Sorafenib activates CD95 and promotes autophagy and cell death via Src family kinases in gastrointestinal tumor cells. - Wikidata - awgldk - TriplyDB

Sorafenib activates CD95 and promotes autophagy and cell death via Src family kinases in gastrointestinal tumor cells.

Sorafenib activates CD95 and promotes autophagy and cell death via Src family kinases in gastrointestinal tumor cells.

http://www.wikidata.org/entity/Q34104350

about

Modulation of Autophagy by Sorafenib: Effects on Treatment Response Sorafenib and HDAC inhibitors synergize with TRAIL to kill tumor cells.Pazopanib and HDAC inhibitors interact to kill sarcoma cells.ABT-263 enhances sorafenib-induced apoptosis associated with Akt activity and the expression of Bax and p21((CIP1/WAF1)) in human cancer cells.C-Src and c-Yes are two unlikely partners of spermatogenesis and their roles in blood-testis barrier dynamics.Sorafenib/regorafenib and lapatinib interact to kill CNS tumor cells.zVAD-induced autophagic cell death requires c-Src-dependent ERK and JNK activation and reactive oxygen species generation.Sorafenib enhances pemetrexed cytotoxicity through an autophagy-dependent mechanism in cancer cells.Autophagy activation in the injured photoreceptor inhibits fas-mediated apoptosis.PHY906(KD018), an adjuvant based on a 1800-year-old Chinese medicine, enhanced the anti-tumor activity of Sorafenib by changing the tumor microenvironment.Combination of the deacetylase inhibitor panobinostat and the multi-kinase inhibitor sorafenib for the treatment of metastatic hepatocellular carcinoma - review of the underlying molecular mechanisms and first case report.Lapatinib and obatoclax kill tumor cells through blockade of ERBB1/3/4 and through inhibition of BCL-XL and MCL-1.Nanotechnology combined therapy: tyrosine kinase-bound gold nanorod and laser thermal ablation produce a synergistic higher treatment response of renal cell carcinoma in a murine model.Autophagy regulates UBC9 levels during viral-mediated tumorigenesis.The sorafenib plus nutlin-3 combination promotes synergistic cytotoxicity in acute myeloid leukemic cells irrespectively of FLT3 and p53 status Nexavar/Stivarga and viagra interact to kill tumor cells.GRP78/Dna K Is a Target for Nexavar/Stivarga/Votrient in the Treatment of Human Malignancies, Viral Infections and Bacterial Diseases.Sorafenib and pemetrexed toxicity in cancer cells is mediated via SRC-ERK signaling Epigenetics and colorectal cancer pathogenesis Phase I study of pemetrexed with sorafenib in advanced solid tumors.Combining histone deacetylase inhibitors with MDA-7/IL-24 enhances killing of renal carcinoma cells HDAC inhibitors enhance the lethality of low dose salinomycin in parental and stem-like GBM cells The HDAC inhibitor AR42 interacts with pazopanib to kill trametinib/dabrafenib-resistant melanoma cells in vitro and in vivo.Autophagic action of new targeting agents in head and neck oncology.The role of cell signalling in the crosstalk between autophagy and apoptosis.Histone deacetylase inhibitors and cell death.Generation of reactive oxygen species during apoptosis induced by DNA-damaging agents and/or histone deacetylase inhibitors.[pemetrexed + sildenafil], via autophagy-dependent HDAC down-regulation, enhances the immunotherapy response of NSCLC cells.Antiangiogenic tyrosine kinase inhibitors in colorectal cancer: is there a path to making them more effective?Histone Deacetylase Inhibitors as Anticancer Drugs.Sorafenib reverses resistance of gastric cancer to treatment by cisplatin through down-regulating MDR1 expression.Src mediates extracellular signal-regulated kinase 1/2 activation and autophagic cell death induced by cardiac glycosides in human non-small cell lung cancer cell lines.Suppression of autophagy by CUB domain-containing protein 1 signaling is essential for anchorage-independent survival of lung cancer cells.Inhibition of autophagy signiﬁcantly enhances combination therapy with sorafenib and HDAC inhibitors for human hepatoma cells.Sorafenib and HDAC inhibitors synergize to kill CNS tumor cells.Therapeutic implications of bioactive sphingolipids: A focus on colorectal cancer.Inhibition of autophagy potentiates the antitumor effect of the multikinase inhibitor sorafenib in hepatocellular carcinoma.HDAC inhibitors enhance the immunotherapy response of melanoma cells.

P2860

Q26745320-D7AE215A-C2C5-481F-AA2F-5F29B90A73D4 Q33576187-F6C85AF2-4EE6-4B88-8C50-5AF319A6E205 Q33631472-1EFA09AB-E65C-4767-84FC-C10E8287A892 Q33842714-3E2FD3A7-4000-4198-8AC2-F25ABD4AAEE1 Q33966470-D2592E8D-656C-4FDB-878F-A85DB17A79F3 Q34276149-548AA0A2-BF87-439A-BCCB-A8A0DB233D6F Q34577400-252C67E0-7346-4DFD-B274-39ED597CED16 Q35113327-A203281D-1622-4F84-BFC9-02CBBB5DEF54 Q35220985-85D2FA2B-9EDA-4A0B-A756-6D6422E1D950 Q35227285-25BFC4A0-8297-46A0-A9DB-AD3A8369D9C3 Q35895346-0BD0370F-3C0D-4A57-8044-6AE07330AA0A Q35913109-2A03856B-9B82-4C25-B065-3814DA07E071 Q36080927-61848259-E0D6-4169-87B9-CAAE660F7D5A Q36295602-BD2AE0E2-1A70-413B-8738-A92B575BC64F Q36366626-3E76AE52-FF07-4BD1-A869-43A1F7FFD545 Q36808335-BA5433E4-5210-4357-AEA9-198627D649F4 Q36830763-A5E9BEE7-02C6-4DBE-94FC-7B4B30E7C066 Q36919811-315ACDD0-6D8A-4490-8CEA-8C67EF0E8738 Q37061792-591AD63C-051B-42C1-8F36-E3E2761A1F7B Q37520649-9B2CE765-B23E-4324-958B-0A670F1FA72F Q37586906-7CD08D7E-52FB-4E3F-978D-CBF03D19D304 Q37683049-1AED0DC9-C09D-48A5-916C-4510A271F5AD Q37725434-174A0F0D-94EE-4550-BAFC-725EB7C9DBD3 Q38028794-8ED1EEA1-377A-4123-89C6-72979A23D05B Q38168965-20FD64A1-0F12-4B4D-8023-9B6D56484830 Q38217666-A6ACF06C-F9AB-49EE-8EAE-259C948EA11B Q38543089-AB5ED7E1-1FEB-4F92-8DF0-1081719BB629 Q38622540-8528C123-CCBF-4919-ADCA-9025A6B10F2F Q38672966-9844E9BD-6EB5-4584-9C19-B67A0E20D987 Q38696932-C78DD539-09C0-4761-8452-109E9E598555 Q38921009-990D2E6D-03C4-4C0C-AC58-EBFB706420A4 Q39017201-9B6FE37D-7CE7-4F22-8BB4-AA400846668F Q39178569-BA2255AC-523A-4DBB-AFA3-BA9E0708137C Q39206134-AE657683-A992-40E2-9AE5-FC6804AAAA2A Q39381898-F1B43298-1BCE-4556-B60F-0116A7E74214 Q39420607-905218B9-D618-4642-8665-7FD59EE229D6 Q39486469-9E6C8106-0059-43C4-9C2D-90AF17753168 Q45072959-0F1A74D4-E1A3-42D9-852B-E1AFE29EF33F

P2860

Sorafenib activates CD95 and promotes autophagy and cell death via Src family kinases in gastrointestinal tumor cells.

http://www.wikidata.org/entity/Q34104350

description

2010 nî lūn-bûn

@nan

2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

Sorafenib activates CD95 and p ...... gastrointestinal tumor cells.

@ast

Sorafenib activates CD95 and p ...... gastrointestinal tumor cells.

@en

Sorafenib activates CD95 and p ...... gastrointestinal tumor cells.

@nl

type

label

Sorafenib activates CD95 and p ...... gastrointestinal tumor cells.

@ast

Sorafenib activates CD95 and p ...... gastrointestinal tumor cells.

@en

Sorafenib activates CD95 and p ...... gastrointestinal tumor cells.

@nl

prefLabel

Sorafenib activates CD95 and p ...... gastrointestinal tumor cells.

@ast

Sorafenib activates CD95 and p ...... gastrointestinal tumor cells.

@en

Sorafenib activates CD95 and p ...... gastrointestinal tumor cells.

@nl

P1433

Q34104350-EA30DB22-9A94-4E26-813F-4C8D21DDBF96

P1476

Q34104350-3A3B1801-5B8E-473A-A181-F05B981417DE

P2093

Q34104350-0638438A-F8B9-468F-ADB7-2DCA0CC98428

Q34104350-4D29D6E2-C994-47D4-BF51-3775008BFD5D

Q34104350-8525F2F6-6E7C-4E44-80EE-814327D204AD

Q34104350-AF7A761E-34D4-4F02-85B7-56251A6806B7

Q34104350-BC55852E-5A60-4616-890D-793A7D7E23E0

Q34104350-DDDFE3AC-2D80-4136-BEF2-355902E424F9

P2860

Q34104350-016D37F5-03DC-4ECC-9AFA-69BB584DED64

Q34104350-0C298D3A-6279-43C8-AD02-6B459B111C51

Q34104350-10C56C29-E119-4198-9CAF-EF0AA6866A24

Q34104350-147E4DD1-A9FA-4589-B43F-121EA5CC38C8

Q34104350-2B56FA6D-AF7B-433B-AF71-C0BC2FFB2A44

Q34104350-2E4BE209-2310-460D-9F54-AC2AF340A49E

Q34104350-336C3D58-ABBB-4C96-8314-8219EAD7DA15

Q34104350-3F8907F8-EF8E-4D5A-BDE9-FE626613FCE3

Q34104350-434B3299-63A6-4AFA-8C64-2DA87B979CC1

Q34104350-49326E12-9751-4577-ABA9-A7534CF80F71

P304

Q34104350-03A7B1DF-6199-48FF-B628-44AFA325D436

P31

Q34104350-96FAA6A5-F489-41D2-A085-87BFA4EA639D

P356

Q34104350-9B6044DC-9195-412C-9A5F-54FC672A1C46

P433

Q34104350-B83E32F5-A519-48C8-AA0E-B7FDAF3D3953

P478

Q34104350-166262CD-66D4-44A0-A3B4-8FA5CE1C9DBE

P50

Q34104350-2172157E-D4AE-4F4B-9F9C-A992855C9A2C

Q34104350-63B25A37-7B9E-432A-AF43-D31E1C35683A

P577

Q34104350-2128E955-21FA-4C72-9414-1F21071DC00D

P698

Q34104350-741701F9-CA5B-46F3-BF47-618498D98D2D

P921

Q34104350-7784030D-3AE0-417F-8FE1-EA89F2426099

P932

Q34104350-E930EF99-2946-4EF6-8E5D-0D34842A4866

P356

1535-7163.MCT-10-0274

P1433

Molecular Cancer Therapeutics

P1476

Sorafenib activates CD95 and p ...... gastrointestinal tumor cells.

@en

P2093

Adly Yacoub

http://www.w3.org/2001/XMLSchema#string

Besim Ogretmen

http://www.w3.org/2001/XMLSchema#string

Christina Voelkel-Johnson

http://www.w3.org/2001/XMLSchema#string

Margaret A Park

http://www.w3.org/2001/XMLSchema#string

Roland Reinehr

http://www.w3.org/2001/XMLSchema#string

Steven Grant

http://www.w3.org/2001/XMLSchema#string

P2860

Global cancer statistics, 2002

Multiple cyclin kinase inhibitors promote bile acid-induced apoptosis and autophagy in primary hepatocytes via p53-CD95-dependent signaling

Bile acid regulation of C/EBPbeta, CREB, and c-Jun function, via the extracellular signal-regulated kinase and c-Jun NH2-terminal kinase pathways, modulates the apoptotic response of hepatocytes.

Genetic and epigenetic silencing of SCARA5 may contribute to human hepatocellular carcinoma by activating FAK signaling.

Deoxycholic acid (DCA) causes ligand-independent activation of epidermal growth factor receptor (EGFR) and FAS receptor in primary hepatocytes: inhibition of EGFR/mitogen-activated protein kinase-signaling module enhances DCA-induced apoptosis.

Histone acetylation and chromatin remodeling.

A role for both Ets and C/EBP transcription factors and mRNA stabilization in the MAPK-dependent increase in p21 (Cip-1/WAF1/mda6) protein levels in primary hepatocytes.

Inhibition of MEK/ERK1/2 sensitizes lymphoma cells to sorafenib-induced apoptosis

Histone deacetylases.

MAPK pathways in radiation responses.

P304

2220-2231

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1158/1535-7163.MCT-10-0274

http://www.w3.org/2001/XMLSchema#string

P433

8

http://www.w3.org/2001/XMLSchema#string

P478

9

http://www.w3.org/2001/XMLSchema#string

P50

Dieter Häussinger

P577

2010-08-03T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

20682655

http://www.w3.org/2001/XMLSchema#string

P921

P932

2933415

http://www.w3.org/2001/XMLSchema#string