Natural product-like macrocyclic N-methyl-peptide inhibitors against a ubiquitin ligase uncovered from a ribosome-expressed de novo library.
about
Cyclic and Macrocyclic Peptides as Chemical Tools To Recognise Protein Surfaces and Probe Protein-Protein InteractionsTargeting the ubiquitin pathway for cancer treatmentStructural basis for gating mechanisms of a eukaryotic P-glycoprotein homolog.Structural basis for the drug extrusion mechanism by a MATE multidrug transporterA current perspective on applications of macrocyclic-peptide-based high-affinity ligandsRecent developments of engineered translational machineries for the incorporation of non-canonical amino acids into polypeptidesPeptide library approach to uncover phosphomimetic inhibitors of the BRCA1 C-terminal domainA highly scalable peptide-based assay system for proteomicsSynthetic biology challenges long-held hypotheses in translation, codon bias and transcription.E3 Ubiquitin Ligases Neurobiological Mechanisms: Development to DegenerationAnatomy of β-strands at protein-protein interfaces.Discovery of macrocyclic peptides armed with a mechanism-based warhead: isoform-selective inhibition of human deacetylase SIRT2.In vitro selection of highly modified cyclic peptides that act as tight binding inhibitors.Structurally diverse cyclisation linkers impose different backbone conformations in bicyclic peptides.Genetically encoded libraries of nonstandard peptides.In vitro selection of a photo-responsive peptide aptamer using ribosome display.Technologies for the synthesis of mRNA-encoding libraries and discovery of bioactive natural product-inspired non-traditional macrocyclic peptides.Flexizyme-mediated genetic reprogramming as a tool for noncanonical peptide synthesis and drug discovery.Screening bicyclic peptide libraries for protein-protein interaction inhibitors: discovery of a tumor necrosis factor-α antagonistDevelopment of Next-Generation Peptide Binders Using In vitro Display Technologies and Their Potential Applications.Methods for the creation of cyclic Peptide libraries for use in lead discovery.Ribosomal Synthesis of Macrocyclic Peptides in Vitro and in Vivo Mediated by Genetically Encoded Aminothiol Unnatural Amino AcidsConceptual and methodological advances in cell-free directed evolution.Dihydrofolate reductase inhibitory peptides screened from a structured designed β-loop peptide library displayed on phage.Discovering functional, non-proteinogenic amino acid containing, peptides using genetic code reprogramming.In Vitro Selection Combined with Ribosomal Translation Containing Non-proteinogenic Amino Acids.Expanding the amino acid repertoire of ribosomal polypeptide synthesis via the artificial division of codon boxes.Conformational Restriction of Peptides Using Dithiol Bis-AlkylationA RaPID way to discover nonstandard macrocyclic peptide modulators of drug targets.Macrocycle peptides delineate locked-open inhibition mechanism for microorganism phosphoglycerate mutases.Linker-free incorporation of carbohydrates into in vitro displayed macrocyclic peptides.New Strategies to Direct Therapeutic Targeting of PML to Treat CancersEngineering the substrate specificity of the DhbE adenylation domain by yeast cell surface display.N-methylation of peptides and proteins: an important element for modulating biological functions.Expansion of the aptamer library from a "natural soup" to an "unnatural soup".Generation and selection of ribozyme variants with potential application in protein engineering and synthetic biology.PML tumour suppression and beyond: therapeutic implications.Screening for E3-ubiquitin ligase inhibitors: challenges and opportunities.Highly selective inhibition of histone demethylases by de novo macrocyclic peptides.Restoration of tumor suppression in prostate cancer by targeting the E3 ligase E6AP.
P2860
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P2860
Natural product-like macrocyclic N-methyl-peptide inhibitors against a ubiquitin ligase uncovered from a ribosome-expressed de novo library.
description
2011 nî lūn-bûn
@nan
2011 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Natural product-like macrocycl ...... ome-expressed de novo library.
@ast
Natural product-like macrocycl ...... ome-expressed de novo library.
@en
Natural product-like macrocycl ...... ome-expressed de novo library.
@nl
type
label
Natural product-like macrocycl ...... ome-expressed de novo library.
@ast
Natural product-like macrocycl ...... ome-expressed de novo library.
@en
Natural product-like macrocycl ...... ome-expressed de novo library.
@nl
prefLabel
Natural product-like macrocycl ...... ome-expressed de novo library.
@ast
Natural product-like macrocycl ...... ome-expressed de novo library.
@en
Natural product-like macrocycl ...... ome-expressed de novo library.
@nl
P2093
P1476
Natural product-like macrocycl ...... some-expressed de novo library
@en
P2093
Hiroaki Suga
Ikuo Shoji
Shoji Miyagawa
Takashi Kawakami
Yusuke Yamagishi
P304
P356
10.1016/J.CHEMBIOL.2011.09.013
P577
2011-12-01T00:00:00Z