Cholesterol oxidation in the retina: implications of 7KCh formation in chronic inflammation and age-related macular degeneration - Wikidata - awgldk - TriplyDB

Cholesterol oxidation in the retina: implications of 7KCh formation in chronic inflammation and age-related macular degeneration

Cholesterol oxidation in the retina: implications of 7KCh formation in chronic inflammation and age-related macular degeneration

http://www.wikidata.org/entity/Q34116399

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Cholesterol-enriched diet causes age-related macular degeneration-like pathology in rabbit retina Lipid biomarkers of oxidative stress in a genetic mouse model of Smith-Lemli-Opitz syndrome 7-Dehydrocholesterol-derived oxysterols and retinal degeneration in a rat model of Smith-Lemli-Opitz syndrome AMD and the alternative complement pathway: genetics and functional implications Regulation of signaling events involved in the pathophysiology of neovascular AMD The unfolded protein response in retinal vascular diseases: implications and therapeutic potential beyond protein folding Oxysterols in the pathogenesis of major chronic diseases Macular xanthophylls, lipoprotein-related genes, and age-related macular degeneration Abnormal vascularization in mouse retina with dysregulated retinal cholesterol homeostasis.Ion-current-based proteomic profiling of the retina in a rat model of Smith-Lemli-Opitz syndrome.Oxysterols and their cellular effectors.Cholesterol in the retina: the best is yet to come.Differential effects of the estrogen receptor agonist estradiol on toxicity induced by enzymatically-derived or autoxidation-derived oxysterols in human ARPE-19 cells.Why AMD is a disease of ageing and not of development: mechanisms and insights.7-Ketocholesterol-induced inflammation signals mostly through the TLR4 receptor both in vitro and in vivo.Sterculic acid antagonizes 7-ketocholesterol-mediated inflammation and inhibits choroidal neovascularization.The ins and outs of cholesterol in the vertebrate retina.Age-related macular degeneration: genetics and biology coming together.7-Ketocholesterol induces inflammation and angiogenesis in vivo: a novel rat model.7-ketocholesterol accumulates in ocular tissues as a consequence of aging and is present in high levels in drusen.Mechanisms of oxysterol-induced carcinogenesis.Conversion of 7-ketocholesterol to oxysterol metabolites by recombinant CYP27A1 and retinal pigment epithelial cells.Inflammasomes Induced by 7-Ketocholesterol and Other Stimuli in RPE and in Bone Marrow-Derived Cells Differ Markedly in Their Production of IL-1β and IL-18.7-Ketocholesterol increases retinal microglial migration, activation, and angiogenicity: a potential pathogenic mechanism underlying age-related macular degeneration Extra-hepatic metabolism of 7-ketocholesterol occurs by esterification to fatty acids via cPLA2α and SOAT1 followed by selective efflux to HDL Novel oxysterols observed in tissues and fluids of AY9944-treated rats: a model for Smith-Lemli-Opitz syndrome.Free radical oxidation of cholesterol and its precursors: Implications in cholesterol biosynthesis disorders.Structural characterization of human cholesterol 7α-hydroxylase CETP/LPL/LIPC gene polymorphisms and susceptibility to age-related macular degeneration.Complement dysregulation in AMD: RPE-Bruch's membrane-choroid Assays of plasma dehydrocholesteryl esters and oxysterols from Smith-Lemli-Opitz syndrome patients Posttranslational modification by an isolevuglandin diminishes activity of the mitochondrial cytochrome P450 27A1 Aging is not a disease: distinguishing age-related macular degeneration from aging.7-ketocholesterol induces apoptosis of MC3T3-E1 cells associated with reactive oxygen species generation, endoplasmic reticulum stress and caspase-3/7 dependent pathway 7-Ketocholesterol induces ATM/ATR, Chk1/Chk2, PI3K/Akt signalings, cytotoxicity and IL-8 production in endothelial cells.Mechanism of inflammation in age-related macular degeneration: an up-to-date on genetic landmarks.Consumption of Red/Processed Meat and Colorectal Carcinoma: Possible Mechanisms Underlying the Significant Association.Plasma lipoprotein subfraction concentrations are associated with lipid metabolism and age-related macular degeneration.Inhibition of endothelial- and neuronal-type, but not inducible-type, nitric oxide synthase by the oxidized cholesterol metabolite secosterol aldehyde: Implications for vascular and neurodegenerative diseases.Differential cytotoxic effects of 7-dehydrocholesterol-derived oxysterols on cultured retina-derived cells: Dependence on sterol structure, cell type, and density.

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P2860

Cholesterol oxidation in the retina: implications of 7KCh formation in chronic inflammation and age-related macular degeneration

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2010 nî lūn-bûn

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2010 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2010 թվականի հունիսին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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Cholesterol oxidation in the r ...... e-related macular degeneration

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Cholesterol oxidation in the r ...... e-related macular degeneration

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Ignacio M Larrayoz

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Ignacio R Rodríguez

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P2860

cDNA cloning of mouse and human cholesterol 25-hydroxylases, polytopic membrane proteins that synthesize a potent oxysterol regulator of lipid metabolism

Expression cloning of an oxysterol 7alpha-hydroxylase selective for 24-hydroxycholesterol

Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta

NAD(P)H oxidase Nox-4 mediates 7-ketocholesterol-induced endoplasmic reticulum stress and apoptosis in human aortic smooth muscle cells

Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration

Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC)

Cholesterol 24-hydroxylase: an enzyme of cholesterol turnover in the brain

Oxysterol 7alpha-hydroxylase (CYP39A1) in the ciliary nonpigmented epithelium of bovine eye

Auto-oxidized cholesterol sulfates are antagonistic ligands of liver X receptors: implications for the development and treatment of atherosclerosis

Molecular and biochemical characterization of a novel oxysterol-binding protein (OSBP2) highly expressed in retina

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