Reduced expression of IFIH1 is protective for type 1 diabetes. - Wikidata - awgldk - TriplyDB

Reduced expression of IFIH1 is protective for type 1 diabetes.

Reduced expression of IFIH1 is protective for type 1 diabetes.

http://www.wikidata.org/entity/Q34115336

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Dysregulation of antiviral helicase pathways in systemic lupus erythematosus Immune signaling by RIG-I-like receptors Intracellular nucleic acid sensors and autoimmunity TLR7/9 versus TLR3/MDA5 signaling during virus infections and diabetes Human β-Defensin 3 [corrected] Exacerbates MDA5 but Suppresses TLR3 Responses to the Viral Molecular Pattern Mimic Polyinosinic:Polycytidylic Acid Admixture mapping in lupus identifies multiple functional variants within IFIH1 associated with apoptosis, inflammation, and autoantibody production Dissection of a Complex Disease Susceptibility Region Using a Bayesian Stochastic Search Approach to Fine Mapping A type I interferon transcriptional signature precedes autoimmunity in children genetically at risk for type 1 diabetes.Whole-genome expression analyses of type 2 diabetes in human skin reveal altered immune function and burden of infection.Polymorphisms in the innate immune IFIH1 gene, frequency of enterovirus in monthly fecal samples during infancy, and islet autoimmunity Genome-virome interactions: examining the role of common viral infections in complex disease.Interleukin-2 inhibits FMS-like tyrosine kinase 3 receptor ligand (flt3L)-dependent development and function of conventional and plasmacytoid dendritic cells dsRNA sensors and plasmacytoid dendritic cells in host defense and autoimmunity.Ifih1 gene dose effect reveals MDA5-mediated chronic type I IFN gene signature, viral resistance, and accelerated autoimmunity.The genetic basis of graves' disease.Autoimmune disease risk variant of IFIH1 is associated with increased sensitivity to IFN-α and serologic autoimmunity in lupus patients.Enterovirus RNA in peripheral blood may be associated with the variants of rs1990760, a common type 1 diabetes associated polymorphism in IFIH1.A novel dermato-pulmonary syndrome associated with MDA-5 antibodies: report of 2 cases and review of the literature.Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes The RIG-I-like helicase receptor MDA5 (IFIH1) is involved in the host defense against Candida infections Genetics of the type I interferon pathway in systemic lupus erythematosus.The pancreatic β cell and type 1 diabetes: innocent bystander or active participant?Viral infections in type 1 diabetes mellitus--why the β cells?Immunology in the clinic review series; focus on type 1 diabetes and viruses: the innate immune response to enteroviruses and its possible role in regulating type 1 diabetes.Association of IFIH1 rs1990760 polymorphism with susceptibility to autoimmune diseases: a meta-analysis.Genetic insights into common pathways and complex relationships among immune-mediated diseases.Candidate genes expressed in human islets and their role in the pathogenesis of type 1 diabetes.Candidate genes for type 1 diabetes modulate pancreatic islet inflammation and β-cell apoptosis.Effects of type 1 diabetes-associated IFIH1 polymorphisms on MDA5 function and expression.The A946T variant of the RNA sensor IFIH1 mediates an interferon program that limits viral infection but increases the risk for autoimmunity.Functional characterization of the Thr946Ala SNP at the type 1 diabetes IFIH1 locus.Type 1 Diabetes Candidate Genes Linked to Pancreatic Islet Cell Inflammation and Beta-Cell Apoptosis.AIRE-Deficient Patients Harbor Unique High-Affinity Disease-Ameliorating Autoantibodies Innate Viral Receptor Signaling Determines Type 1 Diabetes Onset.Interferon and interferon-inducible gene activation in patients with type 1 diabetes.Coxsackievirus B1 reveals strain specific differences in plasmacytoid dendritic cell mediated immunogenicity.Redox-Sensitive Innate Immune Pathways During Macrophage Activation in Type 1 Diabetes.Rare variants in TMEM132D in a case-control sample for panic disorder.Loss-of-function mutation in Mirta22/Emc10 rescues specific schizophrenia-related phenotypes in a mouse model of the 22q11.2 deletion.On type 1 diabetes mellitus pathogenesis.

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Reduced expression of IFIH1 is protective for type 1 diabetes.

http://www.wikidata.org/entity/Q34115336

description

2010 nî lūn-bûn

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2010 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Reduced expression of IFIH1 is protective for type 1 diabetes.

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Reduced expression of IFIH1 is protective for type 1 diabetes.

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Reduced expression of IFIH1 is protective for type 1 diabetes.

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type

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Reduced expression of IFIH1 is protective for type 1 diabetes.

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Reduced expression of IFIH1 is protective for type 1 diabetes.

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Reduced expression of IFIH1 is protective for type 1 diabetes.

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prefLabel

Reduced expression of IFIH1 is protective for type 1 diabetes.

@ast

Reduced expression of IFIH1 is protective for type 1 diabetes.

@en

Reduced expression of IFIH1 is protective for type 1 diabetes.

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Reduced expression of IFIH1 is protective for type 1 diabetes.

@en

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Karen L Angus

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Kate Downes

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Marcin Pekalski

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Sarah Nutland

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P2860

The interferon induced with helicase domain 1 A946T polymorphism is not associated with rheumatoid arthritis

Mapping and quantifying mammalian transcriptomes by RNA-Seq

mda-5: An interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties

Differential viral induction of distinct interferon-alpha genes by positive feedback through interferon regulatory factor-7

Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes

Melanoma Differentiation-Associated Gene 5 (MDA5) Is Involved in the Innate Immune Response to Paramyxoviridae Infection In Vivo

Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3

Involvement of the IRF family transcription factor IRF-3 in virus-induced activation of the IFN-beta gene

Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity

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scholarly article

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10.1371/JOURNAL.PONE.0012646

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46282099

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20844740

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type-1 diabetes

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2936573

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