Functional Inhibitors of Acid Sphingomyelinase (FIASMAs): a novel pharmacological group of drugs with broad clinical applications.
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Identification of novel functional inhibitors of acid sphingomyelinaseInhibition of acid sphingomyelinase by tricyclic antidepressants and analogonsA central role for the acid sphingomyelinase/ceramide system in neurogenesis and major depressionExcess sphingomyelin disturbs ATG9A trafficking and autophagosome closure.A screen of approved drugs and molecular probes identifies therapeutics with anti-Ebola virus activity.Amitriptyline Usage Exacerbates the Immune Suppression Following Burn InjuryHyperresponsiveness of mice deficient in plasma-secreted sphingomyelinase reveals its pivotal role in early phase of host responseIdentification of drugs inducing phospholipidosis by novel in vitro dataCholesterol-mediated activation of acid sphingomyelinase disrupts autophagy in the retinal pigment epitheliumIncreased Multinucleated Megakaryocytes as an Isolated Finding in Bone Marrow: A Rare Finding and Its Clinical Significance.Organelle-specific activity-based protein profiling in living cells.Adjustment of Dysregulated Ceramide Metabolism in a Murine Model of Sepsis-Induced Cardiac Dysfunction.β1-Integrin Accumulates in Cystic Fibrosis Luminal Airway Epithelial Membranes and Decreases Sphingosine, Promoting Bacterial InfectionsHost-directed antimicrobial drugs with broad-spectrum efficacy against intracellular bacterial pathogens.A high-throughput sphingomyelinase assay using natural substrate.Stimulation of suicidal erythrocyte death by fumagillin.Inhibition of acidic sphingomyelinase reduces established hepatic fibrosis in miceAcid sphingomyelinase serum activity predicts mortality in intensive care unit patients after systemic inflammation: a prospective cohort studyCharacterization of acid sphingomyelinase activity in human cerebrospinal fluidLipid raft redox signaling: molecular mechanisms in health and disease.Modulation of Insulin Sensitivity of Hepatocytes by the Pharmacological Downregulation of Phospholipase D.Triangulated mal-signaling in Alzheimer's disease: roles of neurotoxic ceramides, ER stress, and insulin resistance reviewedRepurposing Cationic Amphiphilic Antihistamines for Cancer TreatmentRole of Acid Sphingomyelinase in the Regulation of Social Behavior and Memory.Selective dynamic concentration of peptides at poles of cation-selective nanoporous granulesCeramides: a potential therapeutic target in pulmonary emphysema.Membrane signaling induced by high doses of ionizing radiation in the endothelial compartment. Relevance in radiation toxicity.Selective inhibition of Ebola entry with selective estrogen receptor modulators by disrupting the endolysosomal calcium.Paradoxical antidepressant effects of alcohol are related to acid sphingomyelinase and its control of sphingolipid homeostasis.Drug targeting of sphingolipid metabolism: sphingomyelinases and ceramidases.Ceramide formation as a target in beta-cell survival and function.Drug-drug interactions involving lysosomes: mechanisms and potential clinical implications.Cancer-associated lysosomal changes: friends or foes?Role of sphingomyelinases in neurological disorders.Ceramide and Its Related Neurochemical Networks as Targets for Some Brain Disorder Therapies.Ceramide formation mediated by acid sphingomyelinase facilitates endosomal escape of caliciviruses.Direct inhibition of retinoic acid catabolism by fluoxetine.Antiviral activity of cationic amphiphilic drugs.Gilenya (FTY720) inhibits acid sphingomyelinase by a mechanism similar to tricyclic antidepressants.Acid Sphingomyelinase Inhibition Prevents Hemolysis During Erythrocyte Storage.
P2860
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P2860
Functional Inhibitors of Acid Sphingomyelinase (FIASMAs): a novel pharmacological group of drugs with broad clinical applications.
description
2010 nî lūn-bûn
@nan
2010 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
name
Functional Inhibitors of Acid ...... h broad clinical applications.
@ast
Functional Inhibitors of Acid ...... h broad clinical applications.
@en
Functional Inhibitors of Acid Sphingomyelinase
@nl
type
label
Functional Inhibitors of Acid ...... h broad clinical applications.
@ast
Functional Inhibitors of Acid ...... h broad clinical applications.
@en
Functional Inhibitors of Acid Sphingomyelinase
@nl
prefLabel
Functional Inhibitors of Acid ...... h broad clinical applications.
@ast
Functional Inhibitors of Acid ...... h broad clinical applications.
@en
Functional Inhibitors of Acid Sphingomyelinase
@nl
P2093
P50
P356
P1476
Functional Inhibitors of Acid ...... h broad clinical applications.
@en
P2093
Cosima Rhein
Markus Muehlbacher
Martin Reichel
Philipp Tripal
P356
10.1159/000315101
P577
2010-05-18T00:00:00Z