.1172/JCI42629
P407
P577
2010-08-16T00:00:00Z