Expression of oncogenic K-ras and loss of Smad4 cooperate to induce the expression of EGFR and to promote invasion of immortalized human pancreas ductal cells.
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Comparison of the cancer gene targeting and biochemical selectivities of all targeted kinase inhibitors approved for clinical useEGF receptor is required for KRAS-induced pancreatic tumorigenesisSMAD4 loss triggers the phenotypic changes of pancreatic ductal adenocarcinoma cellsPermissiveness of human cancer cells to oncolytic bovine herpesvirus 1 is mediated in part by KRAS activityCooperativity of oncogenic K-ras and downregulated p16/INK4A in human pancreatic tumorigenesis.RGS16, a novel p53 and pRb cross-talk candidate inhibits migration and invasion of pancreatic cancer cells.Oncogenic K-Ras and loss of Smad4 mediate invasion by activating an EGFR/NF-κB Axis that induces expression of MMP9 and uPA in human pancreas progenitor cells.Loss of canonical Smad4 signaling promotes KRAS driven malignant transformation of human pancreatic duct epithelial cells and metastasis.Reolysin is a novel reovirus-based agent that induces endoplasmic reticular stress-mediated apoptosis in pancreatic cancer.Bmi1 combines with oncogenic KRAS to induce malignant transformation of human pancreatic duct cells in vitro.Stiffness of pancreatic cancer cells is associated with increased invasive potential.KRas induces a Src/PEAK1/ErbB2 kinase amplification loop that drives metastatic growth and therapy resistance in pancreatic cancer.Inactivation of TGFβ receptor II signalling in pancreatic epithelial cells promotes acinar cell proliferation, acinar-to-ductal metaplasia and fibrosis during pancreatitis.The K-Ras effector p38γ MAPK confers intrinsic resistance to tyrosine kinase inhibitors by stimulating EGFR transcription and EGFR dephosphorylation.
P2860
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P2860
Expression of oncogenic K-ras and loss of Smad4 cooperate to induce the expression of EGFR and to promote invasion of immortalized human pancreas ductal cells.
description
2010 nî lūn-bûn
@nan
2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Expression of oncogenic K-ras ...... d human pancreas ductal cells.
@ast
Expression of oncogenic K-ras ...... d human pancreas ductal cells.
@en
Expression of oncogenic K-ras ...... d human pancreas ductal cells.
@nl
type
label
Expression of oncogenic K-ras ...... d human pancreas ductal cells.
@ast
Expression of oncogenic K-ras ...... d human pancreas ductal cells.
@en
Expression of oncogenic K-ras ...... d human pancreas ductal cells.
@nl
prefLabel
Expression of oncogenic K-ras ...... d human pancreas ductal cells.
@ast
Expression of oncogenic K-ras ...... d human pancreas ductal cells.
@en
Expression of oncogenic K-ras ...... d human pancreas ductal cells.
@nl
P2093
P2860
P356
P1476
Expression of oncogenic K-ras ...... d human pancreas ductal cells.
@en
P2093
James W Freeman
Michel M Ouellette
Shujie Zhao
Yubao Wang
P2860
P304
P356
10.1002/IJC.25412
P577
2010-11-01T00:00:00Z