Gamma-secretase inhibitors enhance temozolomide treatment of human gliomas by inhibiting neurosphere repopulation and xenograft recurrence - Wikidata - awgldk - TriplyDB

Gamma-secretase inhibitors enhance temozolomide treatment of human gliomas by inhibiting neurosphere repopulation and xenograft recurrence

Gamma-secretase inhibitors enhance temozolomide treatment of human gliomas by inhibiting neurosphere repopulation and xenograft recurrence

http://www.wikidata.org/entity/Q34101839

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Targeting Notch to overcome radiation resistance Brain tumor stem cells: Molecular characteristics and their impact on therapy The novel gamma secretase inhibitor RO4929097 reduces the tumor initiating potential of melanoma NOTCH1 inhibition in vivo results in mammary tumor regression and reduced mammary tumorsphere-forming activity in vitro A Notch1-neuregulin1 autocrine signaling loop contributes to melanoma growth.Deltex-1 activates mitotic signaling and proliferation and increases the clonogenic and invasive potential of U373 and LN18 glioblastoma cells and correlates with patient survival Protective properties of radio-chemoresistant glioblastoma stem cell clones are associated with metabolic adaptation to reduced glucose dependence.Notch signaling activation in pediatric low-grade astrocytoma Na/K-ATPase mimetic pNaKtide peptide inhibits the growth of human cancer cells.Chemoresistance of glioblastoma cancer stem cells--much more complex than expected.Quantitative MRI establishes the efficacy of PI3K inhibitor (GDC-0941) multi-treatments in PTEN-deficient mice lymphoma Analysis of SOX2-Regulated Transcriptome in Glioma Stem Cells Metformin and temozolomide act synergistically to inhibit growth of glioma cells and glioma stem cells in vitro and in vivo.Biological and clinical implications of cancer stem cells in primary brain tumors.Synergistic effect of the γ-secretase inhibitor PF-03084014 and docetaxel in breast cancer models.Prolonged inhibition of glioblastoma xenograft initiation and clonogenic growth following in vivo Notch blockade The Notch signaling pathway as a mediator of tumor survival Molecular Pathways: Targeting Cancer Stem Cells Awakened by Chemotherapy to Abrogate Tumor Repopulation.RBPJ maintains brain tumor-initiating cells through CDK9-mediated transcriptional elongation.Essential gene pathways for glioblastoma stem cells: clinical implications for prevention of tumor recurrence.Connexin 43 Inhibition Sensitizes Chemoresistant Glioblastoma Cells to Temozolomide.NOTCH blockade combined with radiation therapy and temozolomide prolongs survival of orthotopic glioblastoma.ER stress in temozolomide-treated glioblastomas interferes with DNA repair and induces apoptosis.Mathematical modeling of PDGF-driven glioblastoma reveals optimized radiation dosing schedules A high Notch pathway activation predicts response to γ secretase inhibitors in proneural subtype of glioma tumor-initiating cells.Cancer stem cells in glioma: challenges and opportunities.EFEMP1 induces γ-secretase/Notch-mediated temozolomide resistance in glioblastoma.Notch signalling in solid tumours: a little bit of everything but not all the time.Molecular targeted therapy in recurrent glioblastoma: current challenges and future directions.Glioma stem cells: turpis omen in nomen? (The evil in the name?).The molecular mechanisms underlying the therapeutic resistance of cancer stem cells.Notching on Cancer's Door: Notch Signaling in Brain Tumors.Effect of Notch expression in glioma stem cells on therapeutic response to chemo-radiotherapy in recurrent glioblastoma.Lateral inhibition of Notch signaling in neoplastic cells.PARP inhibition restores extrinsic apoptotic sensitivity in glioblastoma.Evaluation of novel imidazotetrazine analogues designed to overcome temozolomide resistance and glioblastoma regrowth.Fatty acid binding protein 7 as a marker of glioma stem cells.MicroRNA-125b inhibitor sensitizes human primary glioblastoma cells to chemotherapeutic drug temozolomide on invasion.Level of Notch activation determines the effect on growth and stem cell-like features in glioblastoma multiforme neurosphere cultures.Harmine hydrochloride inhibits Akt phosphorylation and depletes the pool of cancer stem-like cells of glioblastoma.

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Gamma-secretase inhibitors enhance temozolomide treatment of human gliomas by inhibiting neurosphere repopulation and xenograft recurrence

http://www.wikidata.org/entity/Q34101839

description

2010 nî lūn-bûn

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2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի օգոստոսին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Gamma-secretase inhibitors enh ...... ation and xenograft recurrence

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Gamma-secretase inhibitors enh ...... ation and xenograft recurrence

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Gamma-secretase inhibitors enh ...... ation and xenograft recurrence

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Gamma-secretase inhibitors enh ...... ation and xenograft recurrence

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Gamma-secretase inhibitors enh ...... ation and xenograft recurrence

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Gamma-secretase inhibitors enh ...... ation and xenograft recurrence

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Gamma-secretase inhibitors enh ...... ation and xenograft recurrence

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Gamma-secretase inhibitors enh ...... ation and xenograft recurrence

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Gamma-secretase inhibitors enh ...... ation and xenograft recurrence

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0008-5472.CAN-10-1378

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Cancer Research

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Gamma-secretase inhibitors enh ...... ation and xenograft recurrence

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Alonzo H Ross

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Candace A Gilbert

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Marie-Claire Daou

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Richard P Moser

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P2860

Therapeutic antibody targeting of individual Notch receptors

Glioma stem cells promote radioresistance by preferential activation of the DNA damage response

Identification and expansion of human colon-cancer-initiating cells

Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma

Identification of human brain tumour initiating cells

Identification of a cancer stem cell in human brain tumors

Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system

Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma

Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines

Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties

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6870-6879

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scholarly article

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10.1158/0008-5472.CAN-10-1378

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17

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